A5026680750- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Cardiovascular and Diving-Related Complications
- Coronary Interventions and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiac tumors and thrombi
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Paraoxonase enzyme and polymorphisms
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Trauma Management and Diagnosis
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Heart Failure Treatment and Management
Okayama University
2011-2018
Okayama University Hospital
2012-2018
Sakurabashi Watanabe Hospital
2017-2018
Seoul National University Hospital
2013
Azienda Ospedaliero Universitaria San Giovanni Battista
2013
University of Turin
2013
Türkiye Yüksek İhtisas Hastanesi
2013
Osaka Ekisaikai Hospital
2008-2011
Osaka City University
2005-2010
Cleveland Clinic
2010
Alpha glucosidase inhibitor (GI) attenuates postprandial hyperglycemia (PPH) and reduces the risk of cardiovascular events in patients with impaired glucose tolerance or type 2 diabetes. Dipeptidyl peptidase 4 (DPP-4) inhibitors also attenuate PPH. PPH is one factors leading to endothelial dysfunction which an early event pathogenesis atherosclerosis. Furthermore, DPP-4 protect function through a GLP-1-dependent mechanism. However, impact these two types drugs on diabetes has not been fully...
Postprandial hyperlipidemia impairs endothelial function and participates in the development of atherosclerosis. We investigated postprandial effects a dipeptidyl peptidase IV inhibitor, alogliptin, on dysfunction lipid profile.A randomized cross-over trial design 10 healthy volunteers (8 males 2 females, 35 ± years) was performed. The before after 1-week treatment 25 mg/day alogliptin were assessed with brachial artery flow-mediated dilation (FMD) changing levels lipids, apolipoprotein B48...
Heart failure with left ventricular (LV) hypertrophy is often associated insulin resistance and inflammation. Recent studies have shown that dipeptidyl peptidase 4 (DPP4) inhibitors improve glucose metabolism inflammatory status. We therefore evaluated whether vildagliptin, a DPP4 inhibitor, prevents LV improves diastolic function in isoproterenol-treated rats. Male Wistar rats received vehicle (n = 20), subcutaneous isoproterenol (2.4 mg/kg/day, n 20) (ISO), mg/kg/day + oral vildagliptin...
The recently introduced pocket-sized portable transthoracic echocardiography (pTTE) is accurate for measurement of cardiac chamber size and function as well assessment valvular regurgitation. This study aimed to compare the diagnostic accuracy pTTE with standard TTE (sTTE) assess its cost-effectiveness.The use pTTE, an initial screening tool, may be feasible, cost-effective in strategy abnormalities.The subjects were 200 patients scheduled sTTE electrocardiogram (ECG). Each patient underwent...
Left ventricular (LV) diastolic dysfunction is frequently observed in patients with type 2 diabetes. Dipeptidyl peptidase-4 inhibitor (DPP-4i) attenuates postprandial hyperglycemia (PPH) and may have cardio-protective effects. It remains unclear whether DPP-4i improves LV function diabetes, and, if so, it attributable to the attenuation of PPH or a direct cardiac effect DPP-4i. We compared effects DPP-4i, sitagliptin, alpha-glucosidase inhibitor, voglibose, on conducted prospective,...
Although many studies on Brugada syndrome have been done, with reports of genetic findings and clinical features, little evidence exists to support the role this in sudden cardiac death a juvenile population. We sought determine prevalence course children exhibiting Brugada-type ECG community-based population.Our study population comprised 21,944 subjects (11,282 boys 10,662 girls) who underwent during their first-year elementary school health examinations between 1992 2001 Izumi City,...
Postprandial elevation of triglyceride-rich lipoproteins impairs endothelial function, which can initiate atherosclerosis. We investigated the effects bezafibrate on postprandial dysfunction and lipid profiles in patients with metabolic syndrome. Ten syndrome were treated 400 mg/day or untreated for 4 weeks a randomized crossover study. Brachial artery flow-mediated dilation (FMD) assessed during fasting after consumption standardized snack. Serum triglyceride cholesterol contents...
Background:Patients with pulmonary arterial hypertension (PAH) are currently treated combination therapy of PAH-targeted drugs. Reverse right ventricular (RV) remodeling after lung transplantation (LTx) in patients end-stage PAH despite drugs has not been fully elucidated.
We investigated the acute effects of implantable cardioverter-defibrillator shock on myocardium, cardiac function, and hemodynamics in relation to left ventricular systolic function.We studied 50 patients who underwent implantation defibrillation threshold (DFT) testing: 25 with ejection fraction (LVEF) ≥ 45% LVEF <45%. measured biomarkers (creatine kinase, creatine kinase-MB, myoglobin, troponin T I, N-terminal probrain natriuretic peptide). Left relaxation was assessed by global...
Aneurysmal circumflex coronary artery (Cx) with fistulous connection to the sinus is a rare clinical entity that usually remains asymptomatic until later in life, so ideal therapeutic strategy poorly defined. The timing of surgical treatment for patients big issue, and whether leave or exclude diffuse aneurysm addition ligation fistula controversial, considering native myocardial circulation. Complete repair, including exclusion diffusely aneurysmal Cx revascularization graftable branch area...
Background: Noninvasive and accurate assessment of mitral valve anatomy has become integral in the presurgical evaluation patients with prolapse (MVP). Recently developed real time three‐dimensional (RT3D) ultrasound allows online acquisition, rendering, can provide information on cardiac structures. We sought to evaluate feasibility RT3D for MVP segments when compared transesophageal echocardiography (TEE) intraoperative findings. Methods: examined 42 using RT3D, two‐dimensional (2D)...
<h3>Background:</h3> Arachidonic acid (ARA) and docosahexaenoic (DHA) are important components of phospholipids cell membranes. There has, however, been no clinical report on the direct effects ARA DHA coronary circulation. <h3>Objective:</h3> To evaluate circulation using measurement flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE). <h3>Methods:</h3> A double-blind, placebo-matched study 28 Japanese elderly individuals (19 men, mean age 65 years) conducted to...
Endothelial function is a prognostic predictor in patients undergoing percutaneous coronary intervention (PCI). However, an era with widespread use of drug-eluting stents, the clinical relevance endothelial dysfunction on restenosis PCI has not been fully evaluated. This study included 80 stable angina pectoris. Flow-mediated dilation (FMD) brachial artery was examined 1 week after PCI. Patients were retrospectively followed-up for average 21 months The primary endpoints cardiac death,...