A5048434031- Veterinary Oncology Research
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Veterinary Medicine and Surgery
- Inflammatory mediators and NSAID effects
- Amino Acid Enzymes and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Human-Animal Interaction Studies
- Estrogen and related hormone effects
- Nanoplatforms for cancer theranostics
- Polyamine Metabolism and Applications
- Monoclonal and Polyclonal Antibodies Research
- Eicosanoids and Hypertension Pharmacology
- Urological Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Medical Imaging Techniques and Applications
- Axon Guidance and Neuronal Signaling
- Oral and Maxillofacial Pathology
Purdue University West Lafayette
2016-2025
Purdue University Institute for Cancer Research
2004-2025
Institute for Research in Immunology and Cancer
2024-2025
Université de Montréal
2024-2025
Center for Cancer Research
2013-2023
National Human Genome Research Institute
2015-2023
National Institutes of Health
2015-2018
National Cancer Institute
2018
Royal North Shore Hospital
2017
NetApp (United States)
2013
Thirty‐four dogs with histopathologically confirmed, measurable, nonresectable transitional cell carcinoma of the urinary bladder were treated piroxicam (0.3 mg/kg PO sid) and evaluated for tumor response drug toxicity. Dogs at Purdue University Veterinary Teaching Hospital by means physical examination, thoracic abdominal radiography, cystography, complete blood count, serum biochemistry profile, urinalysis. In selected cases, prostaglandin E 2 (PGE ) concentrations in plasma supernatants...
Transitional cell carcinoma (TCC) of the urinary bladder, most common malignancy tract in dogs, is challenging to both diagnose and treat effectively. The prevalence this disease may be increasing. etiology canine TCC likely multifactorial. Epidemiological studies dog have revealed a number risk factors, including breed female gender, as well environmental such insecticide exposure. This tumor difficult remove surgically responds poorly chemotherapy. efficacy radiotherapy other treatment...
Forty-eight dogs with histologically confirmed appendicular osteosarcoma (OSA) entered a prospective clinical trial evaluating treatment amputation and up to 4 doses of carboplatin given every 21 days. The median disease-free interval (DFI) was 257 days, 31.2% the at 1 year. survival time 321 35.4% alive Dogs proximal humeral OSA had shorter DFI (P = .016) .037) times than other locations. lower body weights ( < 40 kg) longer .0056) .007) larger dogs. Survival for that received were...
Abstract Targeted cancer therapies offer great clinical promise, but treatment resistance is common, and basic research aimed at overcoming this challenge limited by reduced genomic biologic complexity in artificially induced rodent tumors compared with their human counterparts. Animal models that more faithfully recapitulate genotype-specific pathology could improve the predictive value of these investigations. Here, a newly identified animal model for oncogenic BRAF-driven cancers...
To evaluate expression of cyclooxygenase (COX)-1 and COX-2 in the urinary bladder epithelium clinically normal dogs transitional cell carcinoma cells dogs.21 with 8 bladders.COX-1 were evaluated by use isoform-specific antibodies standard immunohistochemical methods.COX-1, but not COX-2, was constitutively expressed epithelium; however, neoplastic primary tumors metastatic lesions all 21 new proliferating blood vessels 3 dogs. Also, COX-1 cells.Lack its substantial suggest that this isoform...
A retrospective study of 43 dogs with anal sac adenocarcinoma (ASAC) was performed to characterize the clinical presentation and response treatment. Clinical signs at varied considerably, related either sublumbar nodal metastasis (tenesmus or constipation) hypercalcemia (polyuria‐polydipsia anorexia) being most frequent findings. At time presentation, 23 (53%) had 34 (79%) metastases, regional lymph nodes (31 dogs, 72%) common site metastasis. variety chemotherapeutic agents were...
Abstract Objective —To determine whether exposure to lawn or garden chemicals was associated with an increased risk of transitional cell carcinoma (TCC) the urinary bladder in Scottish Terriers. Design —Case-control study. Animals —83 Terriers TCC (cases) and 83 other health-related conditions (controls). Procedure —Owners study dogs completed a written questionnaire pertaining during year prior diagnosis for case comparable period control dogs. Results —The significantly among exposed lawns...
Abstract Objective —To evaluate the use of piroxicam for treatment oral squamous cell carcinoma in dogs. Design —Prospective case series. Animals —17 dogs with measurable carcinoma. Procedure —Dogs were treated at a dosage 0.3 mg/kg (0.14 mg/lb) body weight, PO, every 24 hours until progressive disease or unacceptable signs toxicosis developed dog died. Results —One had complete remission (maxillary tumor), and 2 partial remissions (lingual tumor tonsillar tumor). An additional 5 stable...
Desorption electrospray ionization mass spectrometry (DESI-MS) was used in an imaging mode to interrogate the lipid profiles of thin tissue sections canine spontaneous invasive transitional cell carcinoma urinary bladder (a model human cancer) as well adjacent normal from four different dogs. The glycerophospholipids and sphingolipids that appear intense signals both negative ion positive modes were identified by tandem product scans using collision-induced dissociation. Differences relative...
Abstract Objective —To determine the maximum tolerated dose (MTD) of cisplatin administered with piroxicam, antitumor activity and toxicity combined piroxicam in dogs oral malignant melanoma (OMM) squamous cell carcinoma (SCC), effects on pharmacokinetics tumors. Design —Prospective nonrandomized clinical trial. Animals —25 dogs. Procedure —Dogs were treated a combination (escalating 6 hours diuresis saline [0.9% NaCl] solution) (0.3 mg/kg [0.14 mg/lb], PO, q 24 h). The initial (50 mg/m2)...
The current study examines the trajectories of student perceived gains as a result time spent in an undergraduate research experience (URE). Data for come from survey administered at three points over 1-yr period: before participation program, end Summer segment research, and year. Repeated-measures analysis variance was used to examine effect on skills, confidence, understanding processes. results suggest that students experienced different gains/benefits developmentally stages their UREs....
The purpose of our study was to determine if specific host factors, such as age at diagnosis, obesity, and hormone status, influence the prognosis canine mammary gland carcinomas confirm previously reported risk factors (ie, histologic subtype, tumor size, World Health Organization [WHO] stage) were important in a large series affected dogs. Ninety-nine female dogs with carcinomas, no previous therapy, an excisional biopsy, known cause death studied. No significant association survival noted...
The purpose of this study was to determine if the presence histopathologically tumor-free versus nontumor-free margins prognostic for relapse or tumor-related death in dogs following surgical excision single multiple cutaneous mast cell tumors confined skin without evidence metastasis lymph nodes other noncutaneous sites. Differences frequency between two groups were not significant. Failure achieve histopathological frequently did lead local relapse. All deaths occurred lack statistical...