A5075746596- Veterinary Oncology Research
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Infectious Diseases and Mycology
- Microbial infections and disease research
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Hedgehog Signaling Pathway Studies
- Digital Holography and Microscopy
- Optical Coherence Tomography Applications
- Cell Adhesion Molecules Research
- Veterinary Medicine and Surgery
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- RNA Research and Splicing
- Advanced Fluorescence Microscopy Techniques
- Mast cells and histamine
- Molecular Biology Techniques and Applications
- Cell Image Analysis Techniques
- Lymphoma Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Hematopoietic Stem Cell Transplantation
- Cancer Diagnosis and Treatment
Purdue University West Lafayette
2016-2025
Purdue University Institute for Cancer Research
2023
Center for Cancer Research
2014-2021
Iowa State University
2020
Carolina Veterinary Specialists
2020
Indiana University School of Medicine
2018
NetApp (United States)
2013
Japan Small Animal Medical Center
2013
University of Georgia
2009
Background Transitional cell carcinoma ( TCC ) of the urinary bladder dogs can be a difficult cancer to treat, and effective therapies are limited. Vinblastine has been used in humans with potent anti‐proliferative effects against canine cells vitro. Objectives To determine antitumor activity toxicoses vinblastine . Animals selected were 28 privately owned that presented Purdue University Veterinary Teaching Hospital PUVTH measurable, histologically confirmed Methods Prospective clinical...
The purpose of this study was to assess the toxicoses and antitumor activity metronomic chlorambucil at a dosage 4 mg m(-2) daily in dogs with naturally occurring cancer. Thirty-six were enrolled study. protocol well tolerated no grade 3 or noted. Complete remission achieved, lasted over 35 weeks three (mast cell tumour, soft tissue sarcoma thyroid carcinoma). Partial noted 1 dog histiocytic (39 duration) for an overall rate 11% (4 36). Stable disease 17 (47%) various other cancers. median...
To determine the antitumor effects and toxicoses of metronomic oral administration a low dose chlorambucil in dogs with transitional cell carcinoma (TCC). Prospective clinical trial. 31 client-owned TCC for which prior treatments had failed or owners declined other treatments. Procedures-Chlorambucil (4 mg/m2, PO, q 24 h) was administered to dogs. Before at scheduled times during treatment, evaluations included physical examination, CBC, serum biochemical analyses, urinalysis, thoracic...
To determine uroplakin III expression, potential etiologic factors, biological behavior, and treatment response of transitional cell carcinoma (TCC) in the abdominal wall (ABWTCC) dogs.Retrospective case series.24 dogs with TCC urinary tract that also had histopathologic confirmation ABWTCC.Medical records, histologic slides, radiographs, ultrasonographic images ABWTCC between July 1, 1985, December 31, 2010, were reviewed. In available tissue specimens, immunohistochemistry was used to...
Numerous factors are known to affect the prognosis of dogs with chemotherapy‐treated lymphomas. However, prognostic for specific subtypes lymphoma less clearly defined. The objective this study was identify receiving CHOP‐based chemotherapy primary nodal diffuse large B‐cell (DLBCL). Medical records treated DLBCL at Purdue Veterinary Teaching Hospital (PUVTH) from 2006 2016 were reviewed. Factors potentially related analysed using multivariable statistical methods. Ninety‐eight included in...
Abstract Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition is biologically achievable with sirolimus, and might slow the outgrowth distant metastases. In this study, pet dogs appendicular osteosarcoma were leveraged high-value biologic models for pediatric osteosarcoma, to assess inhibition therapeutic strategy attenuating disease progression. Patients Methods: A total 324 diagnosed...
Biodynamic digital holography was used to obtain phenotypic profiles of canine non-Hodgkin B-cell lymphoma biopsies treated with standard-of-care chemotherapy. signatures from the living 3D tissues were extracted using fluctuation spectroscopy intracellular Doppler light scattering in response molecular mechanisms action therapeutic drugs that modify a range internal cellular motions. The treat both humans and dogs is combination CHOP therapy consists doxorubicin, prednisolone,...
Abstract Objective —To assess the diagnostic utility of transurethral cystoscopic biopsy in dogs with histologically confirmed transitional cell carcinoma (TCC) urinary bladder and urethra. Design —Retrospective case series. Animals —92 TCC. Procedures —Information on sex, breed, neuter status, body weight, tumor location, method, number procedures, experience level clinician performing biopsy, quality sample was obtained from medical records. The association variables likelihood achieving a...
Background Molecularly-guided trials (i.e. PMed) now seek to aid clinical decision-making by matching cancer targets with therapeutic options. Progress has been hampered the lack of models that account for individual-to-individual heterogeneity within and across types. Naturally occurring cancers in pet animals are heterogeneous thus provide an opportunity answer questions about these PMed strategies optimize translation human patients. In order realize this opportunity, it is necessary...
Intracellular dynamics in living tissue are dominated by active transport driven bioenergetic processes far from thermal equilibrium. constituents typically execute persistent walks. In the limit of long mean-free paths, walks ballistic, exhibiting a "Doppler edge" light scattering fluctuation spectra. At shorter lengths, fluctuations described lifetime-broadened Doppler Dynamic diffusive or cross-over regime is derived analytically, including derivation autocorrelation functions through...
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is a common and aggressive form of in dogs, closely resembling human DLBCL its clinical behavior molecular features. While CHOP chemotherapy the standard treatment, many dogs experience poor responses or early relapse, underscoring need for more comprehensive understanding disease’s underpinnings. This study aimed to investigate gene expression profiles canine identify potential biomarkers therapeutic targets. Materials Methods:...
Background Canine hemangiosarcoma is a common and aggressive vascular malignancy predominantly affecting dogs over six years of age. Despite surgical resection followed by adjuvant chemotherapy, median survival remains around 4-6 months. Propranolol, beta-adrenergic receptor (b-AR) antagonist, has shown efficacy in human angiosarcoma, tumor with similar clinical morphological characteristics, when combined chemotherapy. Methods To determine if propranolol could be repurposed as an effective...
Osteosarcoma is the most common primary malignant bone tumor and predominantly affects children, adolescents, young adults. It third cause of cancer-related deaths among 9-24-year-olds. Despite aggressive chemotherapeutic surgical therapies, survival rate only 25% for patients with detectable lung metastases at diagnosis 70% in that present without metastases. The poor prognosis due to growth irrespective whether they are initially large enough detect clinically. therefore necessary develop...
Exploring lipid information characteristic of non-Hodgkin's lymphoma using DESI – mass spectrometry.
The Syk protein tyrosine kinase, a well-characterized regulator of immune cell function, plays an increasingly recognized role in tumorigenesis as promoter survival both hematological and nonhematological malignancies. We show here that the expression MCF7 or MDA-MB-231 breast cancer cells DG75 B-lymphoma protects from apoptosis induced by oxidative genotoxic stress stabilizing mRNA for Bcl-x(L), antiapoptotic protein. binds robustly to nucleolin phosphorylates it on tyrosine, enhancing its...
Forty-one dogs with resistant lymphoma were treated a modified MOPP (mechlorethamine, vincristine, procarbazine and prednisone) protocol (MPP [mechlorethamine, prednisone] administered on 21-day cycle, shortened from the 28-day cycle). The overall response rate to MPP was 34% for median of 56 days (95% confidence interval 30-238). Seventeen percent had complete duration 238 days, 17% partial 32% stable disease 24 days. Histological grade or cell morphology cytology associated response....
Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen 17), gastrointestinal (GI) tract 15) using immunohistochemistry. Twenty-eight percent cutaneous MCTs, 18% splenic 53% GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity detected 3 1 MCT. Sixty-nine 35% 33% were positive for KIT. these biogenic amines less common than expected. Results this study suggest heterogeneity based on anatomic...
Uterus masculinus (persistent Mullerian duct) is a vestigial embryological remnant of the paramesonephric duct system in males and has been associated with clinical signs such as dysuria, incontinence, tenesmus urethral obstruction dogs. The radiological appearance cystic uterus dogs described previously aid retrograde positive or negative contrast cystography. purpose this retrospective study was to describe ultrasonographic features confirmed presumed group disease. Ultrasonographic...
Abstract Piroxicam has antitumour effects in dogs with cancer, although side may limit its use. The purpose of this study was to retrospectively identify factors predisposing cancer‐bearing adverse events ( AEs ) following piroxicam therapy. Medical records presented the Purdue Veterinary Teaching Hospital between 2005 and 2015 were reviewed, 137 met criteria for inclusion. Toxic these graded according an established system. Multivariate logistic regression used estimate extent which certain...
Early detection and intervention research is expected to improve the outcomes for patients with high grade muscle invasive urothelial carcinoma (InvUC). With limited in suitable high-risk study cohorts, relevant animal model critical. Experimental models often fail adequately represent human cancer. The purpose of this was determine suitability dogs breed-associated risk naturally-occurring InvUC serve as early research. feasibility screening intervention, similarities differences between...
OBJECTIVE To determine the effect of prednisone omission from a multidrug chemotherapy protocol on outcome in dogs with peripheral nodal lymphomas. DESIGN Single-center, nonblinded, parallel-group, randomized, controlled trial. ANIMALS 40 client-owned histopathologically confirmed diagnosis lymphoma and an expected survival time > 4 weeks treatment. PROCEDURES Treatment consisted combination L-asparaginase, cyclophosphamide, doxorubicin, vincristine, (L-CHOP) or identical except for (L-CHO)....
Radiation therapy is a primary treatment modality for many forms of cancer. Normally, the highest tolerable dose ionizing radiation used to treat tumors, but limitations imposed by normal tissue complications present challenges local tumor control. In light this, class compounds called radio-sensitizers have been developed enhance effectiveness radiation. Many these are small molecule drugs found interact favorably with therapy, recent advances made using nanoparticles as radio-sensitizers....
Abstract The study hypothesis is that higher doses of metronomic (low‐dose) chlorambucil will improve outcome without significantly worsening adverse events ( AE ). Retrospectively, 88 dogs were screened to assess for tolerability and response utilizing retrospective prospective data sets, comparing oral daily 4, 6 8 mg m 2 . There 78 70 in the efficacy portions, respectively. severity gastrointestinal GI ) was worse, time development shorter at than 4 (both P < 0.001). Chlorambucil...