A5020674435- Veterinary Oncology Research
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Microbial infections and disease research
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- Vascular Tumors and Angiosarcomas
- Hedgehog Signaling Pathway Studies
- Peptidase Inhibition and Analysis
- Oral and Maxillofacial Pathology
- Telomeres, Telomerase, and Senescence
- TGF-β signaling in diseases
- Head and Neck Surgical Oncology
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
- Human-Animal Interaction Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Veterinary Medicine and Surgery
- Melanoma and MAPK Pathways
- Cardiac tumors and thrombi
California Animal Hospital
2011-2020
Virginia–Maryland College of Veterinary Medicine
2018
Universidade de São Paulo
2018
New Mexico VA Health Care System
2015-2016
Michigan State University
2005-2014
Michigan United
2014
Colorado State University
2007-2013
Van Andel Institute
2013
IVDiagnostics (United States)
2013
University of Michigan
2013
Feline immunodeficiency virus (FIV) is a lentivirus associated with AIDS-like illnesses in cats. As such, FIV appears to be feline analog of human (HIV). A hallmark HIV infection the large degree viral genetic diversity that can develop within an infected individual and even greater continually increasing level among isolates from different individuals. Our goal this study was determine patterns by focusing on 684-nucleotide region encompassing variable regions V3, V4, V5 env gene order...
Nineteen dogs were treated for osteosarcoma of the appendicular skeleton. Eleven by amputation and adjunctive cisplatin chemotherapy had a significantly longer (P less than 0.003) median survival time 43 weeks (range, 20 to 108 weeks) did 8 whose was 14.5 46 after alone. All 11 given evaluated signs drug toxicosis. Transient episodes vomiting recorded in 9 dogs. Additional toxic effects included gradual decreases endogenous creatinine clearance 3 thrombocytopenia 1 dog. On basis prolonged...
Summary Ninety-five mast cell tumors in 85 dogs were therapeutically irradiated. Median and mean tumor-free times for 17 62.7 months, respectively. Percentages of at 1 2 years 78.8 77%, Factors significantly affecting time clinical stage ( P <0.001) neoplasm location = 0.019). survival 19 61.2 Survival rates 76.2 73.2%, Prognostic factors that affected <0.001), grade 0.006), 0.034). Radiation therapy was an effective treatment tumor dogs.
There is an increasing need for more accurate prognostic and predictive markers in veterinary oncology because of number treatment options, the increased financial costs associated with treatment, emotional stress experienced by owners association disease its treatment. Numerous studies have evaluated potential neoplastic diseases, but there are no established guidelines or standards conduct reporting medicine. This lack standardization has made evaluation comparison difficult. Most...
A 6-year-old spayed female Golden Retriever was referred to the University of Illinois Veterinary Medical Teaching Hospital because generalized weakness and abdominal distention 3 days' duration.The dog lived outdoors on a farm did not have any history prior illness.On physical examination, dog's abdomen appeared larger than normal, an fluid wave could be palpated.Other abnormalities included otitis externa hind limb weakness.Results cardiac thoracic auscultation were normal.A CBC, serum...
Abstract Melanoma is the most common oral malignancy in dogs. This retrospective study evaluated adjuvant carboplatin chemotherapy (with or without radiation therapy) 17 dogs with malignant melanoma following surgical resection. The median dosage and number of doses administered to was 300 mg m −2 (range, 150–300 ) 4 2–11), respectively. overall progression‐free survival for all 259 days [95% confidence interval ( CI 95 ), 119–399 days]. first event local recurrence seven (41%) metastases...
Abstract Objective —To evaluate and compare the outcomes of dogs with periarticular histiocytic sarcoma (PAHS) other anatomic locations (non-PAHS) identify factors associated outcome for PAHS. Design —Retrospective cohort study. Animals —19 PAHS 31 non-PAHS. Procedures —Medical records that underwent definitive local treatment (surgery or radiation), chemotherapy, a combination these were reviewed. Patient signalment, clinical signs, staging test results, clinicopathologic data, type...
This study was designed to assess the efficacy of a matrix metalloproteinase inhibitor in prolonging posttreatment survival for dogs with appendicular osteosarcoma after treatment amputation and doxorubicin chemotherapy.Survival will be prolonged receiving BAY 12-9566.The included 303 osteosarcoma.Dogs were treated (30 mg/m2) every 2 weeks 5 treatments starting amputation. Dogs randomly allocated receive novel nonpeptidic biphenyl metalloproteinases (MMPs, 12-9566;...
To develop a quality of life (QOL) survey for use in canine cancer chemotherapy setting, validate the instrument's utility, identify key questions that facilitate client and clinician communication regarding decisions patient care, human veterinary QOL literature to comprehensive yet simple proxy instrument.Survey.29 patients.Patients were evaluated by both owners veterinarians at time initial visit clinic 3 6 weeks after initiation chemotherapy. This consisted longitudinal evaluation with...
Background Molecularly-guided trials (i.e. PMed) now seek to aid clinical decision-making by matching cancer targets with therapeutic options. Progress has been hampered the lack of models that account for individual-to-individual heterogeneity within and across types. Naturally occurring cancers in pet animals are heterogeneous thus provide an opportunity answer questions about these PMed strategies optimize translation human patients. In order realize this opportunity, it is necessary...
Eight cats with locally advanced, oral squamous cell carcinoma (SCC) were treated a combination of gemcitabine and palliative radiotherapy. Low-dose was administered twice weekly (25 mg/m2) in conjunction megavoltage radiation 6 Gray (Gy) fractions for total dose 36 Gy. Responses included two complete four partial responses, had no response to therapy. Median duration remission 42.5 days (range, 11 85 days). survival time 111.5 234 This data suggests that low-dose therapy may be tolerable...
SUMMARY Acute pancreatitis was induced in 6 cats by infusion of oleic acid into the pancreatic duct. Clinical changes included fever, tachycardia, and variable degrees abdominal pain; vomiting occurred rarely, diarrhea not noted. Serum lipase activities were significantly increased through 4th day after surgical operation, although amylase decreased during most acute phase. calcium phosphate concentrations on operation. Hematologic alterations normocytic, normochromic, responsive anemias,...
Abstract Objective —To compare results of treatment with temozolomide or dacarbazine, in combination an anthracycline, dogs relapsed refractory lymphoma. Design —Nonrandomized, controlled clinical trial. Animals —63 Procedures —Chemotherapy was administered 21-day cycles. A and anthracycline (doxorubicin dactinomycin) to 21 a dacarbazine 42 dogs. Efficacy toxicoses were assessed. Results —Thirteen the 18 (72%) treated temozolomide-anthracycline 25 35 (71%) dacarbazine-anthracycline had...
Hemangiosarcoma (HSA) is an aggressive disease that fairly common in the dog. The authors evaluated a doxorubicin, dacarbazine, and vincristine (DAV) combination protocol dogs with nonresectable stage II III HSA. Twenty-four were enrolled this prospective, phase 2 study. Doxorubicin dacarbazine administered on day 1 while was days 8 15. repeated every 21 for maximum of six cycles or until progression. Toxicity efficacy assessed by clinical laboratory evaluation questionnaires completed...
Summary Thirteen dogs with tumors were treated monthly infusions of cisplatin. Complete responses not observed. Of 8 urinary tract transitional cell carcinomas, 1 (12.5%) had a partial response 31 weeks’ duration, and 4 (50%) stable disease for 12, 30, 32, 34 weeks. Three (60%) 5 head neck squamous carcinomas 2, 10, 15 All 13 evaluated signs toxicosis. Transient episodes vomiting recorded 7 (54%), 2 (15%) mild thrombocytopenia. Although renal function gradually decreased in (15%), none the...
Background: Response and adverse reactions to combined gemcitabine (GEM) carboplatin (CARBO) therapy in dogs with carcinomas are not documented. Hypothesis: GEM CARBO safe for the treatment of carcinomas. Animals: Thirty‐seven histologically or cytologically confirmed Methods: Prospective clinical trial. Dogs were treated (2 mg/kg, 20–30‐minute infusion IV) on Days 1 8 4 hours later, (10 mg/kg Day 1. The cycle was repeated 22. Results: (29 measurable tumor) received a median 2 cycles (range...
Angiosarcoma is a rare neoplasm of endothelial origin that has limited treatment options and poor five-year survival. As model for human angiosarcoma, we studied primary cells tumorgrafts derived from canine hemangiosarcoma (HSA), which also an malignancy with similar presentation histology. Primary isolated HSA showed constitutive extracellular signal-regulated kinase (ERK) activation. The mitogen-activated protein/extracellular (MEK) inhibitor CI-1040 reduced ERK activation the viability...
To characterize the expression of P-glycoprotein (Pgp) and p53 in different histologic grades canine multicentric lymphosarcoma (LSA), 31 cases LSA without prior treatment were studied. The levels Pgp proteins evaluated for their clinicopathologic significance among standard evaluation. Immunohistochemistry (IHC) was performed on formalin-fixed, paraffin-embedded archival samples previously untreated to detect p53. All dogs subsequently treated with a combination chemotherapy protocol....
Objectives A xenogeneic human tyrosinase DNA vaccine was developed for treatment of dogs with oral malignant melanoma (Oncept; Merial). No studies have evaluated the safety or efficacy this in cats. The purpose study to evaluate canine cats diagnosed melanoma. Methods Medical records were reviewed from and treated (Oncept). Data regarding signalment, location, treatments received, adverse effects cause death collected. Results total 114 vaccines administered 24 Seven (11.4%) had clinical a...
Twenty cats with spontaneously arising tumors received oral lomustine at a dose range of 32 to 59 mg/m2 every 21 days. Due biohazard concerns associated capsule reformulation, standardized 10-mg dosage was used for all regardless body weight. Severe hematological toxicity infrequent, the incidence either grade III or IV neutropenia and thrombocytopenia being 4.1% 1.0%, respectively. Cats receiving higher cumulative doses trended toward greater likelihood progressive (P=0.07). Two lymphoma,...