A5079334291- Veterinary Oncology Research
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Infectious Diseases and Mycology
- Microbial infections and disease research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Mast cells and histamine
- Nail Diseases and Treatments
- Oral and Maxillofacial Pathology
- Cancer and Skin Lesions
- Veterinary Medicine and Surgery
- Ovarian cancer diagnosis and treatment
- Hedgehog Signaling Pathway Studies
- Pancreatic function and diabetes
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Diabetes and associated disorders
- Cancer Genomics and Diagnostics
University of Georgia
2015-2025
Georgia College & State University
2008-2022
Texas A&M University
2017
Colorado State University
2017
Smithsonian Conservation Biology Institute
2017
University of Edinburgh
2017
University of Minnesota
2017
Servier (France)
2015
University of Illinois Urbana-Champaign
2011
University of Wisconsin–Madison
2006-2009
Abstract Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with therapy may therefore yield improved anticancer efficacy over conventional treatments alone. In this study, a fully human anti–IGF-IR monoclonal antibody A12 (ImClone Systems, Inc., New York, NY) examined as an adjunct radiation therapy....
A 14-year-old spayed female domestic shorthair cat presented with an interscapular mass. computed tomography scan, biopsy, and histological examination revealed a fibrosarcoma adjacent to pet identification microchip. Because the was previously vaccinated at this site, it is not possible establish definitive causation of fibrosarcoma, but first report tumor in vicinity microchip cat. Microchip-associated tumors have been reported rodents dogs. Veterinarians should be aware that because...
Abstract Sentinel lymph node evaluation is widely used in human medicine to evaluate the first node(s) which a tumor drains. biopsy allows avoidance of extensive lymphadenectomies cases where sentinel negative for metastasis, thereby reducing patient morbidity. It has been shown that regional nodes are not always node, thus identification and sampling more accurate staging, critical treatment prognostication dogs with cancer. The objective this prospective, pilot study was determine if...
Abstract Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition is biologically achievable with sirolimus, and might slow the outgrowth distant metastases. In this study, pet dogs appendicular osteosarcoma were leveraged high-value biologic models for pediatric osteosarcoma, to assess inhibition therapeutic strategy attenuating disease progression. Patients Methods: A total 324 diagnosed...
The combination of lomustine, L-asparaginase, and prednisone (LAP) is an effective rescue treatment for canine lymphoma (LSA). In a previous study, we reported that remission was typically lost around the time L-asparaginase discontinued.Use with each lomustine will be well tolerated efficacious as therapy LSA.Forty-eight client-owned dogs cytologically confirmed multicentric LSA whose disease had relapsed after cyclophosphamide, doxorubicin, vincristine, prednisone-based chemotherapy...
Abstract Objective —To evaluate outcomes of dogs and owner satisfaction perception their dogs’ adaptation following amputation a thoracic or pelvic limb. Design —Retrospective case series. Animals —64 client-owned dogs. Procedures —Medical records that underwent limb at veterinary teaching hospital between 2005 2012 were reviewed. Signalment, body weight, condition scores the time amputation, dates discharge from hospital, whether was amputated, reason for recorded. Histologic diagnosis date...
Background: Canine lymphoma (LSA) is responsive to initial treatment, however, it then becomes resistant drugs in the protocol. New rescue protocols are needed. Hypothesis: A combination of L-asparaginase, lomustine, and prednisone will be well tolerated efficacious as a therapy for dogs with LSA. Animals: Thirty-one client owned cytologically confirmed multicentric LSA who were refractory or whose disease had relapsed after CHOP (cyclophosphamide/doxorubicin/vincristine/prednisone)-based...
Background : Canine lymphoma (LSA) is responsive to initial treatment, however, it then becomes resistant drugs in the protocol. New rescue protocols are needed. Hypothesis A combination of L‐asparaginase, lomustine, and prednisone will be well tolerated efficacious as a therapy for dogs with LSA. Animals Thirty‐one client owned cytologically confirmed multicentric LSA who were refractory or whose disease had relapsed after CHOP (cyclophosphamide/doxorubicin/vincristine/prednisone)‐based...
Abstract Objective —To identify prognostic factors in a large group of dogs with subcutaneous or intramuscular hemangiosarcoma (HSA) both. Design —Multi-institutional retrospective cohort study. Animals —71 HSA. Procedures —Medical records affected were reviewed. The following evaluated for an association outcome: dog age and sex, clinical signs, anemia, thrombocytopenia, neutrophilia, tumor stage at diagnosis, achievement complete excision, involvement, presence gross disease, recurrence,...
Dysregulation of platelet‐derived growth factor receptor (PDGFR) may play a role in feline injection‐site sarcoma (ISS) cell and viability. Masitinib, tyrosine kinase inhibitor approved for treatment canine mast tumours, is highly selective the PDGFR signalling pathway offer new therapeutic approach this disease. The vitro effects masitinib on growth, apoptosis two novel ISS lines were investigated. expression was confirmed by Western blot derived from primary tumour (JB) corresponding,...
Intralesional chemotherapeutic administration represents an important treatment option for equine cutaneous neoplasia. Tigilanol-tiglate (TT), a novel molecule extracted from Fontainea picrosperma, Australian rainforest plant, is registered intratumoural of canine MCT, leading to rapid oncosis and tumour slough. Evidence horses limited but suggests that efficacy may be similar. To evaluate the response TT in with sarcoids (fibroblastic/nodular) melanomas. Two noncontrolled prospective...
Background : Reports of mammary‐gland tumors in male dogs are lacking. Objective To describe the clinical characteristics dogs. Animals Eight diagnosed with tumors. Methods Retrospective study. Medical databases from 3 institutions were searched. records abstracted, and owners referring veterinarians contacted for follow‐up information. Tissues reviewed histologic type, immunohistochemical staining estrogen progesterone receptors (ER, PR) was performed. Results histologically confirmed...
Background Canine cutaneous T‐cell lymphoma ( CTCL ) is an uncommon disease for which efficacious therapies are lacking. The novel anticancer nucleotide prodrug VDC‐1101 (formerly known as GS‐9219) has shown efficacy in dogs with multicentric lymphoma. One of the observed adverse effects this drug was a skin change characterized by hair loss, erythema, and pruritus, implying delivery to skin. Hypothesis/Objectives primary study objective identify response rate ORR canine ; secondary...
Development of iniparib as an anti-cancer agent was hindered in part by lingering questions regarding its mechanism action, the activity metabolites, and their potential accumulation tumors. Due to strong similarities metabolism between humans dogs, a veterinary clinical trial pet dogs with spontaneous cancers designed answer specific pertaining pharmacokinetic exposures tolerability iniparib. Dogs were treated alone combination carboplatin chemotherapy. Iniparib doses ranged 10–70 mg/kg...
Background: Reports of mammary-gland tumors in male dogs are lacking. Objective: To describe the clinical characteristics dogs. Animals: Eight diagnosed with tumors. Methods: Retrospective study. Medical databases from 3 institutions were searched. records abstracted, and owners referring veterinarians contacted for follow-up information. Tissues reviewed histologic type, immunohistochemical staining estrogen progesterone receptors (ER, PR) was performed. Results: histologically confirmed...
Parathyroid carcinoma (PTC) is rare in dogs and there little information documenting its treatment prognosis. The objective of this study was to describe the outcome with PTC treated surgical excision. Medical records 19 undergoing excision between 1990 2010 were reviewed retrospectively. Dogs presented for clinical hypercalcaemia or incidental noted by referring veterinarians on routine serum chemistry profiles. A parathyroid nodule identified cervical ultrasound 17/17 dogs. Hypercalcaemia...
Rabacfosadine ( RAB ), a novel double prodrug of the acyclic nucleotide phosphonate PMEG , preferentially targets neoplastic lymphocytes with reduced off target toxicity. Historical studies have suggested that every 21‐day dosing is effective acceptable The purpose this study was to evaluate ’s safety and efficacy at 2 different doses 21 days in dogs relapsed B‐cell lymphoma. Dogs had failed 1 doxorubicin‐based chemotherapy protocol were eligible for inclusion prospective trial. Once...
Tumor recurrence following surgery is a common and unresolved medical problem of great importance since the most widely used treatment for solid-mass tumors worldwide. A contributing factor to tumor presence residual remaining at or near surgical site surgery.The primary objective this study was develop evaluate an image-guided system based on near-infrared, handheld excitation source spectrograph in combination with widefield video imaging system.This designed detect fluorescence...