A5033778237- Veterinary Equine Medical Research
- Veterinary Oncology Research
- Renal function and acid-base balance
- Infectious Diseases and Mycology
- Nail Diseases and Treatments
- Nonmelanoma Skin Cancer Studies
- Hemodynamic Monitoring and Therapy
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Veterinary Pharmacology and Anesthesia
- Microbial Inactivation Methods
- Dialysis and Renal Disease Management
- Microbial infections and disease research
- Effects of Radiation Exposure
- Antibiotics Pharmacokinetics and Efficacy
- Oral and Maxillofacial Pathology
- Pharmacological Effects and Assays
- Blood transfusion and management
- Colorectal Cancer Treatments and Studies
- Hypertrophic osteoarthropathy and related conditions
- Diabetes Management and Research
- Bacterial Identification and Susceptibility Testing
- Colorectal Cancer Surgical Treatments
- Diphtheria, Corynebacterium, and Tetanus
- Cutaneous Melanoma Detection and Management
- Dermatologic Treatments and Research
University of Cambridge
2020-2025
Animal Health Trust
2017-2022
Newmarket Equine Hospital
2021
University of Pennsylvania
2008-2015
Irish Equine Centre
2009-2011
Bell Equine Veterinary Clinic
2011
Royal Veterinary College
2006-2008
Reasons for Performing Study: Critical illness is associated with hyperglycemia in humans, and a greater degree duration of nonsurvival. Hypoglycemia also seen critically ill This might be true the foal. Objectives: To investigate association blood glucose concentrations survival, sepsis, systemic inflammatory response syndrome (SIRS). Methods: Blood at admission (515 foals) 24 hours (159 foals), 36 (95), 48 (82), 60 (45) after were analyzed. Logistic regression analyses performed to...
Bacteremia in sick foals is associated with survival, but the association of bacteremia and diarrhea not reported.Neonatal will commonly be bacteremic.One hundred thirty-three neonatal foals.Records all <30 days age presenting between January 1990 September 2007 were reviewed.Sixty-six 133 (50%) bacteremic at admission, 75 isolates from 66 samples. The blood culture a further 18 (13.5%) grew coryneform bacteria. Nine (6.8%) had 2 or more organisms grown on culture. One foal 5 different...
Background : Hyperglycemia in critically ill humans is associated with increased glucose production and insulin resistance death. This might also be true horses presenting acute abdominal disease. Hypothesis Throughout hospitalization, hyperglycemia will common adult a worse prognosis for survival to hospital discharge. Animals Two hundred sixty‐nine Methods Observational retrospective study. Records were reviewed 269 that had data analysed recorded at the time of admission: 154 first sample...
Hyperglycemia in critically ill humans is associated with increased glucose production and insulin resistance death. This might also be true horses presenting acute abdominal disease.Throughout hospitalization, hyperglycemia will common adult disease. a worse prognosis for survival to hospital discharge.Two hundred sixty-nine disease.Observational retrospective study. Records were reviewed 269 that had data analysed recorded at the time of admission: 154 first sample after admission; 110 24...
Background: More information is needed regarding accuracy of commonly used methods glucose measurement in the critically ill horse. Hypothesis: Glucometry will have good agreement with a laboratory standard. plasma better than when performed whole blood. Animals: Fifty sequentially admitted equine emergency patients, aged >1year. Methods: Venous blood was collected at admission and immediately analyzed by point‐of‐care glucometry on both (POC/WB) (POC/PL), multielectrode gas analyzer...
Summary Sino‐nasal neoplasia is rare in horses, and most reports are limited to small numbers of cases, making it challenging draw firm conclusions from the available literature. Exploring data other species often assists equine practitioner better understand diseases but there about sino‐nasal lymphoma species. The association with human herpes virus 4 (Epstein–Barr virus) all reported cases T‐cell humans especially interesting, rarity this tumour horses makes such an extremely investigate.
Intralesional chemotherapeutic administration represents an important treatment option for equine cutaneous neoplasia. Tigilanol-tiglate (TT), a novel molecule extracted from Fontainea picrosperma, Australian rainforest plant, is registered intratumoural of canine MCT, leading to rapid oncosis and tumour slough. Evidence horses limited but suggests that efficacy may be similar. To evaluate the response TT in with sarcoids (fibroblastic/nodular) melanomas. Two noncontrolled prospective...
Neonatal foals succumb rapidly to hypovolaemic shock in comparison mature horses; they do not consistently increase their heart rate response hypotension and respond differently fluid administration. The hormonal responses hypovolaemia the horse foal require investigation.The administration differ between neonatal horses.Five horses 5 fulfilling predetermined criteria for hypovolaemia, were included study. A blood sample was taken at admission after normalisation of balance. These analysed...
Summary There are several differences in treatment of neonatal foals with antimicrobials, compared to mature horses. Firstly, the dose many antimicrobials is different foal. For orally administered drugs, this may also affect their efficacy, due enteral absorption. Secondly, not yet hindgut fermentors and allows a high propensity cause colitis horses be used. Thirdly, toxicities some used horses, such as enrofloxacin, suitable for use foals. Foal‐specific information therefore needed safe...
Summary Periorbital sarcoids are a common condition in the horse and difficult to treat due their location invasive nature. Radiotherapy is considered gold standard treatment, high dose rate brachytherapy ( HDRB ) may represent safer more effective method of delivering radiotherapy standing sedated horse. The objective this retrospective clinical case series study was describe response safety for treatment periorbital Horses ponies referred confirmed were eligible inclusion study. Sarcoids...
Background:Norepinephrine is a potent vasopressor that increases arterial blood pressure but may have adverse effects on renal flow. The combination of norepinephrine and dobutamine lead to improved perfusion compared an infusion alone. these drugs in the normotensive neonatal foal not been reported. Hypothesis:Norepinephrine pressure. Adding will change profile during infusions without changing Animals:Eight conscious Thoroughbred foals were used this study. Methods:Each received (0.1...
Background: Norepinephrine increases arterial blood pressure but may have adverse effects on renal flow. Fenoldopam, a dopamine‐1 receptor agonist, urine output in normotensive foals. The combination of norepinephrine and fenoldopam lead to improved perfusion compared with an infusion alone. combined these drugs not been reported the horse. Hypothesis: will alter hemodynamic profile foals without affecting function. Addition change during infusions changing profile. Animals: Five conscious...
Summary Controversies exist regarding the use, misuse and potential overuse of antimicrobial treatments in foals adults. When antimicrobials are required for treatment infectious diseases, veterinarians should follow a logical approach not simply reach newest drug. Targeted, single drug therapy is probably best, culture sensitivity testing be undertaken. The most likely agent, toxicities, age‐appropriate dose route considered. development an increasing number different multiple resistant...
Norepinephrine is a potent vasopressor that increases arterial blood pressure but may have adverse effects on renal flow. The combination of norepinephrine and dobutamine lead to improved perfusion compared an infusion alone. these drugs in the normotensive neonatal foal not been reported.Norepinephrine pressure. Adding will change profile during infusions without changing pressure.Eight conscious Thoroughbred foals were used this study.Each received (0.1 microg/kg/min), combined...
Background : Fenoldopam mesylate, a dopamine‐1 receptor agonist, has dose‐ and species‐dependent effects on hemodynamics renal function. The of this drug in normotensive neonatal foals have not been reported. Hypothesis Two doses fenoldopam would result distinct changes the systemic circulation, urine output, creatinine clearance foals. Animals Six Thoroughbred Methods Each foal received 2 dosages (low dose, 0.04 μg/kg/min; high 0.4 μg/kg/min) control administration saline, masked,...
To describe a novel surgical technique for management of right dorsal colitis in the horse.Clinical report.14-year-old Warmblood gelding.The horse was referred treatment stromal abscess and signs colitis. Plasma chemistry revealed marked hypoproteinemia. Abdominal ultrasonographic examination showed thickened colon (RDC). Medical unsuccessful. With left lateral recumbency under general anesthesia, an approach to side abdomen through 16th rib resection made. The thoracic cavity entered during...
Summary Periocular tumours are a relatively common problem in the horse, and present some unique challenges. Radiotherapy has long been considered ‘gold standard’ for treatment of periocular there various techniques delivering this treatment. Although teletherapy plesiotherapy occasionally used, most commonly used technique is interstitial brachytherapy. Low‐dose rate brachytherapy reported success rates between 74 100% sarcoids, other can also be successfully treated using technique. There...
Summary Sarcoids are a common condition in the horse. They often difficult to treat and there is no universally effective treatment method. Radiotherapy most consistently successful plesiotherapy may be for carefully selected sarcoid lesions. The objective of this retrospective clinical case series was describe response rate safety strontium equine sarcoids. Horses ponies referred sarcoids were eligible inclusion study diagnosis based solely on features. given total tumour dose 100 Gy under...
SUCCESSFUL fluid therapy in the neonatal foal depends on rapid identification and treatment of hypovolaemia, conjunction with careful monitoring. Clinical signs may be very subtle foal, possibly as a result it being weakest herd member prey species, thus there an evolutionary advantage not showing disease. Added to this, foals do always mount protective physiological response disease states such hypovolaemia. This presents unique challenge clinical deterioration rapid, but also means that...