A5032777429- Veterinary Oncology Research
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Infectious Diseases and Mycology
- Cancer therapeutics and mechanisms
- Cancer Research and Treatments
- Tumors and Oncological Cases
- Tracheal and airway disorders
- Microbial infections and disease research
- Gastrointestinal Tumor Research and Treatment
- Single-cell and spatial transcriptomics
- Biochemical and Molecular Research
- Neuroblastoma Research and Treatments
- Beetle Biology and Toxicology Studies
- Animal Nutrition and Physiology
- Immunotherapy and Immune Responses
- Veterinary Medicine and Surgery
- Radiation Dose and Imaging
- Blood disorders and treatments
- Radioactivity and Radon Measurements
- Bladder and Urothelial Cancer Treatments
- Rabbits: Nutrition, Reproduction, Health
- Gut microbiota and health
- Meta-analysis and systematic reviews
- Proteins in Food Systems
Colorado State University
2014-2025
The Ohio State University
2018
New England Disabled Sports
2014
The updated VCOG-CTCAE v2 guidelines contain several important updates and additions since the last update (v1.1) was released in 2011 published within Veterinary Comparative Oncology 2016. As Cooperative Group (VCOG) is no longer an active entity, original authors contributors to v1.0 v1.1 were consulted for input, additional co-authors sought expansion refinement of adverse event (AE) categories. includes expanded neurology, cardiac immunologic AE sections, addition procedural-specific...
Translationally relevant animal models are essential for the successful translation of basic science findings into clinical medicine. While rodent widely accessible, there numerous limitations that prevent extrapolation to human One approach overcome these is use genetically diverse and naturally develop disease. For example, pet dogs spontaneously diseases recapitulate natural progression seen in humans live similar environments alongside humans. Thus, represent a useful model many areas...
Abstract Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition is biologically achievable with sirolimus, and might slow the outgrowth distant metastases. In this study, pet dogs appendicular osteosarcoma were leveraged high-value biologic models for pediatric osteosarcoma, to assess inhibition therapeutic strategy attenuating disease progression. Patients Methods: A total 324 diagnosed...
Background KIT inhibitors, such as toceranib (TOC), and vinblastine (VBL) have not been prospectively compared in the treatment of macroscopic mast cell tumors (MCTs). Also, it is unknown whether VBL or TOC superior for treating MCT without c-kit mutations. Hypothesis/Objectives To determine value genotyping localization decisions dogs with MCT. We hypothesized that mutated would a better response to than VBL. Animals Eighty-eight client-owned Methods Prospective, randomized trial. Dogs were...
Abstract Purpose: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because their limitations (chemical instability, drug efflux-mediated resistance, diarrhea), novel TOP1 are warranted. Indenoisoquinoline non-camptothecin overcome instability resistance that limit camptothecin use. Three indenoisoquinolines, LMP400 (indotecan), LMP776 (indimitecan), LMP744, were examined in a phase study for...
Canine cutaneous mast cell tumor (MCT) is the most common canine skin and exhibits variable biologic behavior. Signaling through KIT receptor tyrosine kinase promotes cellular proliferation survival has been shown to play a role in MCT progression. Despite investigations into numerous biomarkers proposal of several grading schemas, no single marker or system can accurately predict outcome MCT. The first aim this study was develop an immunohistochemical assay measure phosphorylated (pKIT)...
ABSTRACT Chemotherapy can have adverse gastrointestinal effects in dogs and people. The objective of this study was to assess the impact vincristine prednisolone/prednisone, as part a CHOP chemotherapy [cyclophosphamide, hydroxydaunorubicin, oncovin (vincristine) prednisolone/prednisone] protocol, on dysbiosis with lymphoma. We hypothesised first week (administration VCR/Pred) produces compositional functional shifts canine faecal microbiota that are associated increased dysbiosis. Faecal...
Clinical substage is frequently reported to be prognostic in dogs with lymphoma, yet formal criteria for defining this parameter are lacking. The World Health Organization TNM Classification of Tumors Domestic Animals simply defines as the absence or presence systemic signs (substages a and b, respectively). We designed survey query veterinary oncologists on they use determine clinical practice. Gastrointestinal, constitutional respiratory were most commonly identified factors, greater than...
Many oncolytic viruses that are efficacious in murine cancer models ineffective humans. The outcomes of virus treatment dogs with spontaneous tumors may better predict human response and improve options for cancer. objectives this study were to evaluate the safety myxoma lacking serp2 gene (MYXVΔserp2) determine its immunogenicity dogs. To achieve these objectives, soft tissue sarcomas treated MYXVΔserp2 intratumorally (n = 5) or post-operatively 5). In intratumorally, clinical scores...
Abstract Exocrine pancreatic carcinoma is uncommon in the dog and veterinary literature surrounding disease minimal. Twenty‐three cases of canine exocrine were reviewed a retrospective manner to obtain information on clinical presentation, behaviour survival associated with disease. Presenting signs nonspecific included anorexia, lethargy, vomiting abdominal pain. The overall median time was only 1 day but confounded by large number dogs that euthanized shortly after diagnosis. Metastatic...
Doxorubicin (DOX) area‐under‐the‐curve (AUC) was calculated for 40 dogs with spontaneously occurring cancers using a previously validated limited‐sampling approach. All were administered dose of 30 mg/m 2 by intravenous infusion and serum samples collected at 5, 45 60 minutes post‐infusion. DOX its major metabolite, doxorubicinol (doxol), quantified in high‐performance liquid chromatography tandem‐mass spectrometry. Wide interpatient variability observed the predicted AUC coefficient...
Dry beans (Phaseolus vulgaris L., Fabaceae) are a low glycemic index food containing protein, fiber, minerals, essential vitamins, and bioactive compounds have not been evaluated for inclusion in commercial canine diets. The objective of this study was to establish the apparent total tract digestibility safety cooked navy bean powder when incorporated into diet formulation at 25% (wt/wt) compared with macro- micro-nutrient matched control. Twenty-one healthy, free-living, male female adult...
Abstract Canine cutaneous mast cell tumour (MCT) is the most common malignant skin in dogs and can exhibit variable biologic behaviour. Dysregulated signalling through receptor tyrosine kinase (RTK) KIT promote proliferation survival, assessment of its dysregulation via detection activating c‐kit gene mutations or protein localization associated with multiple features malignancy. The aim current study was to use a previously validated immunohistochemical (IHC) assay directly measure...
This study was performed to determine the ability escalate drug doses in a 15-week CHOP protocol dogs with multicentric lymphoma.We hypothesized that at least 50% of could successfully be escalated 1 drug. Secondary aims were establish objective response rate (ORR), progression-free interval (PFI), and overall survival time (OST).Thirty newly diagnosed lymphoma prospectively treated protocol.This prospective cohort study. Drug did not cause dose-limiting adverse effects (AEs) increased using...
Abstract Background Epidemiologic studies suggest residential radon exposure might increase the risk of primary lung cancer in people, but these are limited by subject mobility. This limitation be overcome evaluating association pets. Hypothesis Primary pulmonary neoplasia (PPN) rate is higher dogs and cats residing counties with a high (Environmental Protection Agency [EPA] zone 1) compared to zones 2 (moderate risk) 3 (low risk). Animals Six hundred ninety client‐owned 205 PPN. Methods...
Abstract Background Rabacfosadine (RAB, Tanovea‐CA1) is a novel chemotherapy agent conditionally approved for the treatment of lymphoma in dogs. Hypothesis/Objectives To determine efficacy and safety RAB dogs with lymphoma. Animals One hundred fifty‐eight client‐owned naïve or relapsed multicentric were prospectively enrolled from January to October 2019. Methods Dogs randomized receive placebo at 3 : 1 ratio. Treatment was given every 21 days up 5 treatments. Study endpoints included...
Abstract The goal of this study was to evaluate the anti‐tumour activity and toxicoses vinorelbine as a palliative rescue therapy for dogs with primary urinary bladder carcinoma. Thirteen refractory prior chemotherapeutics one dog naïve chemotherapeutic treatment were enrolled. Vinorelbine (15 mg m −2 IV ) administered intravenously along concurrent oral anti‐inflammatory drugs, if tolerated. A median six doses (range: 1–16) administered. Two (14%) had partial responses, eight (57%)...
Abstract A male castrated Golden Retriever was presented for evaluation of a large mass over the left shoulder extending to lower part neck that had been present an extended period time, but recent history rapid growth. Previous aspirates were consistent with lipoma. The surgically excised and diagnosed as extraskeletal osteosarcoma based on histopathology. After surgery, dog initiated chemotherapy protocol carboplatin metronomic cyclophosphamide. He became neutropenic, anemic,...
Human rhabdomyosarcomas are rarely cured by surgical resection alone. This is also true for high grade soft tissue sarcomas in dogs. Dogs with spontaneous sarcoma good models clinical responses to new cancer therapies. Strategic combinations of immunotherapy and oncolytic virotherapy (OV) could improve treatment canine human patients. To develop an appropriate combination OV dogs (STS), cells were inoculated myxoma viruses (MYXVs) gene transcripts quantified. Next, cytokine concentrations...
To describe the successful management of cardiac arrest following accidental venous air embolism (VAE) in a cat.A 3-year-old spayed female domestic shorthair cat, weighing 4 kg, was presented for continuation its chemotherapy protocol. The cat inadvertently administered approximately 5.5 mL IV during initiation fluid therapy. Immediate resulted and CPR successfully achieved return spontaneous circulation. discharged 5 days later is reportedly clinically normal 7 months post-discharge.VAE has...
Abstract Background Lymphoma is a common cancer in dogs. While most dogs receiving chemotherapy experience remission, very few are cured, and median survival times generally the 12-month range. Novel approaches to treatment unquestionably needed. The Inhibitor of Apoptosis Protein (IAP) family member survivin, which one commonly overexpressed proteins human cancer, plays key role apoptosis resistance, major cause drug-resistant failure. Survivin targeting therapies have shown promise...
A 3-year-old neutered male Australian Shepherd mix dog presented with metastatic soft tissue sarcoma arising from a primary tumor in the left lumbar fascia. Two separate metastases to lungs were characterized by neoplasia within bronchiolar walls, which caused obstruction of lumina and atelectasis adjacent alveoli, characteristic feature endobronchial metastasis. Neoplastic cells neoplasm, pulmonary lesions, additional widespread masses identified postmortem similarly immunoreactive for...