A5020793867- Child Abuse and Trauma
- Genetics and Neurodevelopmental Disorders
- Child Welfare and Adoption
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Congenital heart defects research
- Homelessness and Social Issues
- Neurotransmitter Receptor Influence on Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Synthesis and Biological Evaluation
- Attention Deficit Hyperactivity Disorder
- Family and Disability Support Research
- Pharmacological Receptor Mechanisms and Effects
- Child Abuse and Related Trauma
- Obesity, Physical Activity, Diet
- Synthesis and Reactivity of Heterocycles
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Child and Adolescent Health
- Chemical Synthesis and Analysis
- Prenatal Substance Exposure Effects
- Phosphodiesterase function and regulation
- Intimate Partner and Family Violence
- Resilience and Mental Health
Center for Child and Family Health
2015-2023
Duke University
2009-2023
Duke University Hospital
2015-2021
Duke Medical Center
2015-2021
New York State College of Veterinary Medicine
2020
Cornell University
2020
Fairfield University
2018
Pfizer (United States)
2010
Princeton University
1999-2009
University of North Carolina at Chapel Hill
2002-2009
Abstract Parent‐ and teacher‐report of attention‐deficit/hyperactivity disorder (ADHD) symptoms were examined using problem behavior DSM‐IV symptom inventory questionnaires for 63 children with full mutation fragile X syndrome (FXS) 56 without disabilities matched on mental age (MA). Prevalence rates ADHD varied depending type measure (problem or criteria), subscale (ADHD‐inattentive ADHD‐hyperactive), scoring method (continuous T‐scores categorical scores based algorithm), rater (parent...
The performance of 54 boys with fragile X syndrome (FXS), ages 7 to 13 years, was compared that a group typically developing who were matched on mental age (MA) and ethnicity across multiple measures executive function (EF). Boys FXS varied in their ability complete EF measures, only 25.9% being able set-shifting task 94.4% memory for word span task. When the control group, controlling MA maternal education, showed significant deficits inhibition, working memory, cognitive...
Phosphodiesterase 10A (PDE10A) is a striatum-enriched, dual-specific cyclic nucleotide phosphodiesterase that has gained considerable attention as potential therapeutic target for psychiatric disorders such schizophrenia. As such, PDE10A-selective inhibitor compound, MP-10, recently entered clinical testing. Since little known about the cellular regulation of PDE10A, we sought to elucidate mechanisms govern its subcellular localization in striatal medium spiny neurons. Previous reports...
Abusive head trauma (AHT) is a serious condition, with an incidence of approximately 30 cases per 100,000 person-years in the first year life.To assess effectiveness statewide universal AHT prevention program.In total, 88.29% parents newborns (n = 405 060) North Carolina received intervention (June 1, 2009, to September 30, 2012). A comparison preintervention and postintervention was performed using nurse advice line telephone calls regarding infant crying (January 2005, December 31, 2010)....
An essential but often overlooked component to promoting trauma-informed care within the child welfare system is educating and empowering foster, adoptive, kinship caregivers (resource parents) with a perspective use in their parenting as well when advocating for services child. In this first evaluation of National Child Traumatic Stress Network's workshop (Caring Children who Have Experienced Trauma, also known Resource Parent Curriculum), participant acceptance satisfaction changes...
Adaptive behavior over time in 70 children with fragile X syndrome, ages 1 to 12 years, was examined using the Vineland Behavior Scales. With a mean of 4.4 assessments per child, adaptive skills increased steadily and gradually time. Children less autistic higher percentages FMPR expression showed better performance on all areas behavior. without displayed scores rates growth Daily Living Skills domain, lowest Socialization. Comparison Brief IQs indicate that syndrome display nonverbal...
Abstract This study examines the developmental changes in nonverbal intellectual functioning evident males with fragile X syndrome (FXS) measured by Leiter International Performance Scales‐Revised (Leiter‐R). The Leiter‐R provides both IQ scores and associated growth which permit examination of age‐based overall growth. Participants were 45 full mutation FXS ranged age from 4.0 to 13.8 years. Each child was assessed annually using as part a larger longitudinal battery for an average 3.5...
Abstract Sustained attention and response inhibition were examined in boys with full mutation fragile X syndrome (FXS) using adapted visual auditory continuous performance tests (CPTs). Only 61% of 56 CPT data 54% 52 able to demonstrate sufficient understanding complete the CPTs, respectively. Mental age (MA) predicted whether FXS CPTs. The who CPTs was compared a sample without disabilities matched on MA. Boys demonstrated similar or smaller declines sustained over task time than their...
The Resource Parent Curriculum (RPC) is a workshop designed to promote trauma-informed parenting among foster, adoptive, and kinship caregivers (i.e., resource parents). ultimate goal of RPC improve placement stability healing from traumatic stress in children who have been placed out-of-home care. current study examined data multiple implementation sites throughout the United States. This used pre- versus postworkshop design assess parents' (n = 314) improvement on parenting, perceived...
Abstract Background Identifying many of the diagnostic criteria for anxiety and depression in individuals with intellectual disability (ID) can be challenging because they may unable to recognize communicate their emotional experiences accurately. The purpose this study is identify behavioural equivalents children fragile X syndrome (FXS), leading inherited cause ID. Methods Parents teachers 43 (aged 6–14 years) full mutation FXS completed two standardized questionnaires on children’s...
5-Hydroxytryptamine (5-HT)<sub>1A</sub> receptors play an important role in multiple cognitive processes, and compelling evidence suggests that 5-HT<sub>1A</sub> antagonists can reverse impairment. We have examined the therapeutic potential of a potent (<i>K</i><sub>i</sub> = 1.1 nM), selective (>100-fold), orally bioavailable, silent receptor antagonist (<i>K</i><sub>B</sub> 1.3 nM) (<i>R</i>)-<i>N</i>-(2-methyl-(4-indolyl-1-piperazinyl)-ethyl)-<i>N</i>-(2-pyridinyl)-cyclohexane...
To describe the early phenotype of girls with full mutation fragile X, we used 54 observations 15 between ages 6 months and 9 years to examine developmental trajectories as measured by Battelle Development Inventory. In this sample, autistic behavior was associated poorer outcomes, primarily due interactions age behavior, even though continuously, relatively mild. Although small ascertained through male relatives X syndrome, limits generalizability, considerable variability in outcome young...
Each year infants die or are permanently disabled at the hands of their caregivers by abusive head trauma, more commonly known as Shaken Baby Syndrome (SBS). Current medical research confirms central role infant crying in triggering shaking caregivers; anecdotally, inconsolable is most common explanation given abusers. Although SBS prevention efforts have been initiated, remain unevaluated. This article provides an overview a 5-year, evidence-based SBS-prevention program called The Period...
Compounds containing a 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2H-1-benzopyran and 3-alkylindole moiety linked through common basic nitrogen were prepared evaluated for 5-HT1A affinity, serotonin rat transporter functional antagonist activity in vitro. 26a was found to be the most potent selective compound this series shown possess neurochemical vivo by producing acute rapid increases 5-HT frontal cortex.
Novel compounds combining a 5-HT1A moiety (3-aminochroman scaffold) and 5-HT transporter (indole analogues) linked through common basic nitrogen via an alkyl chain attached at the 1- or 3-position of indole were evaluated for dual affinity both reuptake site receptor. Compounds most interest found to have 5-carbamoyl-8-fluoro-3-amino-3,4-dihydro-2H-1-benzopyran 3-alkylindole (straight chain), more specifically substituted with 5-fluoro ((R)-(−)-35c), 5-cyano ((−)-52a), 5,7-difluoro...