A5003801834- Cancer Research and Treatments
- Virus-based gene therapy research
- Nanoplatforms for cancer theranostics
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Ear and Head Tumors
- Vascular Tumors and Angiosarcomas
- Renal cell carcinoma treatment
- Tuberous Sclerosis Complex Research
- Neuroendocrine Tumor Research Advances
- Histiocytic Disorders and Treatments
- Bone Tumor Diagnosis and Treatments
- Head and Neck Cancer Studies
- Pituitary Gland Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Cancer Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Soft tissue tumor case studies
- Chromatin Remodeling and Cancer
- Cervical Cancer and HPV Research
- Neuroblastoma Research and Treatments
- Clinical Laboratory Practices and Quality Control
Oregon Health & Science University
2024
The University of Texas MD Anderson Cancer Center
2024
Johns Hopkins Medicine
2018-2022
Johns Hopkins University
2018-2022
Johns Hopkins Hospital
2021-2022
AntiCancer (United States)
2018-2020
University of California, San Diego
2019
Chiang Mai University
2017
Ewing's sarcoma (ES) is a recalcitrant disease in need of transformative therapeutics.The aim this study was to investigate the efficacy tumor-selective Salmonella typhimurium A1-R combined with tumor metabolism targeting oral administration recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model.The PDOX models were previously established right chest wall. The randomized into 5 groups when volume reached 80 mm3: G1: untreated control; G2:...
Abstract Background Ancillary studies are commonly performed on cell blocks prepared from fine‐needle aspiration (FNA) specimens. There limited in application of ancillary salivary gland (SG) FNAs. This multi‐institutional study evaluates the role diagnosis SG lesions, and their impact clinical management. Method The electronic pathology archives three large academic institutions were searched for FNAs with blocks. patient demographics, FNA site, cytologic diagnosis, studies, surgical...
Background/Aim: Undifferentiated pleomorphic sarcoma (UPS) is a common soft tissue and highly recalcitrant. We have previously developed patient-derived orthotopic xenograft (PDOX) mouse models of UPS other major types. Unlike PDOX cancer types, it has been difficult to demonstrate metastasis in the models. Materials Methods: To visualize at high resolution model, established tumor fragments were implanted transgenic nude mice expressing red fluorescent protein (RFP) for one passage. The...
Pleomorphic liposarcoma (PLPS) is the least common but most aggressive of all forms (LPS). Its diagnosis relies on recognition pleomorphic lipoblasts (PLBs), whose numbers vary considerably. Because few large fine-needle aspiration (FNA) biopsy studies exist, authors review their experience with PLPS.The authors' cytopathology files were searched for PLPS histopathologic verification. FNA smears performed via standard techniques.Twenty cases from 20 patients (male/female ratio, 2.3/1; age...
Objective Rapid on‐site evaluation ( ROSE ) has been shown to be beneficial in determining the adequacy and a preliminary diagnosis multiple organ systems. However, little is known regarding diagnostic values agreement of compared with final cytological salivary gland fine needle aspiration FNA ). The aim present study was evaluate compare accuracy between , using histological as gold standard. Methods All patients lesions who underwent during 2009 2013 were evaluated. patient demographic...
Undifferentiated/unclassified soft-tissue sarcomas (USTS) is recalcitrant neoplasms that usually treated with doxorubicin (DOX)-containing regimens as first-line therapy. Nanoparticle albumin-bound paclitaxel (nab-PTX) a nanotechnology-based drug and widely used in pancreatic cancer combination gemcitabine (GEM). The major goal of the present study was to determine efficacy nab-PTX GEM, compared conventional drugs such docetaxel (DOC), GEM combined DOC, or DOX on USTS not-otherwise specified...
Liver metastasis is a recalcitrant disease that usually leads to death of the patient. The present study established unique patient-derived orthotopic xenograft (PDOX) nude mouse model highly aggressive liver colon cancer. aim was demonstrate proof-of-concept candidate drug combinations could significantly inhibit growth and re-metastasis this tumor. patient's initially subcutaneously in mice subcutaneous tumor tissue then orthotopically implanted establish PDOX model. Two studies were...
Background Atypia of undetermined significance (AUS) is a category the Milan System for Reporting Salivary Gland Cytopathology that refers to salivary gland fine‐needle aspiration (FNA) specimens cannot be definitively diagnosed as neoplastic or nonneoplastic. Methods The AUS FNA samples were selected from large academic institution 2008 through 2018. cases divided into 6 subgroups. risk malignancy (ROM), neoplasm (RON), and clinical outcomes each subgroup evaluated. Results A total 123...
Abstract Cancer of unknown primary (CUP) is a recalcitrant disease with poor prognosis because it lacks standard first-line therapy. CUP consists diverse malignancy groups, making personalized precision therapy essential. The present study aimed to identify an effective for patient using patient-derived orthotopic xenograft (PDOX) model. This paper reports the usefulness PDOX model precisely and ineffective chemotherapy compare efficacy S. typhimurium A1-R first use model, which was able...
Solitary fibrous tumour (SFT) is a unique mesenchymal neoplasm with classic features on histology and characterised by the NAB2-STAT6 gene fusion. There are rare reports of SFTs pancreatic involvement only two cases in literature reporting its preoperative fine needle aspiration (FNA). Herein, we characterise cytomorphological four involving pancreas FNA to establish diagnostic approach.The anatomic pathology archives academic medical centres were searched identify patients cytology specimen...