A5001304346- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Soft tissue tumor case studies
- Genetic factors in colorectal cancer
- Tumors and Oncological Cases
- Pancreatic and Hepatic Oncology Research
- Vascular Tumors and Angiosarcomas
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Breast Lesions and Carcinomas
- Musculoskeletal synovial abnormalities and treatments
- Medical Imaging and Pathology Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Ear and Head Tumors
- Cancer and Skin Lesions
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
University of Kentucky
2018-2025
Markey Cancer Center
2021-2025
Albert B. Chandler Hospital
2019-2024
University of New Mexico
2009-2022
New Mexico Cancer Center
2009-2022
UNM Comprehensive Cancer Center
2009-2022
Radiology Associates of Albuquerque
2022
University of Kentucky HealthCare
2020
Frederick National Laboratory for Cancer Research
2019
Emory University
2019
Giant cell tumor (GCT) of bone is a generally benign, but often locally aggressive, neoplasm bone, with propensity for recurrence. Sarcomatous transformation rare and typically occurs history recurrences radiation treatment. Denosumab, an inhibitor the RANK ligand involved in resorption GCT, increasingly used treatment recurrent or unresectable giant bone. We report two cases sarcomatous GCT to osteosarcoma patients receiving denosumab. One was 59-year-old male 12-year multiple taking...
The use of 5-methylcytosine demethylating agents in conjunction with inhibitors histone deacetylation may offer a new therapeutic strategy for lung cancer. Monitoring the efficacy gene treatment directly within tumour be difficult due to location. This study determined positive and negative predictive values sputum serum detecting methylation primary A panel eight genes was evaluated by comparing detected biopsy obtained from 72 patients Stage III prevalence (21–43%) approximated that seen...
Abstract In this report, we present a high-grade thyroid carcinoma with an NSD3::NUTM1 fusion detected on expanded next-generation sequencing testing. Nuclear protein of the testis (NUT) carcinomas comprise high-grade, aggressive tumors characterized by rearrangements NUTM1 gene various partner genes, most commonly bromodomain genes BRD4 and BRD3 . Approximately 10% NUT contain fusion. manifest as poorly differentiated or undifferentiated squamous carcinomas, 33% show areas mature...
Soft tissue tumors (STTs) pose diagnostic and therapeutic challenges due to their rarity, complexity, morphological overlap. Accurate differentiation between benign malignant STTs is important set treatment directions, however, this task can be difficult. The integration of machine learning artificial intelligence (AI) models potentially helpful in classifying these tumors. aim study was investigate AI tools the classification STT into categories. This consisted three components: (1)...
Abstract The prevalence of methylation the p16, DAPK and RASSF1A genes was investigated in lung adenocarcinoma from smokers, former uranium miners never smokers. association between a common genetic alteration adenocarcinoma, mutation K‐ras gene these genes, as well survival examined. Adenocarcinomas 157 46 smokers 34 were evaluated for using methylation‐specific PCR assay. Comparisons also made to prevalences MGMT previously examined tumors. all similar adenocarcinomas although p16 tended...
BackgroundColorectal cancer is a leading cause of cancer-related mortality, has very broad mutational spectrum, and there no clinically available biomarker that can predict which patients with stage II or III colorectal will develop metastatic disease.Patients MethodsWe used targeted next-generation sequencing approach to analyze the spectra in colon patient samples.ResultsAmidst range acquired mutations variants, we found evidence tumor heterogeneity distinguished tumors different groups....
Abstract BACKGROUND The diagnosis of ductal carcinoma in situ (DCIS) is increasing, although to the authors' knowledge there no consensus regarding optimal treatment. This analysis women treated with breast‐conserving surgery (BCS) evaluated impact radiation therapy (RT) patient outcomes. METHODS current study included a population‐based sample 1103 residing selected Surveillance, Epidemiology, and End Results (SEER) registries who were diagnosed DCIS between 1991–1992. Data obtained from...
Despite widespread use of formalin-fixed, paraffin-embedded (FFPE) tissue in clinical and research settings, potential effects variable processing remain largely unknown.To elucidate molecular associated with clinically relevant preanalytical variability, the National Cancer Institute initiated Biospecimen Preanalytical Variables (BPV) program.The BPV program, a well-controlled series systematic, blind randomized studies, investigated whether delay to fixation (DTF) or time fixative (TIF)...
BackgroundNeoadjuvant chemoradiotherapy (nCRT) is the standard of care for locally advanced adenocarcinoma rectum, but it currently unknown which patients have disease that will respond. This study tested correlation between response to nCRT and intratumoral heterogeneity using next-generation sequencing assays.Patients MethodsDNA was extracted from formalin-fixed, paraffin-embedded biopsy samples a cohort with rectal (T3/4 or N1/2 disease) who received nCRT. High read-depth > 400...
We developed a deep learning Pathomics image analysis workflow to generate spatial Tumor-TIL maps visualize and quantify the abundance distribution of tumor infiltrating lymphocytes (TILs) in colon cancer. Colon cancer lymphocyte detection hematoxylin eosin (H&E) stained whole slide images (WSIs) has revealed complex immuno-oncologic interactions that form TIL-rich TIL-poor habitats, which are unique each patient sample. compute Tumor%, total lymphocyte%, TILs% as proportion microenvironment...
Thyroid carcinomas are driven by diverse molecular alterations, but the tumor suppressor gene folliculin (FLCN), best known for its role in Birt-Hogg-Dubé (BHD) syndrome, has received limited attention thyroid tumors. Here, we describe two tumors with pathogenic FLCN alterations-one germline and one somatic-and analyze broader prevalence significance of using multiple large sequencing datasets, including ORIEN-AVATAR. Patient 1, a mutation history BHD presented well-circumscribed oncocytic...
Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide with substantial heterogeneity in patient outcomes. Neurotensin (NT) and its high-affinity receptor (NTR1) have been implicated CRC progression, particularly modulating tumor metabolism immune responses. NT/NTR1 expression has linked to progression outcomes, while gut microbiota increasingly recognized for role development therapy. The purpose current study was explore the relationship between...
Thyroid diseases are common and highly heritable. Under the Global Biobank Meta-analysis Initiative, we performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: cancer, benign nodular goiter, Graves' disease, lymphocytic thyroiditis, primary hypothyroidism. We analyzed genetic data ~2.9 million genomes identified 235 known 501 novel independent variants significantly linked to diseases. discovered correlations between autoimmune (r2=0.21-0.97)....