A5023027117- Genetic Mapping and Diversity in Plants and Animals
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
University of Colorado Boulder
2022-2024
Institute for Behavioral Medicine
2022-2023
Institut de Biologia Evolutiva
2022
Thyroid diseases are common and highly heritable. Under the Global Biobank Meta-analysis Initiative, we performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: cancer, benign nodular goiter, Graves' disease, lymphocytic thyroiditis, primary hypothyroidism. We analyzed genetic data ~2.9 million genomes identified 235 known 501 novel independent variants significantly linked to diseases. discovered correlations between autoimmune (r2=0.21-0.97)....
Abstract Anxiety disorders are common and can be debilitating, with effective treatments remaining hampered by an incomplete understanding of the underlying genetic etiology. Improvements have been made in influences on mouse behavioral models anxiety, yet it is unclear extent to which genes identified these experimental systems contribute variation human anxiety phenotypes. Leveraging new existing large‐scale genome‐wide association studies, we tested whether sets previously anxiety‐like...
It remains unknown to what extent gene-gene interactions contribute complex traits. Here, we introduce a new approach using predicted gene expression perform exhaustive transcriptome-wide interaction studies (TWISs) for multiple traits across all pairs of genes expressed in several tissue types. Using imputed transcriptomes, simultaneously reduce the computational challenge and improve interpretability statistical power. We discover (in UK Biobank) replicate independent cohorts)...
Abstract Both internalizing disorders and alcohol use have dramatic, wide‐spread implications for global health. Previous work has established common phenotypic comorbidity among these disorders, as well shared genetic variation underlying them both. We used genomic structural equation modeling to investigate the genetics of internalizing, externalizing, traits, explore whether specific domains symptoms mediate contrasting relationships with problematic compared consumption. also examined...
Abstract Anxiety disorders are common and can be debilitating, with effective treatments remaining hampered by an incomplete understanding of the underlying genetic etiology. Improvements have been made in influences on mouse behavioral models anxiety, yet it is unclear extent to which genes identified these experimental systems contribute variation human anxiety phenotypes. Leveraging new existing large-scale genome-wide association studies, we tested whether sets previously anxiety-like...
Abstract It remains unknown to what extent gene-gene interactions contribute complex traits. Here, we introduce a new approach using predicted gene expression perform exhaustive transcriptome-wide interaction studies (TWISs) for multiple traits across all pairs of genes expressed in several tissue types. Using imputed transcriptomes, simultaneously reduce the computational challenge and improve interpretability statistical power. We discover replicate associations, find hub with numerous...