Péter Straub
A5069790908- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Neuroscience and Music Perception
- Tryptophan and brain disorders
- Glaucoma and retinal disorders
- Respiratory Support and Mechanisms
- Music and Audio Processing
- BRCA gene mutations in cancer
- Liver Disease Diagnosis and Treatment
- Cardiac Health and Mental Health
- Gothic Literature and Media Analysis
- Peroxisome Proliferator-Activated Receptors
- Retinal Diseases and Treatments
- Bipolar Disorder and Treatment
- Archaeology and ancient environmental studies
- Autism Spectrum Disorder Research
- Diverse Music Education Insights
- Myasthenia Gravis and Thymoma
- Preterm Birth and Chorioamnionitis
- Family and Patient Care in Intensive Care Units
- Genetics and Neurodevelopmental Disorders
- Genetic diversity and population structure
- Genomics and Rare Diseases
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
Vanderbilt University Medical Center
2017-2025
Vanderbilt University
2015-2023
Veszprémi Érseki Hittudományi Fõiskola
2023
Center for Human Genetics
2019
Massachusetts General Hospital
2019
Broad Institute
2019
Göcseji Museum
2017
The LinkedOmics database contains multi-omics data and clinical for 32 cancer types a total of 11 158 patients from Cancer Genome Atlas (TCGA) project. It is also the first that integrates mass spectrometry (MS)-based global proteomics generated by Clinical Proteomic Tumor Analysis Consortium (CPTAC) on selected TCGA tumor samples. In total, has more than billion points. To allow comprehensive analysis these data, we developed three modules in web application. LinkFinder module allows...
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies thoroughly investigated their best practices global populations across different diseases. We here utilized data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological considerations and PRS performance 9 biobanks for 14 disease endpoints. Specifically, we constructed PRSs using pruning thresholding (P + T) PRS-continuous shrinkage (CS). For both methods, a European-based...
Moving in synchrony to the beat is a fundamental component of musicality. Here we conducted genome-wide association study identify common genetic variants associated with synchronization 606,825 individuals. Beat exhibited highly polygenic architecture, 69 loci reaching significance (P < 5 × 10
Background: Epidemiological data suggest the population distribution of thyrotropin (TSH) values is shifted toward lower in self-identified Black non-Hispanic individuals compared with White individuals. It unknown whether genetic differences between similarities to African reference populations (GSA) and those European (GSE) contribute these observed differences. We aimed compare genome-wide associations TSH putative causal TSH-associated variants GSA GSE groups. Methods: performed...
Abstract Background Clinical laboratory (lab) tests are used in clinical practice to diagnose, treat, and monitor disease conditions. Test results stored electronic health records (EHRs), a growing number of EHRs linked patient DNA, offering unprecedented opportunities query relationships between genetic risk for complex quantitative physiological measurements collected on large populations. Methods A total 3075 lab were extracted from Vanderbilt University Medical Center’s (VUMC) EHR system...
Summary Biobanks are being established across the world to understand genetic, environmental, and epidemiological basis of human diseases with goal better prevention treatments. Genome-wide association studies (GWAS) have been very successful at mapping genomic loci for a wide range traits, but in general, lack appropriate representation diverse ancestries - most biobanks preceding GWAS composed individuals European ancestries. Here, we introduce Global Biobank Meta-analysis Initiative...
Although depression is a common psychiatric disorder, its underlying biological basis remains poorly understood. Pairing polygenic scores with the results of clinical laboratory tests can reveal processes involved in etiology and physiological changes resulting from depression.To characterize association between an inflammatory biomarker, ie, white blood cell count.This genetic study was conducted May 19, 2019, to June 5, 2021, using electronic health record data 382 452 patients across 4...
Abstract Background Identifying pregnancies at risk for preterm birth, one of the leading causes worldwide infant mortality, has potential to improve prenatal care. However, we lack broadly applicable methods accurately predict birth risk. The dense longitudinal information present in electronic health records (EHRs) is enabling scalable and cost-efficient modeling many diseases, but EHR resources have been largely untapped study pregnancy. Methods Here, apply machine learning diverse data...
As the collapse of Western Roman Empire accelerated during 4th and 5th centuries, arriving "barbarian" groups began to establish new communities in border provinces declining (and eventually former) empire. This was a time significant cultural political change throughout not only these regions but Europe as whole.1,2 To better understand post-Roman community formation one key frontier zones after Hunnic movement, we generated paleogenomic data for set 38 burials from series three century...
Major depressive disorder (MDD) and loneliness are phenotypically genetically correlated with coronary artery disease (CAD), but whether these associations explained by pleiotropic genetic variants or shared comorbidities is unclear. To tease apart scenarios, we first assessed the medical morbidity pattern associated risk factors for MDD conducting a phenome-wide association study in 18,385 European-ancestry individuals Vanderbilt University Medical Center biobank, BioVU. Polygenic scores...
Eating disorders -including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder-are clinically distinct but exhibit symptom overlap diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first genomic meta-analysis of behaviour (BE; 39,279 cases, 1,227,436 controls), alongside new AN (24,223 1,243,971 controls) its subtypes (all European ancestries). identified six loci associated with BE, including higher body mass index (BMI) impulse-control...
Abstract Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability T2D PRS in diverse populations across various contexts. We characterized a multi-ancestry among 244,637 cases and 637,891 controls eight from Population Architecture Genomics Epidemiology (PAGE) Study 13 additional biobanks cohorts. performance was context dependent, with better those who were...
Background. Neurocognitive impairment (NCI) remains an important complication in persons infected with human immunodeficiency virus (HIV). Ancestry-related mitochondrial DNA (mtDNA) haplogroups have been associated outcomes of HIV infection and combination antiretroviral therapy (CART), neurodegenerative diseases. We hypothesize that mtDNA are NCI HIV-infected adults performed a genetic association study the CNS Antiretroviral Therapy Effects Research (CHARTER) cohort. Methods. CHARTER is...
Thyroid diseases are common and highly heritable. Under the Global Biobank Meta-analysis Initiative, we performed a meta-analysis of genome-wide association studies from 19 biobanks for five thyroid diseases: cancer, benign nodular goiter, Graves' disease, lymphocytic thyroiditis, primary hypothyroidism. We analyzed genetic data ~2.9 million genomes identified 235 known 501 novel independent variants significantly linked to diseases. discovered correlations between autoimmune (r2=0.21-0.97)....
Antidepressants are commonly prescribed medications in the United States, however, factors underlying response poorly understood. Electronic health records (EHRs) provide a cost-effective way to create and test algorithms on large, longitudinal cohorts. We describe new antidepressant algorithm, validation two independent EHR databases, genetic associations with response.
Opioid use disorders (OUDs) constitute a major public health issue, and we urgently need alternative methods for characterizing risk OUD. Electronic records (EHRs) are useful tools understanding complex medical phenotypes but have been underutilized OUD because of challenges related to underdiagnosis, binary diagnostic frameworks, minimally characterized reference groups. As first step in addressing these challenges, new paradigm is warranted that characterizes opioid prescription misuse on...
Abstract Moving in synchrony to the beat is a fundamental component of musicality. Here, we conducted genome-wide association study (GWAS) identify common genetic variants associated with synchronization 606,825 individuals. Beat exhibited highly polygenic architecture, sixty-nine loci reaching significance (p<5×10 −8 ) and SNP-based heritability (on liability scale) 13%-16%. Heritability was enriched for genes expressed brain tissues, fetal adult brain-specific gene regulatory elements,...
Abstract Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness globally. There disparity in POAG prevalence and manifestations across ancestries. We identify novel unique genetics that underlie risk different ancestries by performing meta-analysis 15 biobanks (of the Global Biobank Meta-analysis Initiative) with previously multi-ancestry studies. 18 significant loci, three which were ancestry-specific, five sex-specific identified. performed gene-enrichment...