A5084397937- Genetic Associations and Epidemiology
- Climate Change and Health Impacts
- Obesity, Physical Activity, Diet
- Thermoregulation and physiological responses
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Peroxisome Proliferator-Activated Receptors
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Breastfeeding Practices and Influences
- Cancer Treatment and Pharmacology
- Geriatric Care and Nursing Homes
- Commonwealth, Australian Politics and Federalism
- Menopause: Health Impacts and Treatments
- Effects and risks of endocrine disrupting chemicals
- Microscopic Colitis
- Empathy and Medical Education
- Effects of Radiation Exposure
- Cancer and Skin Lesions
- Urinary Tract Infections Management
Stanford University
2012-2025
VA Palo Alto Health Care System
2021-2024
Stanford Medicine
2019
In the US, normal, oral temperature of adults is, on average, lower than canonical 37°C established in 19 th century. We postulated that body has decreased over time. Using measurements from three cohorts—the Union Army Veterans Civil War (N = 23,710; measurement years 1860–1940), National Health and Nutrition Examination Survey I 15,301; 1971–1975), Stanford Translational Research Integrated Database Environment 150,280; 2007–2017)—we determined mean men women, after adjusting for age,...
Triclosan-a ubiquitous chemical in toothpastes, soaps, and household cleaning supplies-has the potential to alter both gut microbiota endocrine function thereby affect body weight.We investigated relationship between triclosan mass index (BMI) using National Health Nutrition Examination Surveys (NHANES) from 2003-2008. BMI spot urinary levels were obtained adults. Using two different exposure measures-either presence vs. absence or quartiles of triclosan-we assessed association BMI. We also...
Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) explore causal relationships between degree consumption and several in UK Biobank. Using well-established ADH1B Arg47His variant (rs1229984) up 24 additional SNPs recently found be associated with an independent dataset as instruments, we conducted two-stage least...
Abstract Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability T2D PRS in diverse populations across various contexts. We characterized a multi-ancestry among 244,637 cases and 637,891 controls eight from Population Architecture Genomics Epidemiology (PAGE) Study 13 additional biobanks cohorts. performance was context dependent, with better those who were...
Background: In the US, normal, oral temperature of adults is, on average, lower than canonical 37ï‚°C established in 19th century by Wunderlich. We sought to determine whether body has decreased over time.Methods: obtained measurements from three cohorts: Union Army Veterans Civil War (UAVCW, N=23,710; measurement years 1860-1940; men only), National Health and Nutrition Examination I (NHANES, N=15,301; 1971-1975; women), Stanford Translational Research Integrated Database Environment...
Abstract Background A later age at natural menopause (ANM) has been linked to several ageing-associated traits including an increased risk of breast and endometrial cancer a decreased lung cancer, osteoporosis Alzheimer disease. However, ANM is also related proxies for overall health that may confound these associations. Methods We investigated the causal association with clinical outcomes using Mendelian randomization (MR). Participants analysed were restricted post-menopausal females....
Abstract Background The genetic basis for coronary artery disease (CAD) risk is highly complex. Genome-wide polygenic scores (PRS) can help to quantify that risk, but the broader impacts of CAD are not well characterized. Methods We measured using meta genomic score, a previously validated genome-wide PRS, in subset genotyped participants from Women’s Health Initiative and applied phenome-wide association study framework assess associations between PRS broad range blood biomarkers, clinical...
Daily dietary intake data derived from self-reported recall surveys are widely considered inaccurate. In this study, methods were developed for adjusting these recalls to more plausible values. a simulation model of two National Health and Nutrition Examination Surveys (NHANES), NHANES I 2007-2008, predicted one third raw fell outside range physiologically bounds (designated 33% failure rate baseline). To explore the nature magnitude bias, primary obtained an observational study was used...
Breastfeeding has been associated with maternal and infant health benefits but inversely body mass index (BMI) prepartum. BMI are both linked to socioeconomic factors.
Abstract Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization explore causal relationships between degree consumption and several in UK Biobank. found carriers ADH1B Arg47His variant (rs1229984) reported a 26% lower amount compared non-carriers. In our one-sample, two-stage least squares analyses Biobank using rs1229984 as an...
Abstract Background The genetic basis for coronary artery disease (CAD) risk is highly complex. Genome-wide polygenic scores (PRS) can help to quantify that risk, but the broader impacts of CAD are not well characterized. Methods We measured using metaGRS, a previously validated genome-wide PRS, in subset genotyped participants from Women’s Health Initiative (WHI) and applied phenome-wide association study framework assess associations between PRS broad range blood biomarkers, clinical...
Abstract Background A later age at natural menopause (ANM) has been linked to several aging-associated traits including an increased risk of breast and endometrial cancer a decreased lung cancer, osteoporosis, Alzheimer disease. However, ANM is also related proxies for overall health that may confound these associations. Methods We investigated the causal association with clinical outcomes using Mendelian randomization (MR). Participants analyzed were restricted post-menopausal females....
Stanford University, USA, [email protected] USA University School of Medicine,
ABSTRACT In the US, normal, oral temperature of adults is, on average, lower than canonical 37°C established in 19 th century. We postulated that body has decreased over time. Using measurements from three cohorts--the Union Army Veterans Civil War (N=23,710; measurement years 1860-1940), National Health and Nutrition Examination Survey I (N=15,301; 1971-1975), Stanford Translational Research Integrated Database Environment (N=150,280; 2007-2017)--we determined mean men women, after...