Anders Albrechtsen
A5003488251- Genetic Associations and Epidemiology
- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Pancreatic function and diabetes
- Gene expression and cancer classification
- Evolution and Genetic Dynamics
- Bioinformatics and Genomic Networks
- Wildlife Ecology and Conservation
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Genomics and Rare Diseases
- Diabetes and associated disorders
- Nutrition, Genetics, and Disease
- Molecular Biology Techniques and Applications
- Adipose Tissue and Metabolism
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Indigenous Studies and Ecology
- Race, Genetics, and Society
- Forensic Anthropology and Bioarchaeology Studies
- Diet and metabolism studies
University of Copenhagen
2016-2025
Novo Nordisk Foundation
2022
Ilisimatusarfik
2022
Statens Serum Institut
2022
Gentofte Hospital
2018-2020
University of Chicago
2013
Steno Diabetes Centers
2005-2010
Scripps Research Institute
2009
Novo Nordisk (Denmark)
2009
Acupuncture & Integrative Medicine College
2009
High-throughput DNA sequencing technologies are generating vast amounts of data. Fast, flexible and memory efficient implementations needed in order to facilitate analyses thousands samples simultaneously.We present a multithreaded program suite called ANGSD. This can calculate various summary statistics, perform association mapping population genetic utilizing the full information next generation data by working directly on raw or using genotype likelihoods.The open source c/c++ ANGSD is...
We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, represents a male individual first known culture to settle in Greenland. Sequenced average depth 20×, we recover 79% diploid genome, amount close practical limit current sequencing technologies. identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), which 6.8% have not been reported previously. estimate raw read contamination be no higher than 0.8%. use...
Whole-genome data indicate that early modern humans expanded into Australia 62,000 to 75,000 years ago.
Abstract Inference of population structure and individual ancestry is important both for genetics association studies. With next generation sequencing technologies it possible to obtain genetic data all accessible variations in the genome. Existing methods admixture analysis rely on known genotypes. However, genotypes cannot be inferred from low-depth without introducing errors. This article presents a new method inferring an individual’s that takes uncertainty introduced into account....
Abstract Meisner and Albrechtsen present two methods for inferring population structure admixture proportions in low depth next-generation sequencing (NGS). NGS provide large amounts of genetic data but are associated with statistical uncertainty, especially low-depth... We here low-depth (NGS) data. Inference is essential both genetics association studies, often performed using principal component analysis (PCA) or clustering-based approaches. Models can account this uncertainty by working...
How and when the Americas were populated remains contentious. Using ancient modern genome-wide data, we found that ancestors of all present-day Native Americans, including Athabascans Amerindians, entered as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) after more an 8000-year isolation period in Beringia. After their arrival to Americas, ancestral Americans diversified into two basal genetic branches around 13 ka, one is now dispersed across North South...
OBJECTIVE—Three independent studies have shown that variation in the fat mass and obesity-associated (FTO) gene associates with BMI obesity. In present study, effect of FTO on metabolic traits including obesity, type 2 diabetes, related quantitative phenotypes was examined. RESEARCH DESIGN AND METHODS—The rs9939609 polymorphism genotyped a total 17,508 Danes from five different study groups. RESULTS—In 3,856 diabetic case subjects 4,861 normal glucose-tolerant control subjects, minor...
Greenlanders' genomes signal a fatty diet The evolutionary consequences of inhabiting challenging environment can be seen within the Greenland Inuit. Fumagalli et al. have found signs selection for genetic variants in fat metabolism, not just promoting heat-producing brown cells but also coping with large amounts polyunsaturated acids their seafood (see Perspective by Tishkoff). Genes under these populations strong effect on height and weight up to 2 cm 4 kg, respectively, as well protective...
We present a statistical framework for estimation and application of sample allele frequency spectra from New-Generation Sequencing (NGS) data. In this method, we first estimate the spectrum using maximum likelihood. contrast to previous methods, likelihood function is calculated dynamic programming algorithm numerically optimized analytical derivatives. then use Bayesian method estimating in single site, show how can be used genotype calling SNP calling. also extended various other cases...
Chip-based high-throughput genotyping has facilitated genome-wide studies of genetic diversity. Many have utilized these large data sets to make inferences about the demographic history human populations using measures differentiation such as F(ST) or principal component analyses. However, single nucleotide polymorphism (SNP) chip suffer from ascertainment biases caused by SNP discovery process in which a small number individuals selected are used panels. In this study, we investigate effect...
The origin of contemporary Europeans remains contentious. We obtained a genome sequence from Kostenki 14 in European Russia dating 38,700 to 36,200 years ago, one the oldest fossils anatomically modern humans Europe. find that shares close ancestry with 24,000-year-old Mal’ta boy central Siberia, Mesolithic hunter-gatherers, some western Siberians, and many Europeans, but not eastern Asians. Additionally, shows evidence shared population basal all Eurasians also relates later Neolithic...
Present-day hunter-gatherers (HGs) live in multilevel social groups essential to sustain a population structure characterized by limited levels of within-band relatedness and inbreeding. When these wider networks evolved among HGs is unknown. To investigate whether the contemporary HG strategy was already present Upper Paleolithic, we used complete genome sequences from Sunghir, site dated ~34,000 years before present, containing multiple anatomically modern human individuals. We show that...
The New World Arctic, the last region of Americas to be populated by humans, has a relatively well-researched archaeology, but an understanding its genetic history is lacking. We present genome-wide sequence data from ancient and present-day humans Greenland, Arctic Canada, Alaska, Aleutian Islands, Siberia. show that Paleo-Eskimos (~3000 BCE 1300 CE) represent migration pulse into independent both Native American Inuit expansions. Furthermore, continuity characterizing Paleo-Eskimo period...
Revisiting the origins of modern horses The domestication was very important in history humankind. However, ancestry and location timing their emergence remain unclear. Gaunitz et al. generated 42 ancient-horse genomes. Their source samples included Botai archaeological site Central Asia, considered to include earliest domesticated horses. Unexpectedly, were ancestors not domestic horses, but rather Przewalski's Thus, contrast current thinking on horse domestication, may have been other,...
Significance The domestication of the horse revolutionized warfare, trade, and exchange people ideas. This at least 5,500-y-long process, which ultimately transformed wild horses into hundreds breeds living today, is difficult to reconstruct from archeological data modern genetics alone. We therefore sequenced two complete genomes, predating by thousands years, characterize genetic footprint domestication. These ancient genomes reveal predomestic population structure a significant fraction...
Kennewick Man, a 8,500-year-old male human skeleton discovered in Washington state, USA, has been the subject of scientific and legal controversy; here DNA analysis shows that Man is closer to modern Native Americans than any other extant population worldwide. 9,000-year-old USA 1996. The affinities remains have controversy. Initial studies based on morphology suggested was not American affinity. Eske Willerslev colleagues now present showing fact referred as Ancient One by Americans, state...