A5039077702- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Peroxisome Proliferator-Activated Receptors
- Liver Disease Diagnosis and Treatment
- Genomics and Rare Diseases
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Diet and metabolism studies
- Cardiac Ischemia and Reperfusion
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Cannabis and Cannabinoid Research
- Kruppel-like factors research
- RNA regulation and disease
Institut Pasteur de Lille
2011-2025
Centre National de la Recherche Scientifique
2012-2025
Université de Lille
2013-2025
Inserm
1993-2025
European Genomic Institute for Diabetes
2013-2023
Centre Hospitalier Universitaire de Lille
1997-2020
(Epi)génomique fonctionnelle métabolique et des dysfonctions dans le diabète de type 2 et des maladies associées
2020
Institut Pasteur
1997-2014
Université Lille Nord de France
2010-2012
Hôpital Robert-Debré
2012
Non-insulin-dependent diabetes mellitus (NIDDM) is a genetically heterogeneous disorder. Maturity-onset of the young, form NIDDM with an early age onset and autosomal dominant inheritance, can result from mutations in glucokinase, key enzyme glucose metabolism beta cells liver. We studied 32 French families maturity-onset young as well 21 late-onset to determine frequency clinical features glucokinase. Fasting plasma concentrations oral glucose-tolerance tests were used metabolic status. DNA...
The ATP-sensitive potassium (KATP) channel, composed of the beta-cell proteins sulfonylurea receptor (SUR1) and inward-rectifying channel subunit Kir6.2, is a key regulator insulin release. It inhibited by binding adenine nucleotides to which closes activated nucleotide or hydrolysis on SUR1, opens channel. balance these opposing actions determines low open-channel probability, PO, controls excitability pancreatic beta cells. We hypothesized that activating mutations in ABCC8, encodes cause...
KLF11 (TIEG2) is a pancreas-enriched transcription factor that has elicited significant attention because of its role as negative regulator exocrine cell growth in vitro and vivo . However, functional the endocrine pancreas remains to be established. Here, we report, for first time, our knowledge, characterization glucose-inducible insulin gene. A combination random oligonucleotide binding, EMSA, luciferase reporter, chromatin immunoprecipitation assays shows binds promoter regulates...
Several studies have shown that healthy individuals with fasting plasma glucose (FPG) levels at the high end of normal range an increased risk mortality. To identify genetic determinants contribute to interindividual variation in FPG, we tested 392,935 single-nucleotide polymorphisms (SNPs) 654 normoglycemic participants for association and replicated most strongly associated SNP (rs560887, P = 4 × 10 –7 ) 9353 participants. rs560887 maps intron 3 G6PC2 gene, which encodes...
To provide a simple clinical diabetes risk score and to identify characteristics that predict later using variables available in the clinic setting as well biological polymorphisms.Incident was studied 1,863 men 1,954 women, 30-65 years of age at baseline, with defined by treatment or fasting plasma glucose >or=7.0 mmol/l 3-yearly examinations over 9 years. Sex-specific logistic regression equations were used select for prediction.A total 140 63 women developed diabetes. The predictive waist...
Background Maturity-onset of the young (MODY) is a clinically heterogeneous form diabetes characterized by an autosomal-dominant mode inheritance, onset before age 25 years, and primary defect in pancreatic beta-cell function. Approximately 30% MODY families remain genetically unexplained (MODY-X). Here, we aimed to use whole-exome sequencing (WES) four-generation MODY-X family identify new susceptibility gene for MODY. Methodology WES (Agilent-SureSelect capture/Illumina-GAIIx sequencing)...
Permanent neonatal diabetes (PND), requiring insulin within the first months of life, is unexplained at molecular level in most cases. It has very recently been shown that heterozygous activating mutations KCNJ11 gene, encoding Kir6.2 subunit pancreatic ATP-sensitive K+ channel involved regulation secretion, cause PND. In present study, we screened gene for French patients with Patients were recruited through network study diabetes. Seventeen at-term babies a median age diagnosis 64 days...
OBJECTIVE— Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity competitively modulated, with respect to glucose, by binding regulatory protein (GCKR) presence fructose 6-phosphate. Genome-wide association studies for type 2 diabetes identified GCKR as potential locus modulating triglyceride levels. We evaluated, general French population, contribution rs1260326-P446L polymorphism quantitative metabolic parameters dyslipidemia...
The emerging picture of type 2 diabetes genetics involves differently assembled gene variants, each modestly increasing risk with environmental exposure. However, the relevance these genes for disease prediction has not been extensively tested.We analyzed 19 common polymorphisms 14 known candidate their contribution to prevalence and incidence glucose intolerance in DESIR (Data from an Epidemiological Study on Insulin Resistance syndrome) prospective study middle-aged Caucasian subjects,...
OBJECTIVE Heterozygous mutations in the human preproinsulin (INS) gene are a cause of nonsyndromic neonatal or early-infancy diabetes. Here, we sought to identify INS associated with maturity-onset diabetes young (MODY) nonautoimmune mid-adult life, and explore molecular mechanisms involved. RESEARCH DESIGN AND METHODS The was sequenced 16 French probands unexplained MODY, 95 patients early-onset (diagnosed at <35 years) 292 normoglycemic control subjects origin. Three identified...
Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes. We refined signal by direct genotyping examined for associations of variant displaying most independent effect on FPG isolated impaired glycemia (i-IFG), tolerance (i-IGT), diabetes, measures insulin release peripheral hepatic sensitivity.We European-descent participants in Inter99 study (n = 5,553), a sample young healthy Danes...