A5045626839- Genetic Associations and Epidemiology
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Pancreatic function and diabetes
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genomics and Rare Diseases
- Genetic and phenotypic traits in livestock
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Eating Disorders and Behaviors
- Health and Lifestyle Studies
- Gestational Diabetes Research and Management
- RNA modifications and cancer
McMaster University
2015-2025
Impact
2017-2025
Université de Lorraine
2016-2025
Inserm
2016-2025
Laguna Research
2023
Nutrition-Génétique et Exposition aux Risques Environnementaux
2023
Stress Environnementaux et Biosurveillance des Milieux Aquatiques
2023
Centre Hospitalier Régional et Universitaire de Nancy
2020-2021
Institut Pasteur de Lille
2006-2020
Centre National de la Recherche Scientifique
2006-2020
Candidate gene and genome-wide association studies have led to the discovery of nine loci involved in Mendelian forms obesity 58 contributing polygenic obesity. These explain a small fraction heritability for many genes remain be discovered. However, efforts identification greatly modified our understanding this disorder. In review, we propose an overlook major lessons learned from 15 years research field genetics We comment on existence genetic continuum between monogenic that pinpoints...
The emerging picture of type 2 diabetes genetics involves differently assembled gene variants, each modestly increasing risk with environmental exposure. However, the relevance these genes for disease prediction has not been extensively tested.We analyzed 19 common polymorphisms 14 known candidate their contribution to prevalence and incidence glucose intolerance in DESIR (Data from an Epidemiological Study on Insulin Resistance syndrome) prospective study middle-aged Caucasian subjects,...
Advances in genomics technology have led to a dramatic increase the number of published genetic association studies. Systematic reviews and meta-analyses are common method synthesizing findings providing reliable estimates effect variant on trait interest. However, summary subject bias due varying methodological quality individual We embarked an effort develop evaluate tool that assesses Performance characteristics (i.e. validity, reliability, item discrimination) were evaluated using sample...
Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating trajectories remain largely unknown. Here, we modeled longitudinal height Super-Imposition by Translation And Rotation (SITAR) curve analysis on ~ 56,000 trans-ancestry samples repeated measurements from age 5 years to adulthood. We performed six phenotypes representing magnitude, timing, and intensity of pubertal spurt. To investigate lifelong impact variants associated trajectories,...
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a chronic liver disease affecting 25% of the European population, with rising global incidence. damage includes ballooning, steatosis, inflammation and fibrosis. Associated brain disorders include sleep, cognitive issues, anxiety, depression. While neurological complications in advanced MASLD are well documented, early cerebral manifestations remain largely unexplored. This study aimed at developing an rat model to assess...
Considering that a portion of the heterogeneity amongst previous replication studies may be due to variable proportion obese subjects in case-control designs, we assessed association genetic variants with type 2 diabetes (T2D) large groups and non-obese subjects.We genotyped RETN, KCNJ11, HNF4A, HNF1A, GCK, SLC30A8, ENPP1, ADIPOQ, PPARG, TCF7L2 polymorphisms 1,283 normoglycemic (NG) 1,581 T2D individuals as well 3,189 NG 1,244 European descent, allowing us examine risk over wide range...
Obesity is a global health problem that gradually affecting each continent of the world. heterogeneous disorder, and biological causes obesity are complex. The rapid increase in prevalence during past few decades due to major societal changes (sedentary lifestyle, over-nutrition) but who becomes obese at individual level determined great extent by genetic susceptibility. In this review, we evidence strongly heritable provide an update on molecular basis obesity. To date, nine loci have been...