A5009838851- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Pesticide Exposure and Toxicity
- Forensic Toxicology and Drug Analysis
- Chemical Reactions and Isotopes
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Immunotherapy and Immune Responses
- Climate Change and Health Impacts
- Autism Spectrum Disorder Research
- Liver Disease Diagnosis and Treatment
- Microbial bioremediation and biosurfactants
- Ruminant Nutrition and Digestive Physiology
- Monoclonal and Polyclonal Antibodies Research
- Indoor Air Quality and Microbial Exposure
- Pharmacogenetics and Drug Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Energy and Environment Impacts
- Memory and Neural Mechanisms
Université de Lorraine
2006-2025
Inserm
2022-2025
Institut National de Recherche et de Sécurité
2025
Luxembourg Institute of Health
2015-2024
Composés Alimentaires : Biofonctionnalités et risques Neurotoxiques
2019-2023
University of Luxembourg
2011-2023
Nutrition-Génétique et Exposition aux Risques Environnementaux
2022
Laboratoire National de Santé
2006-2014
Laboratoire Animal et Agroécosystèmes
2000-2008
Institut National de la Recherche Agronomique
2007
Electronic cigarette use has raised concern worldwide regarding potential health risks and its position in tobacco cessation strategies. As part of any toxicity assessment, the chemical characterization e-liquids their related vapors are among fundamental data to be determined. Considering lack available reference methods, we developed validated several analytical procedures order conduct a multicomponent analysis six e-liquid refills resultant vapor emissions (generated by smoking machine),...
Urine and plasma have been used to date for the biomonitoring of exposure pollutants are still preferred fluids this purpose; however, these mainly provide information on short term may present a high level variability regarding pesticide concentrations, especially nonpersistent compounds. Hair analysis about chronic that is averaged over several months; therefore, method has proposed as an alternative solely relying fluids. Although possibility detecting pesticides in hair demonstrated past...
As a complex system governing and interconnecting numerous functions within the human body, immune is unsurprisingly susceptible to impact of toxic chemicals. Toxicants can influence through multitude mechanisms, resulting in immunosuppression, hypersensitivity, increased risk autoimmune diseases cancer development. At present, regulatory assessment immunotoxicity chemicals relies heavily on rodent models limited number Organisation for Economic Co-operation Development (OECD) test...
Resorcinol is a widespread substance used in large variety of manufacturing industries, including cosmetics, with endocrine-disrupting activity on the thyroid function. The aim present study was to develop and validate sensitive, selective robust method quantify resorcinol urine thereby assess hairdressers' occupational exposure. As mainly excreted as glucuronide or sulfate forms, first step consisted hydrolyzing samples β-glucuronidase-arylsulfatase enzyme for 16 h. Then, after cleaning...
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a chronic liver disease affecting 25% of the European population, with rising global incidence. damage includes ballooning, steatosis, inflammation and fibrosis. Associated brain disorders include sleep, cognitive issues, anxiety, depression. While neurological complications in advanced MASLD are well documented, early cerebral manifestations remain largely unexplored. This study aimed at developing an rat model to assess...
Recent climate change-induced wildfires and nuclear energy phasing-out policies have fostered atmospheric emissions of polycyclic aromatic hydrocarbons (PAHs).PAHs are pollutants produced by natural anthropic processes under thermal treatment organic matter, e.g. in fires sedimentary rocks (Henner et al. 1997, Lichtfouse 1997).They occur widely the environment from trace levels, polar ice, to high concentrations oil spills.They been found aerosols, soils, sediments, waters, meterorites,...
Polycyclic aromatic hydrocarbons (PAHs), mainly formed by incomplete anthropogenic organic matter combustion, are ubiquitous in the environment. To assess milk PAH contamination sources, samples were collected from tank at farms located near potential contaminating emission sources such as cementworks, steelworks, and motorways. analyses carried out gas chromatography coupled to mass spectrometry. Eight PAHs identified milk: naphthalene, acenaphthylene, acenaphthene, fluorene, anthracene,...
Abstract Early-life adversity covers a range of physical, social and environmental stressors. Acute viral infections in early life are major source such have been associated with broad spectrum later-life effects outside the immune system or “off-target”. These include an altered hypothalamus–pituitary–adrenal (HPA) axis metabolic reactions. Here, we used murine post-natal day 14 (PND 14) Influenza A (H1N1) infection model applied semi-holistic approach including phenotypic measurements,...
An efficient and selective method for the quantitative determination of polycyclic aromatic hydrocarbons (PAHs) their monohydroxylated metabolites (OH-PAHs) in rat brain tissue using gas chromatography tandem (triple quadrupole) mass spectrometry (GC–MS/MS) was developed validated. The list molecules investigated comprised 16 PAHs from US-EPA 53 OH-PAHs. Brain extract submitted to enzymatic hydrolysis, followed by liquid–liquid extraction, then purified solid-phase extraction. Limits...
Fluorene is one of the most abundant polycyclic aromatic hydrocarbons in air and may contribute to neurobehavioral alterations induced by environmental exposure humans PAHs. Since no data are available on fluorene neurotoxicity, this study was conducted adult rats assess behavioral toxicity repeated inhalation exposure. Male (n = 18/group) were exposed nose-only 1.5 or 150 ppb 6 hours/day for 14 consecutive days, whereas control animals non-contaminated air. At end exposure, tested activity...
Abstract Extracellular vesicles (EVs) are membrane-enclosed nanostructures released by cells into the extracellular environment. As major actors of physiological intercellular communication, they have been shown to be pathogenic mediators several liver diseases. also appear potential drug-induced injury but nothing is known concerning environmental pollutants. We aimed study impact polycyclic aromatic hydrocarbons (PAHs), contaminants, on hepatocyte-derived EV production, with a special...
Abstract Besides genetic modifications, rapidly growing evidence has linked environmental pollutants with epigenetic variations. To date, only a few studies have been performed on DNA methylation changes of polycyclic aromatic hydrocarbons (PAH), which showed contradictory results. These discrepancies might be partially explained by differences in used agents. Generally vitro studies, single compound is used, while humans multi-residue exposure investigated. The present study aimed to...
DNA methylation is one of the most important epigenetic modifications and closely related with several biological processes such as regulation gene transcription development non-malignant diseases. The prevailing dogma states that in eukaryotes occurs essentially through 5-methylcytosine (5mC) but recently adenine was also found to be present eukaryotes. In mouse embryonic stem cells, 6-methyladenine (6mA) associated repression silencing genes, particularly X-chromosome, known play an role...
Polycyclic aromatic hydrocarbon (PAH) levels were studied in grass and milk sampled at two farms, one located a non-contaminated, rural area, another urban area close to PAH sources such as highways, busy roads, fuel-powered trains steel plant. concentration measured by gas chromatography coupled mass spectrometry (GC-MS) using internal deuterated standards. In grasses, unexpectedly, although the sum of concentrations was only slightly higher farm (83.1 ± 16.1 ng g −1 ) than (51.8 10.6 ),...
A fast and efficient multiresidue extraction-purification procedure was developed for low levels (ppb range) of phenanthrene hydroxyphenanthrene in biological matrices, order to quantify metabolites blood, milk, urine, tissues lactating goats. Detection identification the analytes (phenanthrene 1-, 2-, 3-, 4-, 9-hydroxyphenanthrene) were achieved using gas chromatography coupled mass spectrometry. Deuterium-labeled used as internal standard 2-OHfluorene metabolites. The method includes...