A5004470927- Nanoparticles: synthesis and applications
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Environmental Toxicology and Ecotoxicology
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Inhalation and Respiratory Drug Delivery
- Heavy Metal Exposure and Toxicity
- Microplastics and Plastic Pollution
- Graphene and Nanomaterials Applications
- Per- and polyfluoroalkyl substances research
- Mycotoxins in Agriculture and Food
- Health, Environment, Cognitive Aging
- Mercury impact and mitigation studies
- Animal testing and alternatives
- Thyroid Disorders and Treatments
- Chemical Analysis and Environmental Impact
- Wildlife Ecology and Conservation
- Climate Change and Health Impacts
- Geochemistry and Elemental Analysis
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Agricultural safety and regulations
- Identification and Quantification in Food
- Recycling and Waste Management Techniques
Luxembourg Institute of Science and Technology
2015-2024
University of Pisa
2022
Iuliu Hațieganu University of Medicine and Pharmacy
2018-2020
National Library of Luxembourg
2013-2015
Laboratoire de Biotechnologie de l'Environnement
2014
Consumers, Health, Agriculture and Food Executive Agency
2009-2014
Norwegian University of Life Sciences
2005-2014
Bharathiar University
2012
Inha University
2012
Norwegian Veterinary Institute
2002-2011
The present opinion deals with an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by Panel to be reliable, including data obtained TiO
One of the key challenges in field nanoparticle (NP) analysis is producing reliable and reproducible characterisation data for nanomaterials. This study looks at reproducibility using a relatively new, but rapidly adopted, technique, Nanoparticle Tracking Analysis (NTA) on range particle sizes materials several different media. It describes protocol development presents both results obtained from 12 laboratories, mostly based Europe, who are primarily QualityNano members. an EU FP7 funded...
Exposure to fine and ultra-fine ambient particles is still a problem of concern in many industrialised parts the world intensified use nanotechnology may further increase exposure small particles. Complex vitro coculture systems be valuable tools study particle-induced processes extrapolate effects on lung. A system consisting four different human cell lines which mimics response alveolar surface was developed native aerosol (Vitrocell™ chamber). The composed an type-II line (A549),...
For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the individual chemical environment is expected enhance understanding threats health.We developed and applied harmonized protocol collect comparable human biomonitoring all over Europe.In 17 European countries, we measured mercury in hair cotinine, phthalate metabolites, cadmium urine 1,844 children (5-11 years age) their mothers. Specimens were collected 5-month period...
The transport and the delivery of drugs through nanocarriers is a great challenge pharmacology. Since production liposomes to reduce toxicity doxorubicin in patients, plethora nanomaterials have been produced characterized. Although it widely known that elementary properties influence their vivo kinetics, such interaction often poorly investigated many preclinical studies. present study aims evaluate actual effect size shape on biodistribution set gold nanoparticles (GNPs) after intravenous...
The toxicity of methylmercury (MeHg) in humans is well established and the main source exposure via consumption large marine fish mammals. Of particular concern are potential neurodevelopmental effects early life to low-levels MeHg. Therefore, it important that pregnant women, children women childbearing age are, as far possible, protected from MeHg exposure. Within European project DEMOCOPHES, we have analyzed mercury (Hg) hair 1799 mother-child pairs 17 countries using a strictly...
Interactions between nanoparticles and cells are now the focus of a fast-growing area research. Though many interact with without any acute toxic responses, metal oxide including those composed titanium dioxide (TiO2-NPs) may disrupt intracellular process macroautophagy. Autophagy plays key role in human health disease, particularly cancer neurodegenerative diseases. We herein investigated vitro biological effects TiO2-NPs (18 nm) on autophagy keratinocytes (HaCaT) at non-cytotoxic levels....
The increased incorporation of silver nanoparticles (Ag NPs) into consumer products makes the characterization potential risk for humans and other organisms essential. oral route is an important uptake NPs, therefore study gastrointestinal tract in respect to NP toxicity very timely. aim present was evaluate effects Ag NPs ions on a Caco-2/TC7:HT29-MTX intestinal co-culture model with mucus secretion, which constitutes protective barrier exogenous agents vivo may strongly influence particle...
The EFSA Panel on Contaminants in the Food Chain (CONTAM) established a tolerable daily intake (TDI) for fumonisin B
As a complex system governing and interconnecting numerous functions within the human body, immune is unsurprisingly susceptible to impact of toxic chemicals. Toxicants can influence through multitude mechanisms, resulting in immunosuppression, hypersensitivity, increased risk autoimmune diseases cancer development. At present, regulatory assessment immunotoxicity chemicals relies heavily on rodent models limited number Organisation for Economic Co-operation Development (OECD) test...
Polychlorinated biphenyls (PCBs) and a number of pesticides can act as endocrine disrupting compounds (EDCs). These molecules exhibit hormonal activity in vivo, therefore interact perturb normal physiological functions. Many these are persistent the environment, their bioaccumulation may constitute significant threat for human health. Physiological abnormalities following exposure to xenobiotic go along with alterations at protein level individual cells. In this study, MCF-7 cells were...
The EFSA Panel on Contaminants in the Food Chain (CONTAM) established a tolerable daily intake (TDI) for T2 and HT2 of 0.02 μg/kg body weight (bw) per day based new
The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term exposure, but insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults developmental children. This study first pan-European human biomonitoring project that succeeded performing harmonized measurements Cd urine comparable way mother-child couples 16 European countries. aim was to evaluate...
During the last 250 years, level of exposure to combustion-derived particles raised dramatically in western countries, leading increased particle loads ambient air. Among environmental particles, diesel exhaust particulate matter (DEPM) plays a special role because its omnipresence and reported effects on human health. recent possible link between air pollution progression atherosclerosis is recognized. A central effect DEPM their impact endothelium, especially alveolar barrier. In present...
Exposure to traffic-derived particulate matter (PM), such as diesel exhaust particles (DEP), is a leading environmental cause of cardiovascular disease (CVD), and may contribute endothelial dysfunction development atherosclerosis. It still debated how DEP other inhaled PM can CVD. However, organic chemicals (OC) adhered the particle surface, are considered central many biological effects. In present study, we have explored ability OC from reach endothelium trigger pro-inflammatory reactions,...