A5040719852- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Plant and fungal interactions
- Sleep and Wakefulness Research
- Sleep and related disorders
- Plant Pathogens and Fungal Diseases
- Wheat and Barley Genetics and Pathology
- Microbial infections and disease research
- Agricultural safety and regulations
- Plant Disease Resistance and Genetics
- Veterinary medicine and infectious diseases
- Animal Nutrition and Physiology
- Meat and Animal Product Quality
- Parasites and Host Interactions
- Indoor Air Quality and Microbial Exposure
- Probiotics and Fermented Foods
- Gut microbiota and health
- Insect and Pesticide Research
- Rabbits: Nutrition, Reproduction, Health
- Immune Response and Inflammation
- Fungal Biology and Applications
- Plant Toxicity and Pharmacological Properties
- Immunotoxicology and immune responses
- Pesticide Residue Analysis and Safety
- Phytochemicals and Antioxidant Activities
Toxalim Research Centre in Food Toxicology
2016-2025
Université Toulouse III - Paul Sabatier
2016-2025
École Nationale Vétérinaire de Toulouse
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2008-2025
Université de Toulouse
2015-2024
Universidad Nacional Autónoma de México
2023
Yangzhou University
2023
Université de Montréal
2023
Institut National de la Recherche Agronomique du Niger
2002-2020
Institut National de la Recherche Agronomique
2006-2016
Abstract IL-10, a cytokine produced by CD4+ T lymphocytes belonging to the Th-2 subset, has previously been shown inhibit synthesis of IFN-gamma both cells and NK cells. We now demonstrate that IL-10 can also down-regulate IFN-gamma-dependent immunity blocking ability lymphokine activate macrophages. Thus, in dose-dependent manner, inhibits microbicidal activity IFN-gamma-treated inflammatory macrophages against intracellular Toxoplasma gondii as well extracellular killing schistosomula...
The present study was carried out to determine the effector mechanism of anti-Trypanosoma cruzi activity by interferon (IFN)-gamma plus lipopolysaccharide (LPS)-treated macrophages. A macrophage cell line (IC-21) that failed mount an appreciable oxidative burst nevertheless found able control T. growth after exposure IFN-gamma alone or LPS. Moreover, microbicidal functions both inflammatory macrophages and IC-21 against be inhibited in presence NG-monomethyl-L-arginine (NGMMA), a competitive...
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic (PFOA) in food. Regarding PFOS PFOA occurrence, final data set available dietary exposure assessment contained total 20,019 analytical results (PFOS n = 10,191 9,828). There were large differences between upper lower bound due methods with insufficient sensitivity. CONTAM Panel considered estimates be closer true levels....
After activation with IFN-gamma, thioglycollate-elicited murine peritoneal macrophages kill schistosomula of Schistosoma mansoni in vitro by an L-arginine-dependent mechanism which involves the production reactive nitrogen oxides (NO). In present study we demonstrate that regulatory cytokines IL-10, IL-4, and transforming growth factor-beta (TGF-beta) are potent inhibitors this extracellular killing function activated macrophages. Each cytokine was found to suppress a dose-dependent fashion....
Deoxynivalenol (DON) is a mycotoxin primarily produced by Fusarium fungi, occurring predominantly in cereal grains. Following the request of European Commission, CONTAM Panel assessed risk to animal and human health related DON, 3-acetyl-DON (3-Ac-DON), 15-acetyl-DON (15-Ac-DON) DON-3-glucoside food feed. A total 27,537, 13,892, 7,270 2,266 analytical data for 3-Ac-DON, 15-Ac-DON DON-3-glucoside, respectively, food, feed unprocessed grains collected from 2007 2014 were used. For exposure,...
EFSA was asked to deliver a scientific opinion on the risks public health related presence of aflatoxins in food. The risk assessment confined aflatoxin B1 (AFB1), AFB2, AFG1, AFG2 and AFM1. More than 200,000 analytical results occurrence were used evaluation. Grains grain-based products made largest contribution mean chronic dietary exposure AFB1 all age classes, while 'liquid milk' 'fermented milk products' main contributors AFM1 exposure. Aflatoxins are genotoxic can cause hepatocellular...
Most fungi are able to produce several mycotoxins simultaneously; moreover food and feed can be contaminated by species at the same time. Thus, humans animals generally not exposed one mycotoxin but toxins of studies concerning toxicological effect have been carried out taking into account only mycotoxin. In present review, we analysed 112 reports where laboratory or farm were a combination mycotoxins, determined for each parameter measured type interaction that was observed. published...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of dioxins (PCDD/Fs) DL-PCBs in feed food. data from experimental epidemiological studies were reviewed it was decided base risk assessment effects observed humans use as supportive evidence. critical effect semen quality, following pre- postnatal exposure. study showed NOAEL 7.0 pg WHO
Deoxynivalenol (DON) and fumonisins (FB) are mycotoxins produced by Fusarium species, which naturally co-occur in animal diets. The gastrointestinal tract represents the first barrier met exogenous food/feed compounds. purpose of present study was to investigate effects DON FB, alone combination, on some intestinal parameters, including morphology, histology, expression cytokines junction proteins. A total twenty-four 5-week-old piglets were randomly assigned four different groups, receiving...
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Zearalenone (ZEN), a mycotoxin primarily produced by Fusarium fungi, occurs predominantly in cereal grains.The European Commission asked EFSA for scientific opinion on the risk to animal health related ZEN and its modified forms feed.Modified of occurring feed include phase I metabolites a-zearalenol (a-ZEL), b-zearalenol (b-ZEL), a-zearalanol (a-ZAL), b-zearalanol (b-ZAL), zearalanone (ZAN) II conjugates.ZEN has oestrogenic activity differs considerably.For ZEN, Panel Contaminants Food...
EFSA was asked by the European Commission to deliver a scientific opinion on risks for human health related presence of pyrrolizidine alkaloids (PAs) in honey, tea, herbal infusions and food supplements identify PAs relevance aforementioned commodities other feed food. are large group toxins produced different plant species. In 2011, Panel Contaminants Food Chain (CONTAM Panel) assessed feed. Based occurrence data limited CONTAM concluded that there possible concern those toddlers children...
Interleukin 10 (IL-10) inhibits interferon gamma-induced macrophage activation for cytotoxicity against larvae of the human parasite Schistosoma mansoni by suppressing production toxic effector molecule nitric oxide (NO). In this study, mechanism IL-10 action was identified as inhibition endogenous tumor necrosis factor alpha (TNF-alpha) gamma-activated macrophages. TNF-alpha appears to serve a cofactor gamma-mediated activation, since both schistosomulum killing and NO were inhibited...