A5034364029- Agricultural safety and regulations
- Immunotoxicology and immune responses
- Occupational exposure and asthma
- Animal testing and alternatives
- Effects and risks of endocrine disrupting chemicals
- Contact Dermatitis and Allergies
- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Carcinogens and Genotoxicity Assessment
- Skin Protection and Aging
- Recycling and Waste Management Techniques
- Food Allergy and Anaphylaxis Research
- Consumer Attitudes and Food Labeling
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Nanoparticles: synthesis and applications
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Dermatology and Skin Diseases
- Climate Change and Health Impacts
- Mast cells and histamine
- Environmental Policies and Emissions
- Medical and Biological Ozone Research
- Toxic Organic Pollutants Impact
- Indoor Air Quality and Microbial Exposure
Federal Ministry of Social Affairs, Health, Care and Consumer Protection
2023
Ministère de l'Économie et des Finances
2022
Federal Office of Consumer Protection and Food Safety
2020-2021
Maastricht University
2011-2020
Maastricht University Medical Centre
2011-2020
Netherlands Food and Consumer Product Safety Authority
2020
National Institute for Public Health and the Environment
2009-2018
Academy of Nutrition and Dietetics
2017
University of Zurich
2017
Netherlands Metabolomics Centre
2016
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluoroalkyl substances (PFASs) in food. Based several similar effects animals, toxicokinetics and observed concentrations blood, CONTAM Panel decided perform assessment sum four PFASs: PFOA, PFNA, PFHxS PFOS. These made up half lower bound (LB) exposure those PFASs with available occurrence data, remaining contribution being primarily from short half-lives. Equal potencies were...
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic (PFOA) in food. Regarding PFOS PFOA occurrence, final data set available dietary exposure assessment contained total 20,019 analytical results (PFOS n = 10,191 9,828). There were large differences between upper lower bound due methods with insufficient sensitivity. CONTAM Panel considered estimates be closer true levels....
Perfluoroalkyl substances (PFAS) are suggested to have immunosuppressive effects; exposure in utero and the first years of life is special concern as fetuses small children highly vulnerable toxicant exposure. The objective this study was investigate effect pre-natal PFAS on responses pediatric vaccines immune-related health outcomes up 3 age. In prospective birth-cohort BraMat, a sub-cohort Norwegian Mother Child Cohort Study (MoBa), pregnant women from Oslo Akershus, Norway, were recruited...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of dioxins (PCDD/Fs) DL-PCBs in feed food. data from experimental epidemiological studies were reviewed it was decided base risk assessment effects observed humans use as supportive evidence. critical effect semen quality, following pre- postnatal exposure. study showed NOAEL 7.0 pg WHO
Following a request from the European Commission, EFSA developed an updated scientific guidance to assist applicants in preparation of applications for food enzymes. This describes data be included authorisation enzymes, as well extension use existing authorisations, accordance with Regulation (EC) No 1331/2008 and its implementing rules. Information provided relates source, production characteristics enzyme, toxicological data, allergenicity dietary exposure estimation. Source, enzyme are...
Because of its antibacterial activity nanosilver is one the most commonly used nanomaterials. It increasingly in a variety both medical and consumer products resulting an increase human exposure. However, knowledge on systemic toxicity relatively limited. To determine potential silver nanoparticles (Ag-NP) with different sizes (20 nm 100 nm) 28-days repeated dose study was performed rats using intravenous administration. The toxic effect 20 Ag-NP bench mark (BMD) approach. Treatment maximum...
In 2015, EFSA established a temporary tolerable daily intake (t-TDI) for BPA of 4 μg/kg body weight (bw) per day. 2016, the European Commission mandated to re-evaluate risks public health from presence in foodstuffs and establish (TDI). For this re-evaluation, pre-established protocol was used that had undergone consultation. The CEP Panel concluded it is Unlikely Very presents genotoxic hazard through direct mechanism. Taking into consideration evidence animal data support human...
The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP Panel) was asked by the European Commission to update its 2005 risk assessments of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) di-isodecylphthalate (DIDP), which are authorised for use in plastic food contact material (FCM). Dietary exposure estimates (mean high (P95)) were obtained combining literature occurrence data with consumption from...
The present opinion deals with an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by Panel to be reliable, including data obtained TiO
Following a request from the European Commission, EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for vitamin K. In this Opinion, considers K to comprise both phylloquinone menaquinones. The that none of biomarkers intake or status is suitable by itself derive DRVs Several health outcomes possibly associated with were also considered but data could not be used establish DRVs. average requirements population intakes cannot derived adults,...
This document is intended to assist the applicant in preparation
Although silver nanoparticles are currently used in more than 400 consumer products, it is not clear to what extent they induce adverse effects after inhalation during production and use. In this study, we determined the lung burden, tissue distribution, induction recovery of short-term exposure 15 nm 410 nanoparticles. Rats were nose-only exposed clean air, (179 μg/m3) or particles (167 6 hours per day, for four consecutive days. Tissue distribution pulmonary toxicity at 24 7 days compared...
Food enzymes are used for technical purposes in the production of food ingredients or foods-as-consumed. In European Union, safety a enzyme is evaluated by EFSA on basis dossier provided an applicant. Dietary exposure integral part risk assessment enzymes. To develop models specific to each manufacturing process which used, different input data required then tandem with conversion factors. This allows use levels be related consumption collected dietary surveys. For process, identified list...
Recent mass mortalities among several marine mammal populations have led to speculation about increased susceptibility viral infections as a result of contaminant-induced immunosuppression. In 2.5-year study, we fed herring from either the relatively uncontaminated Atlantic Ocean or contaminated Baltic Sea two groups captive harbor seals and monitored immune function in seals. Seals fish were less able mount specific immunological response ovalbumin, measured by vivo delayed-type...
Human population data on air pollution and its effects the immune system are scarce. A survey was conducted within framework of Central European Study Air Quality Respiratory Health (CESAR) to measure a panel biomarkers in children Bulgaria, Czech Republic, Hungary, Poland, Romania, Slovakia. Seventeen cities were chosen represent wide range exposure outdoor pollution. In each, ambient particulate matter less than 10 microns diameter 2.5 (PM10 PM2.5) measured with Harvard impactor. Blood...
In this study the role of interleukin (IL)4, IL5, interferon (IFN) gamma, and tumor necrosis factor (TNF) alpha in development airway hyperresponsiveness inflammatory cell infiltration was investigated using a murine model for allergic asthma. Mice were sensitized with ovalbumin subsequently challenged repeatedly aerosols. During challenge period, mice treated monoclonal antibodies directed against IL4, IFN or TNF alpha. Control antibody-treated showed to methacholine presence eosinophils...
Since 1969, the European Union approves food-grade titanium dioxide (TiO2), also known as E171 colouring food additive. is a mixture of micro-sized particles (MPs) and nano-sized (NPs). Previous studies have indicated adverse effects oral exposure to E171, i.e. facilitation colon tumour growth. This could potentially be partially mediated by capacity induce reactive oxygen species (ROS). The aim present study determine whether induces ROS formation DNA damage in an vitro model using human...
In four different systems it was shown that murine delayed-type hypersensitivity (DTH) responses at 18-48 h were preceded by early 2-h responses. CBA mice immunized with picryl chloride, BDF1 oxazolone, BALB/c dinitrofluorobenzene, and C57BL/6 L5178Y lymphoma cells, challenged the appropriate specific antigen, all gave rise to expected delayed-in-time reactions, but of these reactions peaked 2 h. These are transferable T cells or a cell-derived, antigen-binding factor antigen-specific. The...
Optimal functioning of the immune system is crucial to human health, and nutrition one major exogenous factors modulating different aspects function. Currently, no single marker available predict effect a dietary intervention on To provide further guidance assessment interpretation modulation functions due in general population, International Life Sciences Institute Europe commissioned group experts from academia, government food industry prepare document. A draft this paper was refined at...