A5013274066- Agricultural safety and regulations
- Effects and risks of endocrine disrupting chemicals
- Chromosomal and Genetic Variations
- Pesticide Residue Analysis and Safety
- Sperm and Testicular Function
- Genomic variations and chromosomal abnormalities
- Reproductive Biology and Fertility
- Mycotoxins in Agriculture and Food
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- RNA Research and Splicing
- Toxic Organic Pollutants Impact
- Animal Genetics and Reproduction
- Prenatal Screening and Diagnostics
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cassava research and cyanide
- DNA Repair Mechanisms
- Plant-based Medicinal Research
- Chromium effects and bioremediation
- Renal and related cancers
- Bioactive Natural Diterpenoids Research
- Nuclear Structure and Function
Centro de Investigaciones Biológicas Margarita Salas
2013-2024
Consejo Superior de Investigaciones Científicas
2000-2021
Istituto Superiore di Sanità
2020
National Research Council
2013-2019
Universidad Nacional del Sur
2013
California Institute of Technology
1990
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluoroalkyl substances (PFASs) in food. Based several similar effects animals, toxicokinetics and observed concentrations blood, CONTAM Panel decided perform assessment sum four PFASs: PFOA, PFNA, PFHxS PFOS. These made up half lower bound (LB) exposure those PFASs with available occurrence data, remaining contribution being primarily from short half-lives. Equal potencies were...
EFSA was asked to deliver a scientific opinion on the risks public health related presence of aflatoxins in food. The risk assessment confined aflatoxin B1 (AFB1), AFB2, AFG1, AFG2 and AFM1. More than 200,000 analytical results occurrence were used evaluation. Grains grain-based products made largest contribution mean chronic dietary exposure AFB1 all age classes, while 'liquid milk' 'fermented milk products' main contributors AFM1 exposure. Aflatoxins are genotoxic can cause hepatocellular...
The European Commission asked EFSA to update their 2006 opinion on ochratoxin A (OTA) in food. OTA is produced by fungi of the genus
The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance newly available scientific information.More than 47,000 analytical results of were used for calculating chronic acute dietary exposure.An increased incidence postimplantation loss rats was identified as critical effect risk characterisation oral exposure a BMDL 10 1.3 mg Ni/kg body weight (bw) per day...
EFSA was asked for a scientific opinion on the risks to public health related presence of
The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard of inorganic (iAs) and using the revised exposure issued by 2021. Epidemiological studies show that chronic intake iAs via diet and/or drinking water is associated with increased several adverse outcomes including cancers skin, bladder lung. CONTAM Panel used benchmark dose lower confidence limit based response (BMR) 5% (relative increase background incidence after adjustment for...
The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing 10 congeners: BDE-28, -47, -49, -99, -100, -138, -153, -154, -183 and ‑209. CONTAM Panel concluded that the neurodevelopmental effects behaviour reproductive/developmental are critical rodent studies. For four congeners (BDE-47, -209) derived Reference Points, i.e. benchmark doses corresponding lower 95% confidence limits (BMDLs), for endpoint-specific responses....
In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of male germline and induce transgenerational epigenetic disorders. The anti-androgenic compound vinclozolin represents a paradigmatic example molecule causing effects on cells. We performed prenatal mice analyzed phenotypic molecular changes three successive...
In 2016, the EFSA Panel on Contaminants in Food Chain (CONTAM) published a scientific opinion acute health risks related to presence of cyanogenic glycosides (CNGs) raw apricot kernels which an reference dose (ARfD) 20 μg/kg body weight (bw) was established for cyanide (CN). present opinion, CONTAM concluded that this ARfD is applicable effects CN regardless dietary source. To account differences bioavailability after ingestion certain food items, specific factors were used. Estimated mean...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of quinolizidine alkaloids (QAs) in feed food. This risk assessment is limited QAs occurring Lupinus species/varieties relevant consumption Europe (i.e. albus L., angustifolius luteus L. mutabilis Sweet). Information toxicity animals humans limited. Following acute exposure sparteine (reference compound), anticholinergic effects changes cardiac electric conductivity are...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of glycoalkaloids (GAs) in feed food. This risk assessment covers edible parts potato plants other food containing GAs, particular, tomato aubergine. In humans, acute toxic effects GAs (α-solanine α-chaconine) include gastrointestinal symptoms such as nausea, vomiting diarrhoea. For these effects, CONTAM Panel identified lowest-observed-adverse-effect level 1 mg total GAs/kg...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of chlorinated paraffins in feed food. data experimental animals were reviewed CONTAM Panel identified liver, kidney thyroid as target organs SCCP MCCP mixtures tested repeated dose toxicity studies. Decreased pup survival subcutaneous haematoma/haemorrhage also critical effects an mixture. For LCCP tested, liver was organ. selected reference points BMDL 10 2.3 mg/kg bw per...
In 2018, the EFSA Panel on Contaminants in Food Chain (CONTAM) adopted a Scientific Opinion risks for animal health related to presence of fumonisins, their modified forms and hidden feed. A no observed adverse effect level (NOAEL) 1 mg/kg feed was established pigs. poultry NOAEL 20 horses reference point 8.8 established, referred as NOAEL. The European Commission (EC) requested review information regarding toxicity fumonisins pigs, revise, if necessary, NOAELs. CONTAM considered that term...
The European Commission asked EFSA to update its 2011 risk assessment on tetrabromobisphenol A (TBBPA) and five derivatives in food. Neurotoxicity carcinogenicity were considered as the critical effects of TBBPA rodent studies. available evidence indicates that occurs via non-genotoxic mechanisms. Taking into account new data, CONTAM Panel it appropriate set a tolerable daily intake (TDI). Based decreased interest social interaction male mice, lowest observed adverse effect level (LOAEL) 0.2...
Chromatin rearrangements in the meiotic prophase are characterized by assembly and disassembly of synaptonemal complexes (SC), a protein structure that stabilizes pairing homologous chromosomes prophase. We report identification human mouse cDNA coding for stromalin 3 (STAG3), new mammalian member complex. The stroma-lins group highly conserved proteins, represented several organisms from yeast to humans. Stromalins conservative domain (SCD), specific motif found all proteins family...
In 2004, the EFSA Panel on Contaminants in Food Chain (CONTAM) adopted a Scientific Opinion risks to animal health and transfer from feed food of origin related presence ochratoxin A (OTA) feed. The European Commission requested assess newly available scientific information update 2004 Opinion. OTA is produced by several fungi genera Aspergillus Penicillium. most species it rapidly extensively absorbed gastro-intestinal tract, binds strongly plasma albumins mainly detoxified alpha (OTalpha)...
Mineral oil hydrocarbons (MOH) are composed of saturated (MOSH) and aromatic (MOAH). Due to the complexity MOH composition, their complete chemical characterisation is not possible. MOSH accumulation observed in various tissues, with species-specific differences. Formation liver epithelioid lipogranulomas inflammation, as well increased spleen weights, Fischer 344 (F344) rats, but Sprague-Dawley (SD) rats. These effects related specific wax components F344 which SD rats or humans. The CONTAM...
Abstract The European Commission requested EFSA to provide an update of the 2012 Scientific Opinion Panel on Contaminants in Food Chain (CONTAM) risks for animal health related presence ergot alkaloids (EAs) feed. EAs are produced by several fungi Claviceps and Epichloë genera. This focussed 14 C. purpurea (ergocristine, ergotamine, ergocornine, α- β-ergocryptine, ergometrine, ergosine their corresponding 'inine' epimers). Effects observed with from africana (mainly dihydroergosine)...
Abstract EFSA was asked for a scientific opinion on the risks animal and human health related to presence of polychlorinated naphthalenes (PCNs) in feed food. The assessment focused hexaCNs due very limited data other PCN congeners. For feed, 217 analytical results were used estimate dietary exposures food-producing non-food-producing animals; however, risk characterisation could not be performed because none toxicological studies allowed identification reference points. oral repeated dose...
Abstract The European Commission asked EFSA for a risk assessment on small organoarsenic species in food. For monomethylarsonic acid MMA(V), decreased body weight resulting from diarrhoea rats was identified as the critical endpoint and BMDL10 of 18.2 mg MMA(V)/kg (bw) per day (equivalent to 9.7 As/kg bw day) calculated reference point (RP). dimethylarsinic DMA(V), increased incidence urinary bladder tumours endpoint. A 1.1 DMA(V)/kg 0.6 an RP. other species, toxicological data are...
ABSTRACT Expression of the Lactate Dehydrogenase (LDH) genes during various stages spermatogenesis was studied by using a combination Northern blot analyses and in situ hybridization techniques. These studies have indicated that developmentally programmed expression all three functional LDH occurs differentiation germ cells. The LDH/C (ldh-3) gene expressed exclusively meiosis spérmiogenesis, beginning leptotene/zygotene spermatocytes continuing through to elongated spermatids. accompanied...
The small noncoding RNAs (sncRNAs) are considered as post-transcriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting (piRNAs), other sncRNAs generated from nucleolar (snoRNAs), tRNAs, or rRNAs processing may also play important regulatory roles in spermatogenesis. By next-generation sequencing (NGS), we characterized the sncRNA populations detected at three milestone stages differentiation: primordial cells (PGCs), pubertal...
Adenosine deaminases-acting-on-RNA (ADAR) proteins induce adenosine-to-inosine editing in double-stranded RNA molecules. This generates diversity at the post-transcriptional level, and it has been implicated control of cell differentiation development. The microRNA (miRNA) precursors, along with Tudor-SN (Snd1) activity, could lead to elimination selected miRNAs reprogram miRNA activity. Here, we report dynamics precursors their during mouse preimplantation Adar1p110 Snd1 were found be...