A5072544785- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Renal and related cancers
- T-cell and B-cell Immunology
- Renal cell carcinoma treatment
- Single-cell and spatial transcriptomics
- Radioactive element chemistry and processing
- Contact Dermatitis and Allergies
- Renal Transplantation Outcomes and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cancer Genomics and Diagnostics
- Drug-Induced Adverse Reactions
- HIV Research and Treatment
- Cell Image Analysis Techniques
- CAR-T cell therapy research
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Photosynthetic Processes and Mechanisms
- Sepsis Diagnosis and Treatment
- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
Centre Hospitalier Universitaire de Saint-Étienne
2016-2025
Université de Lorraine
2022-2025
Hôpital Nord
1994-2024
Laboratoire de Conception, Optimisation et Modélisation des Systèmes
2022-2024
Centre International de Recherche en Infectiologie
2022-2023
Université Claude Bernard Lyon 1
2016-2023
Centre Hospitalier Universitaire de Clermont-Ferrand
2017-2023
Inserm
2011-2022
Centre National de la Recherche Scientifique
1981-2022
University of Liège
1992-2022
Early hepatocellular carcinoma (HCC) diagnosis is challenging. Moreover, for patients with alpha-fetoprotein (AFP)-negative HCC, this challenge augmented. MicroRNAs (miRs) profiles may serve as potential HCC molecular markers. We aimed to assess plasma homo sapiens-(hsa)-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p-expression levels a panel of biomarkers in chronic hepatitis C virus (CHCV) liver cirrhosis (LC), especially AFP-negative cases, step toward non-protein coding...
Optimal functioning of the immune system is crucial to human health, and nutrition one major exogenous factors modulating different aspects function. Currently, no single marker available predict effect a dietary intervention on To provide further guidance assessment interpretation modulation functions due in general population, International Life Sciences Institute Europe commissioned group experts from academia, government food industry prepare document. A draft this paper was refined at...
Abstract Purpose The authors aim to investigate the altered monocytes subsets distribution in liver cirrhosis (LC) and subsequent hepatocellular carcinoma (HCC) association with expression level of plasma Homo sapiens (has)-miR-21-5p hsa-miR-155-5p. A step toward non-protein coding (nc) RNA precision medicine based on immune perturbation manifested as distribution, top LC HCC. Methods Seventy-nine patients diagnosed chronic hepatitis C virus (CHCV) infection were enrolled current study....
It was shown in children that serum procalcitonin the best marker to use differentiate bacterial from viral meningitis. To evaluate diagnosis of acute and meningitis, we conducted a prospective study including adult patients who were suspected having meningitis admitted an emergency department. Cerebrospinal fluid (CSF) levels measured 105 consecutive patients. The based on clinical findings, gram staining, culture, chemical analysis CSF. Twenty-three had 57 25 did not have Bacteriologic CSF...
Colorectal cancer (CRC) is a major public health issue worldwide, and novel tumor markers may contribute to its efficient management by helping in early detection, prognosis or surveillance of disease. The aim our study was identify new serum biomarkers for CRC, we followed phased biomarker discovery validation process obtain an accurate preliminary assessment potential clinical utility. We compared colonic tumors matched normal tissue from 15 CRC patients, using two-dimensional difference...
BackgroundIodinated and gadolinium-based contrast media (ICM; GBCM) induce immediate hypersensitivity (IH) reactions. Differentiating allergic from non-allergic IH is crucial; allergy contraindicates the culprit agent for life. We studied frequency of among ICM or GBCM reactors.MethodsPatients were recruited in 31 hospitals between 2005 2009. Clinical symptoms, plasma histamine tryptase concentrations skin tests recorded. Allergic was diagnosed by intradermal (IDT) with CM diluted 1:10,...
The immunosuppressive cytokine IL-10 is associated with poor prognosis in colon cancer. Although macrophages are involved antitumor defenses, production of by tumor cells may permit malignant escape to cell-mediated immune defenses. To investigate interactions between and humans, we cultured isolated from patients tested the effect these on several cell lines. Macrophages were pleural effusions malignancy noncancer control patients. We demonstrated that culture supernatants both sources...
The objective of this study was to assess the possibility using urinary exosomal CA9 mRNA as a novel liquid biopsy for molecular diagnosis bladder cancer.A total 168 cancer patients and 90 control subjects were included in study. An isolation kit used isolate exosomes. Transmission electron microscopy (TEM) examine presence Flow cytometry marker CD63. expression level detected by RT-qPCR. diagnostic performance evaluated.TEM confirmed enriched exosomes from patients. indicated strong...
1. The cytotoxicity of metabolites generated from phenytoin, sorbinil and mianserin by human mouse liver microsomes was assessed co‐ incubation with mononuclear leucocytes as target cells. Cytotoxicity determined trypan blue dye exclusion. 2. Phenytoin were metabolised NADPH‐dependent murine microsomal enzymes to cytotoxic metabolites. produced both drugs significantly enhanced the epoxide hydrolase inhibitor trichloropropane oxide (TCPO). No significant observed in presence microsomes. 3....
Vascular alterations are significant events in the pathomechanism of psoriasis. A disorder mechanisms regulating skin angiogenesis and lymphangiogenesis could participate pathogenesis disease.To quantify differences expression growth factors, receptors, coreceptors as well their antagonists uninvolved patients with psoriasis compared nonpsoriatic volunteers.Skin biopsies were collected from involved 13 untreated plaque-type psoriasis, nonlesional at distance lesions 16 healthy volunteers....
Varicella-zoster virus (VZV) gene 63 encodes a protein (IE63) with predicted molecular mass of 30.5 kDa which has amino acid similarities to the immediate-early (IE) 22 (ICP22) herpes simplex type 1. ICP22 is polypeptide synthesized in 1-infected cells, and as case for its VZV counterpart, regulatory functions are unknown. On basis DNA sequence, it been shown that IE63 exhibits hydrophilic acidic properties, suggesting this could play role during infectious cycle. We report article...
The proportion of agalactosyl IgG [Gal(O)] is raised in human rheumatoid arthritis and tuberculosis. We report here that injection pristane into the peritoneal cavities mice on days 0 50, which known to induce plasmacytomas arthritis, also induced a rise Gal(O), correlating with simultaneous level antibody binding 65-kDa heat-shock protein Mycobacterium bovis (hsp65). Arthritis developed those CBA/Igb highest percentage Gal(O). Pretreatment 50 micrograms recombinant mycobacterial hsp65...
To assess the potential role of procalcitonin and tumor necrosis factor-alpha, interleukin-6 interleukin-8, in prognosis patients with sepsis.Prospective study.The emergency unit a teaching hospital.We included 131 sepsis: 15 (12%) septic shock, 20 (15%) severe sepsis 96 (73%) sepsis.Out patients, 112 (85.5%) survived 19 (14.5%) died. These two groups differed regard to simplified acute physiology score II, severity infectious disease underlying disease, bacteremia type microorganisms. The...
A rapid and accurate evaluation of a chemical disinfectant’s bactericidal efficacy is crucial for ensuring effective infection control, preventing the spread pathogens, supporting development new disinfectant formulations. In this study, we report rapid, label-free flow cytometry (FCM) protocol evaluating disinfectants. Five commercial disinfectants (alcohols, oxidizing agents, alkylating agents) were evaluated against type strains recommended by EN 13727+A2 ten clinical strains. The FCM...
Tumor-infiltrating macrophages secrete cytokines, including Fas ligand, tumor necrosis factor-alpha (TNF-alpha), and TNF-related apoptosis-inducing ligand (TRAIL). TRAIL induces apoptosis in cells but not normal cells; however, regulation of its receptors cancer patients is relatively uncharacterized. We investigated whether from produce cultured colon adenocarcinoma involves receptors.Macrophages isolated pleural effusions nine five control with congestive heart failure (whose contained no...
Abstract Purpose: Our main goal was to evaluate a panel of molecular markers for the detection cancer cells in serous effusions and determine their value as an adjunctive reverse transcription-PCR (RT-PCR) test cytologic examination. Experimental Design: One hundred fourteen from 71 patients with tumors 43 benign diseases were subjected RT-PCR expression carcinoembryonic antigen (CEA), epithelial cell adhesion molecule (Ep-CAM), E-cadherin, mammaglobin, mucin 1 (MUC1) isoforms MUC1/REP,...