A5046931659- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Canadian Identity and History
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cutaneous lymphoproliferative disorders research
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders
- Occupational exposure and asthma
- Cutaneous Melanoma Detection and Management
- Linguistic and Sociocultural Studies
- Health, Medicine and Society
- Education, sociology, and vocational training
- Immune Cell Function and Interaction
- Pharmaceutical studies and practices
Université Claude Bernard Lyon 1
2015-2025
Centre National de la Recherche Scientifique
1999-2025
Hôpital Lyon Sud
2016-2025
Centre International de Recherche en Infectiologie
2015-2025
Hospices Civils de Lyon
2016-2025
Inserm
2014-2025
École Normale Supérieure de Lyon
2015-2025
Centre Léon Bérard
1999-2025
Hôpital Edouard Herriot
1996-2019
Institut National de Santé Publique
2016
Abstract Background Chronic spontaneous urticaria ( CSU ) can be debilitating, difficult to treat, and frustrating for patients physicians. Real‐world evidence the burden of is limited. The objective this study was document disease duration, treatment history, activity, as well impact on health‐related quality life HRQ oL) work among with inadequately controlled , describe its humanistic, societal, economic burden. Methods This international observational assessed a cohort 673 adult whose...
The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such include multiple T cell clones antigens. This could obtained using the antigen presenting capacity dendritic cells (DCs) and cross-priming. That is, one load DC with lines any human histocompatibility leukocyte (HLA) type tumor. In this study, we show DCs derived from monocytes loaded killed melanoma prime naive CD45RA+CD27+CD8+ four shared antigens: MAGE-3, gp100,...
Langerhans cells (LCs) represent a subset of immature dendritic (DCs) specifically localized in the epidermis and other mucosal epithelia. As surrounding keratinocytes can produce interleukin (IL)-15, cytokine that utilizes IL-2Rγ chain, we analyzed whether IL-15 could skew monocyte differentiation into LCs. Monocytes cultured for 6 d with granulocyte/macrophage colony-stimulating factor (GM-CSF) differentiate CD1a+HLA-DR+CD14−DCs (IL15-DCs). Agents such as lipopolysaccharide (LPS), tumor...
The aim of this study was to evaluate the semiological value so-called ABCDE criteria in differential diagnosis pigmented tumours. Aside from classical ABCD criteria, an E criterion for 'enlargement' is studied.Records melanoma patients were obtained a database prospectively including treated our department since 1992; 460 files found informative study. A prospective control group established 680 cases benign tumors. All included histopathologically controlled dermatopathology unit. Records...
Drug allergic reactions presenting as maculo-papular exanthema (MPE) are mediated by drug-specific T cells. In this study, the frequency of circulating specific cells was analyzed interferon-gamma (IFN-gamma) enzyme-linked immunospot assay in 22 patients with an MPE to amoxicillin (amox). Amox-specific were detected 20/22 frequencies ranging from 1 : 8000 30 000 leucocytes. No reactivity observed 46 control patients, including 15 immunoglobulin E-mediated allergy amoxicillin, 11 a history...
Abstract Background Oxaliplatin-based regimens induce a potential risk of hypersensitivity reaction (HSR), with incidence varying from 10% to 25% and lack clearly identified factors. The present study aimed assess factors in HSR. Methods All patients treated oxaliplatin the Medical Oncology Department Lyon Sud University Hospital (Hospices Civils de Lyon, France) October 2004 January 2011 were enrolled. Incidence severity HSR analyzed retrospectively clinicopathological covariates tested on...
Abstract Background ASSURE ‐ CSU revealed differences in physician and patient reporting of angioedema. This post hoc analysis was conducted to evaluate the actual rate angioedema study population explore between patients with without Methods international observational assessed 673 inadequately controlled chronic spontaneous urticaria ( ). Physicians abstracted data from medical records, which were compared patient‐reported data. Patients Yes‐angioedema category had reported record a...
Abstract Psychological stress affects the pathophysiology of infectious, inflammatory, and autoimmune diseases. However, mechanisms by which could modulate immune responses in vivo are poorly understood. In this study, we report that application a psychological before immunization exerts an adjuvant effect on dendritic cell (DC), resulting increased primary memory Ag-specific T responses. Acute dramatically enhanced skin delayed-type hypersensitivity reaction to haptens, is mediated CD8+...
Skin lesions in the allergic form of atopic dermatitis (AD) are induced by allergen-specific T cells that infiltrate skin at site allergen exposure. Although Th2-type CD4+ appear to be crucial AD pathophysiology, little is known about contribution CD8+ development inflammation. In present study, we have analyzed respective role and a mouse model allergen-induced AD. sensitized mice, rapidly transiently recruited allergen-exposed initiate inflammatory process leading infiltration with...
BackgroundIodinated and gadolinium-based contrast media (ICM; GBCM) induce immediate hypersensitivity (IH) reactions. Differentiating allergic from non-allergic IH is crucial; allergy contraindicates the culprit agent for life. We studied frequency of among ICM or GBCM reactors.MethodsPatients were recruited in 31 hospitals between 2005 2009. Clinical symptoms, plasma histamine tryptase concentrations skin tests recorded. Allergic was diagnosed by intradermal (IDT) with CM diluted 1:10,...
Abstract Background Interest in the use of omalizumab to treat bullous pemphigoid (BP) event resistance or contraindication conventional therapies is currently based on limited evidence. Objectives To assess effectiveness and safety BP identify predictive factors response treatment. Methods We conducted a French national multicentre retrospective study including patients with confirmed diagnosis treated after failure one several treatment lines. excluded clinically atypical BP, as per...
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare severe adverse drug reaction. Large detailed studies of histopathological features DRESS are sparse suggest an association between keratinocyte damage the severity visceral involvement.To describe dermatopathological in large series their possible clinical disease.A retrospective analysis clinicobiological monocentric cohort patients DRESS.From January 2005 to 2013, 45 were validated as probable or definite cases DRESS....
Abstract Background Chronic spontaneous urticaria (CSU) formerly known as chronic idiopathic (CIU) is a severe and distressing skin condition that remains uncontrolled in approximately one half of patients, despite the use licensed, recommended doses modern, second‐generation H 1 ‐antihistamines. So far, humanistic, societal economic burden CSU/CIU has not been well quantified. Therefore it important to broaden our understanding how impacts society, healthcare systems, by determining disease...
<i>Background:</i> Quinolone hypersensitivity reactions are being more frequently reported. Skin tests in investigations of patients known to not be fully reliable. The provocation test thus remains the gold standard definitive diagnosis allergy, despite risks involved. aim this study was evaluate basophil activation (BATs) immediate-type quinolones. <i>Methods:</i> Thirty-four who presented an hypersensivity reaction less than hour after quinolone administration were...
The links between chronic urticaria, IgE sensitization and allergy have been much discussed but little studied. We investigated in 128 adult urticaria patients during 2006-2008. During a one-day hospitalisation, the answered standardized questionnaire underwent blood serum analysis, physical tests skin prick-tests. to environmental allergens was defined by positivity of at least one prick test and/or elevated levels ≥ 300 Kui/L. considered allergic if: i) high correlation positive clinically...
Abstract Background Thick primary cutaneous melanoma ( PCM ) is associated with older age, male sex, being single, a low educational level, self‐detection and general practice detection, nodular NM acral lentiginous ALM types; are found in the head–neck lower limb locations. Obesity plays direct role on tumour growth, as it has been shown animal models, but its thickness of remains unknown. Objectives We investigated impact obesity invasive . Methods A cross‐sectional study was performed...
Epidermolysis bullosa simplex generalized severe (EBS‐gen sev) is a genetic disorder caused by mutation in the KRT5 or KRT14 genes. Although it usually considered mechanical disease, recent data argue for additional inflammatory mechanisms. To assess inflammation skin of patients with EBS‐gen sev. A first immunohistochemical retrospective study was performed on frozen samples from 17 second multicentre prospective conducted 10 Blister fluid and epidermis were processed immunochemical...