A5073932439- Pregnancy and Medication Impact
- Drug-Induced Hepatotoxicity and Protection
- Pharmaceutical studies and practices
- Drug-Induced Adverse Reactions
- Pharmacovigilance and Adverse Drug Reactions
- Pharmacological Effects and Toxicity Studies
- Blood disorders and treatments
- Pharmaceutical Practices and Patient Outcomes
- Pregnancy and preeclampsia studies
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Immunotoxicology and immune responses
- Peripheral Neuropathies and Disorders
- Animal testing and alternatives
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Lymphocytic Leukemia Research
- Biosimilars and Bioanalytical Methods
- Acute Lymphoblastic Leukemia research
- Epilepsy research and treatment
- Cancer Treatment and Pharmacology
- Contact Dermatitis and Allergies
- Hematological disorders and diagnostics
- Poisoning and overdose treatments
- Blood groups and transfusion
- Hepatitis C virus research
Hospices Civils de Lyon
2016-2025
Prefeitura Municipal de Campos dos Goytacazes
2024
Agence Nationale de Sécurité du Médicament et des Produits de Santé
2003-2024
Gouvernance, Risque, Environnement, Développement
2021-2023
HCL Technologies (India)
2021
Hôpital Lyon Sud
2018-2021
Agence Nationale de la Recherche
2021
Inserm
1990-2019
Université Claude Bernard Lyon 1
1990-2019
Virologie et Pathologies Humaines
2011-2017
To show that germander (Teucrium chamaedrys), an herbal medicine used to facilitate weight loss, may be hepatotoxic and delineate the nature of injury.Retrospective study.Liver units several centers in French Network Pharmacovigilance.Seven patients who developed hepatitis after administration had no other cause liver injury.Clinical examination, function tests, various serologic ultrasonography, histologic study.Hepatitis characterized by jaundice a marked increase serum aminotransferase...
After maternal exposure to mycophenolate in pregnancy a high number of fetal losses and specific pattern birth defects consisting microtia, cleft lip, other anomalies have been reported. However, so far, prospective data on outcome allowing quantitative risk assessment are missing. We report 57 prospectively ascertained pregnancies after therapy with (mycophenolate mofetil or sodium) identified by European Teratology Information Services (ETIS) through their consultation process. The these...
Summary Vitamin K antagonists (VKA) are known to act as teratogens; however, there is still uncertainty about the relative risk for birth defects and most sensitive period. In a multi-centre (n=12), observational, prospective study we compared 666 pregnant women exposed phenprocoumon (n=280), acenocoumarol (n=226), fluindione (n=99), warfarin (n=63) phenindione (n=2) non-exposed control group (n=1,094). Data were collected by institutes collaborating in European Network of Teratology...
Fifteen cases of hepatitis related to a combination amoxycillin and clavulanic acid are reported. Most patients were aged 60 years or more there men than women (sex ratio 4:1). The amoxycillin-clavulanic had been given at doses ranging from 0.5 6 g/day (mean 2 g/day) for seven days 18 days). In 11 cases, the first symptoms appeared one four weeks after stopping treatment. Jaundice was observed in all frequently associated with pruritus. Serum aminotransferase activities increased generally...
Objective High‐dose methotrexate (MTX) exposure during pregnancy is associated with embryopathy. The teratogenic potential of MTX at dosages typically used in the treatment rheumatic diseases remains uncertain. aim this study was to evaluate risk spontaneous abortion, major birth defects, elective termination pregnancy, shortened gestational age delivery, and reduced weight women exposed MTX. Methods Pregnancy outcome taking (≤30 mg/week) either after conception or within 12 weeks before...
This contribution addresses the risk associated with exposure to statins during pregnancy.Multicentre observational prospective controlled study.European Network of Teratology Information Services.Pregnant women who contacted one 11 participating centres, seeking advice about pregnancy, or agents known be nonteratogenic.Pregnancies exposed first trimester were followed up prospectively, and their outcomes compared a matched control group.Rates major birth defects, live births, miscarriages,...
Abstract Background Oxaliplatin-based regimens induce a potential risk of hypersensitivity reaction (HSR), with incidence varying from 10% to 25% and lack clearly identified factors. The present study aimed assess factors in HSR. Methods All patients treated oxaliplatin the Medical Oncology Department Lyon Sud University Hospital (Hospices Civils de Lyon, France) October 2004 January 2011 were enrolled. Incidence severity HSR analyzed retrospectively clinicopathological covariates tested on...
To investigate pregnancy outcomes following maternal use of pregabalin.This multicenter, observational prospective cohort study compared in women exposed to pregabalin with those matched controls (not any medications known be teratogenic or antiepileptic drugs). Teratology Information Services systematically collected data between 2004 and 2013.Data were from 164 pregnancies 656 controls. A significantly higher major birth defect rate the group was observed after exclusion chromosomal...
We described the medication use during pregnancy in French population using Pregnancy Cohort (FPC).The FPC was built with sampling of all pregnant women included Echantillon généraliste des bénéficiaires (EGB), which is a 1/97th representative sample covered by health insurance. The EGB includes anonymized information on socio-demographic and medical characteristics beneficiaries, care services they have received such as diagnoses procedure codes well data filled reimbursed medication; also...
Abstract Purpose The main purpose of this study was to evaluate the risk major malformations after aripiprazole exposure during embryonic period. secondary purposes were assess miscarriage, prematurity, fetal growth retardation and maternal complications describe possible neonatal adverse effects. Methods We conducted a cohort using data prospectively collected by French Pharmacovigilance Centres participating Terappel program Centre de Référence sur les Agents Tératogènes between 2004 2011....
Concerns have been raised about the use of topical retinoids since publication isolated cases characteristic retinoid embryopathy, originally described after oral use. A collaborative study European Network Teratology Information Services was carried out to evaluate rate congenital malformations following first-trimester exposure. population 235 exposed pregnant women compared with 444 controls. No significant differences were observed between groups regard rates spontaneous abortion (odds...
To report the follow-up of continuing pregnancies after first-trimester exposure to mifepristone.Observational prospective study.France.Patients exposed mifepristone during first 12 weeks pregnancy.Women were included in study when they or their doctors asked a French pharmacovigilance centre Paris Teratogen Information Service about risk early pregnancy. Exclusion criteria requests received 22 gestation subsequent elective termination pregnancy without pathological examination fetus. Data...
Aims Metformin is used to treat type 2 diabetes, polycystic ovary syndrome associated infertility, and gestational diabetes. This study aims evaluate the safety of metformin in early pregnancy. Method We evaluated risk major birth defects pregnancy losses a cohort pregnant women exposed during first trimester for different indications relative matched unexposed reference group. Results The was 5.1% (20/392) pregnancies 2.1% (9/431) group [adjusted odds ratio (OR) 1.70; 95% CI 0.70–4.38]....