A5073106442- Antibiotic Resistance in Bacteria
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial biofilms and quorum sensing
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanoparticles: synthesis and applications
- Plant Pathogenic Bacteria Studies
- Gut microbiota and health
- Synthesis and Characterization of Heterocyclic Compounds
- Essential Oils and Antimicrobial Activity
- Bone Tissue Engineering Materials
- Urinary Tract Infections Management
- Bacterial Identification and Susceptibility Testing
- Antimicrobial agents and applications
- Graphene and Nanomaterials Applications
- Inorganic and Organometallic Chemistry
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Biological Evaluation
- Thermal and Kinetic Analysis
- Bacteriophages and microbial interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Infections and bacterial resistance
University of Bucharest
2015-2024
Academy of Romanian Scientists
2021-2023
Carol Davila University of Medicine and Pharmacy
2020
State Phytosanitary Administration
2019
Faculty (United Kingdom)
2013
Institute of Experimental Pharmacology and Toxicology of the Slovak Academy of Sciences
2013
Slovak Academy of Sciences
2013
We report on the genomic characterization of 47 multi-drug resistant, carbapenem resistant and ESBL-producing K. pneumoniae isolates from influent (I) effluent (E) three wastewater treatment plants (WWTPs) Romanian hospital units which are discharging in sampled WWTPs. The whole genome sequences were analyzed for antibiotic resistance genes (ARGs), virulence sequence types (STs) order to compare their distribution C, I E samples. Both clinical environmental samples harbored prevalent widely...
This study presents, for the first-time, results of a on hydrodynamic diameter essential oils (EOs) basil and lavender in water, solutions EOs (B) (L) hydroxyapatite (HAp). The possible influence size nanoparticles was analyzed by Scanning Electron Microscopy (SEM). We also investigated vitro antimicrobial activity plant respectively, against Gram-positive bacteria (methicillin-resistant Staphylococcus aureus1144 (MRSA 1144) S. aureus 1426) Gram-negative (Escherichia coli ATCC 25922...
In this paper we describe the transmission of a multi-drug resistant Klebsiella pneumoniae ST101 clone from hospital to wastewater and its persistence after chlorine treatment. Water samples influents effluents sewage tank an infectious diseases clinical strains collected intra-hospital infections, during period 10 days prior sampling were analyzed. Antibiotic K. wastewaters recovered on selective media. Based antibiotic susceptibility profiles PCR analyses resistance (AR) genetic...
The aim of this study was the evaluation nanoparticles (Ag:HAp‐NPs) for their antibacterial and antifungal activity. Resistance to antimicrobial agents by pathogenic bacteria has emerged in recent years as a major public health problem worldwide. In paper, we report comparison activity low concentrations silver‐doped hydroxyapatite nanoparticles. nanocrystalline powder synthesized at 100°C deionised water. as‐prepared Ag:Hap were characterized X‐ray diffraction (XRD), transmission electron...
A number of acylthioureas, 2-((4-methylphenoxy)methyl)-N-(aryl-carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro-phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluorophenyl, 2,4,5-trifluoro-phenyl, 2,4,6-trifluorophenyl) have been synthesized, characterized by elemental analysis, IR and NMR spectroscopy tested for their interaction with bacterial cells in...
The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion 2,2'-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature [Mn₃(2,2'-bipy)₂(C₃H₃O₂)₆] (1), meanwhile with general formula [M(2,2'-bipy)(C₃H₃O₂)₂(H₂O)x]∙yH₂O ((2) M: Ni, x = 1, y 0; (3) Cu, (4) Zn, 0, 1; 2,2'-bipy: 2,2'-bipyridine; C₃H₃O₂: anion) were shown to be mononuclear. lowest minimum inhibitory concentration (MIC)...
Silver-zinc oxide nanoparticles (AgZnO NPs) were chemically synthesized by the deposition of Ag NPs on surface ZnO using silver nitrate, three types anionic polyelectrolytes and citric acid as reagents. The Wavelength Dispersive X-ray Fluorescence (WDXRF) spectrometry AgZnO revealed 0.41–0.69 wt% Ag, balance ZnO. existence with hexagonal wurtzite structure was highlighted Diffraction (XRD) analysis, scanning electron microscopy (SEM), Ultraviolet–Visible (UV–Vis) spectroscopy. diffuse...
Antibiotic resistance has become a serious global health threat. Wastewater treatment plants may unintentional collection points for bacteria resistant to antimicrobials. Little is known about the transmission of antibiotic from wastewater humans, most importantly plant workers and residents living in vicinity. We aim deliver precise information methods used AWARE (Antibiotic Resistance Wastewater: Transmission Risks Employees Residents around Treatment Plants) study. Within study, we...
Romania is one of the European countries reporting very high antimicrobial resistance (AMR) rates and consumption antimicrobials. We aimed to characterize AMR profiles clonality 304 multi-drug resistant (MDR) Acinetobacter baumannii (Ab) Pseudomonas aeruginosa (Pa) strains isolated during two consecutive years (2018 2019) from hospital settings, collecting sewage tanks receiving wastewater treatment plants (WWTPs) located in main geographical regions Romania.The were on chromogenic media...
A current major healthcare problem is represented by antibiotic resistance, mainly due to multidrug resistant (MDR) Gram negative bacilli (GNB), because of their extended spread both in hospital facilities and the community's environment. The aim this study was investigate virulence traits Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa MDR, XDR, PDR strains isolated from various hospitalized patients. These GNB were investigated for presence soluble factors (VF), such...
Nosocomial infections represent a major threat within healthcare systems worldwide, underscoring the critical need for materials with antimicrobial properties. This study presents development of polyurethane foam embedded silver nanoparticles (PUF/AgNPs) using rapid, eco-friendly, in situ radiochemical synthesis method. The nanocomposites were characterized by UV–vis and FTIR spectroscopy, scanning electron microscopy coupled energy dispersive X-ray technique (SEM/EDX), differential...
Urinary tract infections (UTIs) caused by Uropathogenic Escherichia coli (UPEC) are among the most common worldwide, including Romania. To best of our knowledge, this is first study performed on a significant number community-acquired (CA) UPEC strains isolated from Romanian outpatients, aiming to evaluate and establish potential correlations phylogenetic groups (PG), resistance profiles, virulence factors (VF) genes CA-UPEC isolates.The present was total 787 nonrepetitive isolates...
In an effort to improve the antimicrobial activity of norfloxacin, a series hybrid norfloxacin-thiazolidinedione molecules were synthesized and screened for their direct anti-biofilm properties. The new hybrids intended have binding mode DNA gyrase, that will allow more potent antibacterial effect, against current quinolone-resistant bacterial strains. Moreover, thiazolidinedione moiety aimed include additional anti-pathogenicity by preventing biofilm formation. resulting compounds...
Composite hydrogels based on pullulan (HP) and poly(vinyl alcohol) (PVA) were both prepared by simple chemical crosslinking with sodium trimethaphosphate (STMP) or dual (simultaneously STMP physical freeze-thaw technique). The resulting cryogels designed for tissue engineering applications. PVA, two different molecular weights (47,000 125,000 g/mol; PVA47 PVA125, respectively), as well P/PVA weight ratios tested. physico-chemical characterization of the was performed FTIR spectroscopy...
The increasing threat of antimicrobial resistance to all currently available therapeutic agents has urged the development novel antimicrobials. In this context, a series new benzoylthiourea derivatives substituted with one or more fluorine atoms and trifluoromethyl group have been tested, synthesized, characterized by IR, NMR, CHNS crystal X-ray diffraction. molecular docking provided information regarding binding affinity orientation compounds
In a drug-repurposing-driven approach for speeding up the development of novel antimicrobial agents, this paper presents first time in scientific literature synthesis, physico-chemical characterization, silico analysis, activity against bacterial and fungal strains planktonic biofilm growth state, as well vitro cytotoxicity some new 6,11-dihydrodibenz[b,e]oxepin-11(6H)one O-(arylcarbamoyl)oximes. The structures intermediary final substances (compounds 7a-j) were confirmed by 1H-NMR, 13C-NMR...
A rapid and accurate evaluation of a chemical disinfectant’s bactericidal efficacy is crucial for ensuring effective infection control, preventing the spread pathogens, supporting development new disinfectant formulations. In this study, we report rapid, label-free flow cytometry (FCM) protocol evaluating disinfectants. Five commercial disinfectants (alcohols, oxidizing agents, alkylating agents) were evaluated against type strains recommended by EN 13727+A2 ten clinical strains. The FCM...
This article offers a review regarding current approaches in bioactive dressings design, the components as well experimental models used to assess their efficiency. Wound come variety of materials including natural polymers and synthetic manufactured into various forms, such foams, films, hydrocolloids, hydrogels, sponges, membranes, skin substitutes, electrospun micro nanofibers. Until now there is no available dressing able meet criteria for fast adequate wound healing. The material may...