A5035743675- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
- Fungal Biology and Applications
- Antifungal resistance and susceptibility
- Building materials and conservation
- Essential Oils and Antimicrobial Activity
- Fungal and yeast genetics research
- Gut microbiota and health
- Nanoparticles: synthesis and applications
- Orthopedic Infections and Treatments
- Anorectal Disease Treatments and Outcomes
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Vibrio bacteria research studies
- Healthcare and Environmental Waste Management
- SARS-CoV-2 detection and testing
- Yeasts and Rust Fungi Studies
- Fungal Infections and Studies
- Colorectal and Anal Carcinomas
- Wound Healing and Treatments
- Fermentation and Sensory Analysis
University of Bucharest
2022-2025
Academy of Romanian Scientists
2023
Melissa officinalis is an important medicinal plant that used and studied intensively due to its numerous pharmacological effects. This has active compounds with biomedical potential; some are volatile, while others sensitive heat or oxygen. Therefore, increase stability prolong biological activities, the natural extract can be loaded into various nanostructured systems. In this study, different loading systems were obtained from mesoporous silica, like Mobile Composition of Matter family...
Romania is one of the European countries reporting very high antimicrobial resistance (AMR) rates and consumption antimicrobials. We aimed to characterize AMR profiles clonality 304 multi-drug resistant (MDR) Acinetobacter baumannii (Ab) Pseudomonas aeruginosa (Pa) strains isolated during two consecutive years (2018 2019) from hospital settings, collecting sewage tanks receiving wastewater treatment plants (WWTPs) located in main geographical regions Romania.The were on chromogenic media...
A current major healthcare problem is represented by antibiotic resistance, mainly due to multidrug resistant (MDR) Gram negative bacilli (GNB), because of their extended spread both in hospital facilities and the community's environment. The aim this study was investigate virulence traits Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa MDR, XDR, PDR strains isolated from various hospitalized patients. These GNB were investigated for presence soluble factors (VF), such...
Background/Objectives: This study aims to characterize antibiotic resistance (AR) and virulence markers in Salmonella spp. isolated from Romanian outpatients’ stool samples. Methods: In 2019, community-acquired strains were collected identified using MALDI-TOF mass spectrometry, susceptibility profiles have been determined with the MicroScan system, soluble factors evaluated specific culture media, while biofilm formation was quantified 96-well plates. Molecular analysis targeted genes for...
This paper describes the synthesis and evaluation of samarium-doped 45S5 bioactive glass in various ratios. The samples were prepared using sol–gel method subjected to a heat treatment at 700 °C normal atmosphere. obtained analyzed by thermogravimetric analysis (TGA) before after assess their thermal stability compositional changes. bioactivity was tested vitro immersion simulated body fluid (SBF) 36.5 ± 0.5 (normal human temperature) pH 7.4 (the blood plasma), for several time periods....
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition, primarily affecting young individuals, with significant impact on their quality of life due to recurrent, painful nodules, abscesses, and oozing sinus tracts, intertriginous areas. The pathogenesis HS multifactorial, involving complex interplay between genetic predisposition, immune dysregulation, microbial, environmental factors. While it known that cutaneous gut microbiome contribute innate dysregulation in HS, precise...
Nosocomial fungal infections caused by Candida auris pose a threat to public health due their increased resistance common antifungal drugs. Four thiourea derivatives of 2-thiophenecarboxylic acid were evaluated for and antioxidant activity. The activity the compounds was tested against strains C. isolated from hospital in Romania. With notable inhibitory effect on biofilm growth microbial adherence, ortho-methylated derivative (SB2) showed highest Furthermore, emphasizing impact structural...
Acinetobacter baumannii, a notorious opportunistic pathogen, presents formidable challenge in both clinical and environmental fields due to its resilience ability acquire resistance. This study undertook comprehensive analysis of 183 A. baumannii isolates collected between 2019 2022 from intra-hospital infections (IHI), hospital sewages (Hs), wastewater treatment plants (WWTP), adjacent river waters two Southern cities, focusing on their resistome, virulome, mobilome through isolation...
Introduction Chronic venous ulcers of the lower limbs develop in context advanced disease and have a significant impact on patient’s quality life, being associated with depression worrisome suicide rates, as well an economic burden caused by increased medical care costs high epidemiological risks healthcare infections emergence strains resistant to multiple classes antibiotics and/ or antiseptics. Although numerous studies investigated composition chronic wounds microbiome, either...
This study aimed to determine, at the phenotypic and molecular levels, resistance virulence markers in
This study aims to demonstrate the effectiveness of silver nanoparticles (Ag NPs) on multidrug-resistant (MDR) Acinetobacter baumannii (AB) strains isolated from clinical and aquatic environment. Three types Ag NPs were investigated for their antimicrobial, antibiofilm, antivirulence properties a total number 132 AB in same temporal sequence intra-hospital infections (IHIs), wastewater (WW), surface water (SW) samples between 2019 2022 different Romanian locations characterized at phenotypic...
Introduction: Biodeterioration is a big challenge for the preservation of cultural heritage objects and community’s safety, fostering search novel methods effective in removing microbial biofilms subsequent biodeterioration. In this context, nanoparticles (NPs) are considered an interesting alternative, based on their unique physico-chemical biological properties. Methods: The present study aimed to evaluate antimicrobial efficiency Ag, Au, Cu, ZnO NPs against significant number filamentous...
Biodeterioration of cultural heritage is caused by different organisms capable inducing complex alteration processes. The present study aimed to evaluate the efficiency Rosmarinus officinalis hydro-alcoholic extract inhibit growth deteriogenic microbial strains. For this, physico-chemical characterization vegetal UHPLC–MS/MS, its antimicrobial and antibiofilm activity on a representative number biodeteriogenic strains, as well antioxidant determined DPPH, CUPRAC, FRAP, TEAC methods, were...
Urban wastewater treatment plants harbor a large collection of antibiotic resistant enteric bacteria. It is therefore reasonable to hypothesize that workers at such would possess more diverse set bacteria, compared the general population. To address this hypothesis, we have fecal microbiome and resistome 87 (WWTPs) from Romania Netherlands those control individuals, using shotgun metagenomics. Controlling for potential confounders, neither total resistance gene (ARG) abundance, nor overall...
Background: This study provides a comprehensive analysis of Acinetobacter baumannii in aquatic environments and fish microbiota by integrating culture-dependent methods, 16S metagenomics, antibiotic resistance profiling. Methods: A total 83 A. isolates were recovered using methods from intra-hospital infections (IHI), wastewater (WW) surface water (SW) samples two southern Romanian cities august 2022. The susceptibility was screened disc diffusion, microdilution, PCR Whole Genome Sequencing...
This study provides a comprehensive analysis of
Epiphytic yeasts represent an important source for the development of novel strategies aiming to combat food microbial contamination. The present study deals with characterization nine yeast strains belonging Starmerella, Candida, Metschinikowia, Lachancea, Kodamaea and Pichia genera, isolated from surface plants Botanical Garden “Dimitrie Brandza” (Bucharest, Romania) use as antimicrobial probiotic agents. tests involved determination safe status, cell growth under stress conditions,...
The Gram-negative bacilli (GNB) tend to dominate the infectious pathology, often due multidrug-resistant (MDR) strains and evolving with severe, complicated, difficult-to-treat clinical forms. This study aimed investigate by phenotypic genotypic assays a representative set of carbapenem-resistant GNB evaluate their contribution appropriate epidemiological surveillance therapy associated infections. A number 70 Enterobacterales MDR bacterial were consecutively isolated from patients different...
Introduction: Given the high mobility of antibiotic resistance genes and their propensity for transmission among human, animal, environmental reservoirs, managing risks associated with is a challenging goal. The Acinetobacter species are most relevant bacteria clinical significance special abilities to acquire mechanisms survive in diverse conditions. A particular interest A. baumannii strains association chronic nosocomial infections, such as pneumonia, urinary tract soft tissue or...
One of the most important essential pillars in fight against antibiotic resistance is to optimize treatment by developing and optimizing appropriate methods establish susceptibility profiles a specific microbial strain. Moreover, this will contribute suveillance limitation antimicrobial transmission spread. Therefore, it also imperative harmonize different approaches techniques perform suitable tests microbiology laboratories achieve precise, reproducible, comparable results. However,...