A5066002729- Agricultural safety and regulations
- Effects and risks of endocrine disrupting chemicals
- Neonatal Health and Biochemistry
- Phytochemicals and Antioxidant Activities
- Drug Transport and Resistance Mechanisms
- Carcinogens and Genotoxicity Assessment
- Heme Oxygenase-1 and Carbon Monoxide
- Metabolism and Genetic Disorders
- Biochemical Analysis and Sensing Techniques
- Consumer Attitudes and Food Labeling
- Pesticide Residue Analysis and Safety
- Metabolomics and Mass Spectrometry Studies
- Natural Antidiabetic Agents Studies
- Antioxidant Activity and Oxidative Stress
- Diet, Metabolism, and Disease
- Free Radicals and Antioxidants
- Occupational exposure and asthma
- Genetically Modified Organisms Research
- Pharmaceutical studies and practices
- Horticultural and Viticultural Research
- Hemoglobin structure and function
- Trace Elements in Health
- Liver Disease Diagnosis and Treatment
- Fermentation and Sensory Analysis
- Vitamin K Research Studies
University of Trieste
2015-2025
Dalhousie University
2019
National University of Rosario
2007
Fondazione Edmund Mach
2005
University of Padua
1994-2004
Reaction of isolated mitochondria with a variety agents that lead to oxidation or cross-linking sulfhydryl groups leads an increased "open" probability the permeability transition pore, cyclosporin A-sensitive channel.We have investigated mechanism by which pore is induced menadione, diamide, arsenite, and tert-butylhydroperoxide.We find these inducers increase ppening shifting its gating potential higher values.Furthermore, shift was prevented treatment N-ethylmaleimide dithiothreitol.At...
The present opinion deals with an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by Panel to be reliable, including data obtained TiO
The ability of anthocyanins to permeate the gastric mucosa can be suggested as a possible explanation fast kinetics plasma appearance in rats and humans. This paper presents an vivo experiment aimed prove involvement stomach absorption grape rats. required analytical selectivity sensitivity was achieved by high‐performance liquid chromatography, diode array detection mass spectrometry. Malvidin 3‐glucoside appeared both portal systemic after only 6 min. average concentrations measured were...
Anthocyanins represent the main flavonoid pigments in red grape and wine, berries, many other fruits vegetables are widespread human diet. After ingestion, these complex, hydrophilic compounds quickly appear as intact molecules plasma. This study investigated their presence brain of anesthetized rats that received 8 mg/kg body weight a pure anthocyanin mixture extracted from Vitis vinifera grapes. The was maintained stomach for 10 min. this time, anthocyanins were detected by HPLC-DAD-MS not...
Different polyphenol compounds are ingested when consuming a serving of fruits rich in polyphenols, spanning from one-phenol hydroxybenzoic acid to more complex polymeric compounds. Only minor quantity the polyphenols (5-10%) is absorbed. The remainder reaches colon and extensively metabolized by gut microbiota low-molecular weight metabolites. Their subsequent tissue distribution still undefined, although these microbial metabolites currently believed play role human health disease states....
Abstract Bilirubin is a standard serum biomarker of liver function. Inexplicably, it inversely correlated with cardiovascular disease risk. Given the role endothelial dysfunction in originating diseases, direct analysis bilirubin vascular endothelium would shed light on these relationships. Hence, we used high-performance liquid chromatography coupled thermal lens spectrometric detection and diode array for determination endogenous cellular IXα-bilirubin. To confirm isomer IXα-bilirubin,...
Abstract Anthocyanins exert neuroprotection in various vitro and vivo experimental models. However, no details regarding their brain-related pharmacokinetics are so far available to support claims about direct neuronal bioactivity as well design proper formulations of anthocyanin-based products. To gather this missing piece knowledge, we intravenously administered a bolus 668 nmol cyanidin 3-glucoside (C3G) anaesthetized Wistar rats shortly after (15 s 20 min) collected blood, brain, liver,...
A series of water-soluble fullerene C60 derivatives has been investigated for their cytotoxic and hemolytic properties, with the aim to correlate structure toxicity. We observed that cationic chains induce significant toxicity while presence neutral or anionic moieties did not produce any response in our model. validation these experimental observations performed by theoretical studies which hydrophilic hydrophobic surface areas were correlated quantitatively properties.
This study sought to investigate the possible mechanisms for use of phenolic extracts from grapefruit peels in management/prevention cardiovascular complications. The effects on key enzymes relevant diseases [3-hydroxy-methyl-3-glutaryl coenzyme A reductase (HMG-CoA reductase) and angiotensin-I converting enzyme (ACE)], cellular antioxidant activity human endothelial cells (EA.Hy 926) radicals [1,1-diphenyl-2 picrylhydrazyl (DPPH) 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)...
Abstract Sulfur dioxide–sulfites (E 220–228) were re-evaluated in 2016, resulting the setting of a temporary ADI 0.7 mg SO2 equivalents/kg bw per day. Following European Commission call for data, present follow-up opinion assesses data provided by interested business operators (IBOs) and additional evidence identified publicly available literature. No new biological or toxicological addressing gaps described re-evaluation submitted IBOs. Taking into account from literature search, Panel...
Uveal melanoma (UM) is an ocular cancer, with propensity for lethal liver metastases. When metastatic UM (MUM) occurs, as few 8% of patients survive beyond two years. Efficacious treatments MUM are urgently needed. 1,4-dihydroxy quininib, a cysteinyl leukotriene receptor 1 (CysLT
Abstract Anthocyanins are among the most common flavonoids in human diet. In spite of their very low bioavailability, anthocyanins indicated as active preventing progress cardiovascular and neurodegenerative diseases, obesity, inflammation, cancer. Any piece knowledge concerning absorption, tissue distribution, metabolism, excretion dietary is expected to help understanding apparent paradox between concentrations cells bioactivity. The aim this work was investigate renal uptake underlying...
AimsIngestion of flavonoid-rich beverages acutely affects endothelial function, causing vasodilation. This effect might be dependent on flavonoid transport into the endothelium. We investigated uptake vascular cells and whether this was mediated by bilitranslocase (TC 2.A.65.1.1), a bilirubin-specific membrane carrier that also transports various dietary flavonoids.
To asses the hypothesis that anthocyanins are rapidly taken up from blood into tissues, where they accumulate to their bioactivity threshold, an intravenous dose of cyanidin 3-glucoside (1) was administered anaesthetized rats. Cyanidin and its metabolites were analyzed in plasma, kidneys, liver, urine, bile, using last-generation mass spectrometry. Compound 1 found disappear plasma (t/2 = 0.36 min). As soon as 15 s after administration, both methylation product, peonidin (2), detected liver....