A5014591678- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- Nanofabrication and Lithography Techniques
- SARS-CoV-2 and COVID-19 Research
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Immunotherapy and Immune Responses
- Polymer Surface Interaction Studies
- Mesoporous Materials and Catalysis
- 3D Printing in Biomedical Research
- Genomics and Chromatin Dynamics
- Blood properties and coagulation
- SARS-CoV-2 detection and testing
- Advanced biosensing and bioanalysis techniques
- Groundwater and Isotope Geochemistry
- Protein Interaction Studies and Fluorescence Analysis
- Advanced ceramic materials synthesis
- Antimicrobial Peptides and Activities
- Dental materials and restorations
- Polymer Nanocomposite Synthesis and Irradiation
- Microbial Metabolic Engineering and Bioproduction
- Advanced Drug Delivery Systems
- Nanocluster Synthesis and Applications
University College Dublin
2017-2022
San Antonio College
2022
Museu da Amazonia
2022
Centro de Estudos e Pesquisas em Educação, Cultura e Ação Comunitária
2022
Universidade Federal de Santa Catarina
2015-2021
Brazilian Center for Research in Energy and Materials
2020-2021
Brazilian Synchrotron Light Laboratory
2020-2021
Universidade Estadual de Campinas (UNICAMP)
2015
Universidade Estadual de Maringá
2015
Pontifícia Universidade Católica de Campinas
2015
The transport and the delivery of drugs through nanocarriers is a great challenge pharmacology. Since production liposomes to reduce toxicity doxorubicin in patients, plethora nanomaterials have been produced characterized. Although it widely known that elementary properties influence their vivo kinetics, such interaction often poorly investigated many preclinical studies. present study aims evaluate actual effect size shape on biodistribution set gold nanoparticles (GNPs) after intravenous...
The range of possible nanostructures is so large and continuously growing, that collating unifying the knowledge connected to them, including their biological activity, a major challenge. Here we discuss concept based on connection microscopic features nanomaterials impacts. We also consider what would be necessary identify control interactions, make them resemble each other in context.
Abstract The interaction of promising nanoparticles with red blood cells (RBCs) is a critical point to be addressed in nanomedicine and nanotoxicology, the hemolytic assay classical common test used evaluate such interactions consequent nanoparticle toxicity. In addition, protein corona an emergent concept bionanoscience associated manifestation energetically driven protein–nanoparticle interactions, great impact on nanomaterial toxicity assessment. convergence these two concepts, we...
The outreach of nanoparticle-based medical treatments has been severely hampered due to the imbalance between efforts in designing extremely complex materials and general lack studies devoted understanding their colloidal stability biological environments. Over years, scientific community neglected relevance related nanoparticles' state, which consequently resulted very poor bench-to-clinic translation. In this work, we show how mesoporous silica nanoparticles (MSNs, one most promising...
Described here is an anticancer material based on colloidal mesoporous silica nanoparticles (MSNs) functionalized with doxorubicin (DOX), and incorporated into Pluronic F127 hydrogels for prolonged release, a potential therapeutic application prostate cancer treatment. The MSNs have spherical morphology, size of about 60 nm, surface area 970 cm2 g–1 average pore width 2.0 nm. A high stability the in physiological medium used vivo administration (NaCl 0.9% w/v) could be attained presence...
We report here that the surface topography of colloidal mesoporous silica nanoparticles (MSNs) plays a key role on their bionano-interactions by driving adsorption biomolecules nanoparticle through matching mechanism between cavities characteristics and stereochemistry. This conclusion was drawn analyzing biophysicochemical properties MSNs in presence single biomolecules, such as alginate or bovine serum albumin (BSA), well dispersed complex biofluid, human blood plasma. When phosphate...
Since it is now possible to make, in a controlled fashion, an almost unlimited variety of nanostructure shapes, increasing interest understand the forms biological control that nanoscale shape allows. However, priori rational investigation such vast universe shapes appears present intractable fundamental and practical challenges. This has limited useful systematic their interactions development innovative shape-dependent therapies. Here, we introduce concept biologically relevant inductive...
Zwitterionic molecules are known to resist nonspecific protein adsorption and have been proposed as an alternative the widely used polyethylene glycol. Recently, zwitterionic-like nanoparticles were created from coimmobilization of positive negative ligands, resulting in surfaces that also prevent corona formation while keeping available sites for bioconjugation. However, it is unclear if they able keep their original properties when immersed biological environments retaining a toxicity-free...
Abstract The modification of the surface characteristics after treatment with plasma in polymeric materials, such as aging phenomenon, calls attention research area nonthermal technology. In this work, a direct dielectric‐barrier discharge was used on surfaces ultrafiltration membranes. measurements contact angle water, attenuated total reflectance accessory, zeta potential, atomic force microscopy and scanning electron microscopy‐MEV were performed to verify changes understand occurrence...
We describe here a drug depot hydrogel system comprising sildenafil (Viagra®) incorporated in mesoporous silica nanoparticles (60 nm) and conjugated with thermosensitive poloxamer, which presents high efficiency against prostate cancer.
Recent observations suggest a role for complex nanoscale particulate shape in the regulation of specific immune-related cellular and vivo processes. We suspect that recognition nanostructure architecture could involve nonmolecular inputs, including transduction spatially resolved stresses induced by shape. Here, we report shape-dependent control epigenome. Interpretation ChIP-Seq sequencing suggests differential marking H3K27me3 may be linked to sensory synapse-recognition forces The raise...
Simple surface modification of nano-hydroxyapatite, through acid-basic reactions, allows expanding the properties this material. Introduction organic groups such as hydrophobic alkyl chains, carboxylic acid, and amide or amine basic on hydroxyapatite systematically change polarity, area, reactivity without modifying its phase. Physical chemical new derivative particles were analyzed. The biocompatibility modified Nano-Hap Raw 264.7 cells was also assessed.
Alguns mananciais subterrâneos apresentam contrações de fluoretos acima do limite permitido pelas legislações ambientais e em concentrações elevadas podem ser classificados como um contaminante, provocando graves problemas saúde. O processo adsorção com carvão ativado tem sido amplamente estudado para desfluoretação das águas. Objetivo presente trabalho foi avaliar o remoção fluoreto águas, Na caracterização textural adsorvente foram analisados os parâmetros: área superficial específica...
One of the major problems in cancer therapies is high occurrence side effects intrinsic anticancer drugs. Doxorrubicin a conventional molecule used to treat wide range cancer, such as breast, ovarian and prostate. However, its use associated with number like multidrug resistance cardiotoxicity. The association nanomaterials has been considered past decade overcome toxicity these In this context, mesoporous silica nanoparticles are great candidates be carriers once they very biocompatible....
Because of high occurrence side effects conventional anticancer drugs, new therapies have been widely studied, such as the use non-usual molecules and association with nanomaterials.In this context, sildenafil is a molecule that has lately considered co-adjuvant in cancer therapy because it inhibits an enzyme potential role tumor progression, phosphodiesterase-5.Taking into account combination nanoparticles sildenafil, we produced systems based on mesoporous silica nanoparticles, Pluronic...