A5087391721- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Pesticide and Herbicide Environmental Studies
- Research on Leishmaniasis Studies
- Chemistry and Chemical Engineering
- MXene and MAX Phase Materials
- Graphene research and applications
- Advanced Nanomaterials in Catalysis
- Trypanosoma species research and implications
- Microplastics and Plastic Pollution
- Environmental Chemistry and Analysis
- Historical and socio-economic studies of Spain and related regions
- Pigment Synthesis and Properties
- E-Government and Public Services
- COVID-19 and healthcare impacts
- Human Rights and Immigration
- Pesticide Exposure and Toxicity
- Galician and Iberian cultural studies
- Advanced oxidation water treatment
- Dye analysis and toxicity
- Nanoplatforms for cancer theranostics
- Carcinogens and Genotoxicity Assessment
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024
University of Manchester
2019-2023
Manchester Academic Health Science Centre
2022-2023
Henry Royce Institute
2022-2023
Hospital Universitário da Universidade de São Paulo
2023
China Classification Society
2022
Universidade Estadual de Campinas (UNICAMP)
2013-2019
Universidad Nacional de Loja
2017
Flint Institute Of Arts
2012
Universidade Estadual Paulista (Unesp)
2012
The role of dietary antioxidants in human health remains controversial. Fruits and vegetables the diet are associated with lower rates chronic disease, this is often attributed to their content antioxidants, a resulting protection against oxidative stress. However, large-scale trials antioxidant supplements have shown, if anything, an increase mortality. We investigated biological properties β-cryptoxanthin, common carotenoid, cell culture model systems, using comet assay measure DNA damage....
In this work, we developed and screened the potential antitumor activity of a nanocarrier based on graphene oxide (GO) folic acid (FA) for delivery chemotherapy drugs. GO was synthesized by graphite exfoliation process. FA linked to PEG (4,7,10-trioxa-1,13-tridecanediamine) form FA–PEG, followed coupling surface. Camptothecin (CPT) further adsorbed use as drug model in study. The synthesis intermediate FA–PEG molecule formation GO–FA were confirmed basic state-of-the-art characterization...
Graphene oxide (GO) is a highly oxidized graphene form with oxygen functional groups on its surface. GO an excellent platform to support and stabilize silver nanoparticles (AgNP), which gives rise the oxide-silver nanoparticle (GOAg) nanocomposite. Understanding how this nanocomposite interacts cells toxicological challenge of great importance for future biomedical applications, macrophage can provide information concerning biocompatibility these nanomaterials. The cytotoxicity GOAg...
Graphene-related materials (GRMs) are subject to intensive investigations and considerable progress has been made in recent years terms of safety assessment. However, limited information is available concerning the hazard potential GRM-containing products such as graphene-reinforced composites. In present study, we conducted a comprehensive investigation biological effects particles released through an abrasion process from reduced graphene oxide (rGO)-reinforced composites polyamide 6...
COVID-19 lung sequelae can impact the course of patient lives. We investigated evolution pulmonary abnormalities in post-COVID-19 patients 18-24 months after hospital discharge.
Graphene-based materials (GBMs) have promising applications in various sectors, including pulmonary nanomedicine. Nevertheless, the influence of GBM physicochemical characteristics on their fate and impact lung has not been thoroughly addressed. To fill this gap, biological response, distribution, bio-persistence four different GBMs mouse lungs up to 28 days after single oropharyngeal aspiration are investigated. None GBMs, varying size (large versus small) carbon oxygen ratio as well...
Abstract The interaction of promising nanoparticles with red blood cells (RBCs) is a critical point to be addressed in nanomedicine and nanotoxicology, the hemolytic assay classical common test used evaluate such interactions consequent nanoparticle toxicity. In addition, protein corona an emergent concept bionanoscience associated manifestation energetically driven protein–nanoparticle interactions, great impact on nanomaterial toxicity assessment. convergence these two concepts, we...
Graphene has drawn a lot of interest in the material community due to unique physicochemical properties. Owing high surface area volume ratio and free oxygen groups, oxidized derivative, graphene oxide (GO) promising potential as drug delivery system. Here, lung tolerability two distinct GO varying lateral dimensions is investigated, reveal most suitable candidate platform for pulmonary delivery. Following repeated chronic exposure mice sheet suspensions, innate adaptive immune responses are...
A key aspect of any new material safety assessment is the evaluation their in vivo genotoxicity. Graphene oxide (GO) has been studied for many promising applications, but there are remaining concerns about its profile, especially after inhalation. Herein we tested whether GO lateral dimension, comparing micrometric (LGO) and nanometric (USGO) sheets, a role formation DNA double strand breaks mouse lungs. We used spatial resolution differential cell type analysis to measure damages both...
Boron nitride (BN) nanomaterials have drawn a lot of interest in the material science community. However, extensive research is still needed to thoroughly analyze their safety profiles. Herein, we investigated pulmonary impact and clearance two-dimensional hexagonal boron (h-BN) nanosheets nanotubes (BNNTs) mice. Animals were exposed by single oropharyngeal aspiration h-BN or BNNTs. On days 1, 7, 28, bronchoalveolar lavage (BAL) fluids lungs collected. one hand, adverse effects on evaluated...
Graphene oxide (GO) and silver nanoparticles (AgNPs) can be formed into a hybrid nanomaterial, known as GOAg nanocomposite, which presents high antibacterial activity. The successful translation of this nanomaterial medical use depends on critical information about its toxicological profile. In keeping with Safe-by-design approach, we evaluated the immunotoxicity using J774 primary murine macrophages. interaction between macrophages was investigated scanning electron microscope (SEM)....
Leishmanioses are neglected diseases and the parasite Leishmania survives proliferates within mononuclear phagocytes, particularly macrophages. In vitro studies of immunology cell biology leishmaniosis performed in murine peritoneum bone marrow macrophages immortalized lines despite normal injured tissue-specific heterogeneity this work, we established an ex vivo methodology to culture lesional cells from BALB/c mice infected with amazonensis. The were successfully isolated footpad skin...
The surfactants are amphipathic molecules that promote the reduction of surface tension water. objectives were to estimate LC(I)50;96h; determine assessment risk;to assess water quality and intoxication signs during tests with Agral®, Aterbane®BR, Ag-Bem®, Energic®, Fixade®e Gotafix® for guaru (Phalloceros caudimaculatus). animals exposed a control treatment in completely randomized design three replicates. To characterize risk used data estimated environmental concentration LC(I)50;96 hours...
Efluentes de indústrias farmacêuticas veterinárias, que formulam medicamentos, são gerados principalmente durante a lavagem dos equipamentos. O objetivo desse trabalho foi avaliar toxicidade aguda para Daphnia similis e crônica Ceriodaphnia dubia, efluentes brutos tratados por uma indústria farmacêutica veterinária. sistema tratamento usado é composto etapa químico (coagulação-sedimentação forçada) seguida do biológico aeróbio (processo lodos ativados). Foram realizadas 5 campanhas...
Background: COVID-19 lung sequelae can impact the course of patient lives. We investigate evolution pulmonary abnormalities in post-COVID-19 patients two years after hospitalization.Methods: A prospective cohort admitted to Hospital das Clínicas da Faculdade de Medicina USP Brazil, between March and August 2020, were followed-up 6-12 months hospitalization. subset with involvement chest computed tomography (CT) scans eligible participate this second follow-up (18-24 months). Dyspnea scale...