A5017555361- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Air Quality and Health Impacts
- 3D Printing in Biomedical Research
- Inhalation and Respiratory Drug Delivery
- Nanoparticle-Based Drug Delivery
- Microplastics and Plastic Pollution
- Electrospun Nanofibers in Biomedical Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Graphene research and applications
- Noise Effects and Management
- Public Health and Nutrition
- Toxic Organic Pollutants Impact
- Boron and Carbon Nanomaterials Research
- Hydrogen's biological and therapeutic effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Tissue Engineering and Regenerative Medicine
- Material Properties and Applications
- Aerosol Filtration and Electrostatic Precipitation
- Health, Environment, Cognitive Aging
- Medical and Biological Ozone Research
- Heme Oxygenase-1 and Carbon Monoxide
- Occupational exposure and asthma
- Fiber-reinforced polymer composites
- Air Quality Monitoring and Forecasting
CSL (Switzerland)
2025
Swiss Federal Laboratories for Materials Science and Technology
2018-2024
University of St. Gallen
2020
Adolphe Merkle Institute
2015-2019
University of Fribourg
2015-2019
The growing nanoparticulate pollution (e.g. engineered nanoparticles (NPs) or nanoplastics) has been shown to pose potential threats human health. In particular, sensitive populations such as pregnant women and their unborn children need be protected from harmful environmental exposures. However, developmental toxicity prenatal exposure particles is not yet well studied despite evidence of particle accumulation in placenta. Our study aimed investigate how copper oxide NPs (CuO NPs; 10–20 nm)...
Nanocarrier design combined with pulmonary drug delivery holds great promise for the treatment of respiratory tract disorders. In particular, targeting dendritic cells that are key immune to enhance or suppress an response in lung is a promising approach allergic diseases. Fluorescently encoded poly(vinyl alcohol) (PVA)-coated gold nanoparticles, functionalized either negative (−COO–) positive (−NH3+) surface charges, were DC-SIGN antibody on particle surface, enabling binding cell receptor....
Graphene-related materials (GRMs) are subject to intensive investigations and considerable progress has been made in recent years terms of safety assessment. However, limited information is available concerning the hazard potential GRM-containing products such as graphene-reinforced composites. In present study, we conducted a comprehensive investigation biological effects particles released through an abrasion process from reduced graphene oxide (rGO)-reinforced composites polyamide 6...
Carbon nanotubes (CNTs) represent one of the most promising engineered nanomaterials, with possible applications in advanced engineering and biomedical technologies. During their production, human exposure to CNTs may occur via inhalation. Therefore, aim this study was mimic inhalation multi-walled (MWCNTs) vitro as realistically possible, by producing MWCNTs aerosols an Air-Liquid Interface Cell Exposure System (ALICE), combined a 3D epithelial airway barrier model cultivated at air-liquid...
Although acute pulmonary toxicity of carbon nanotubes (CNTs) has been extensively investigated, the knowledge potential health effects following chronic occupational exposure is currently limited and based only upon in vivo approaches. Our aim was to realistically mimic subchronic inhalation multiwalled CNTs (MWCNTs) vitro, using air–liquid interface cell (ALICE) system for aerosol exposures on reconstituted human bronchial tissue from healthy asthmatic donors. The reliability sensitivity...
The increased mass production of graphene related materials (GRM), intended for a broad spectrum applications, demands thorough assessment their potential hazard to humans and the environment. Particularly, paramount concern has been expressed in regard interaction with respiratory system occupational exposure settings. It shown that GRM are easily respirable can interact lung cells resulting induction oxidative stress or pulmonary inflammation. However, comprehensive biological effects...
We measured the cytotoxicity of pristine GRMs and abraded particles from epoxy/GRM composites, which indicated low risks to consumers such composites.
Wear particles from automotive friction brake pads of various sizes, morphology, and chemical composition are significant contributors towards particulate matter. Knowledge concerning the potential adverse effects following inhalation exposure to wear debris is limited. Our aim was, therefore, generate released commercial low-metallic non-asbestos organic used in mid-size passenger cars by a full-scale dynamometer with an environmental chamber simulating urban driving deduce their hazard...
Hexagonal boron nitride (hBN) is an emerging two-dimensional material attracting considerable attention in the industrial sector given its innovative physicochemical properties. Potential risks are associated mainly with occupational exposure where inhalation and skin contact most relevant routes for workers. Here we aimed at characterizing effects induced by composites of thermoplastic polyurethane (TPU) hBN, using immortalized HaCaT keratinocytes BEAS-2B bronchial epithelial cells. The...
Acute respiratory distress syndrome (ARDS) causes high mortality and has no specific pharmacological treatment. Scarcity of drugs against ARDS is in part due to the lack models for ARDS. As raised serum heme levels are associated with higher patients ARDS, we hypothesised that circulating contributes pathology can induce lung injury resembling human disease. We aimed develop a new model acute research heme-induced precision cut slices (PCLS). analysed its degrading enzymes along inflammatory...
Introduction: The expanding use of multiwalled carbon nanotubes (MWCNTs) in various consumer and industrial products has raised concerns regarding the potential health risks following inhalation this nanomaterial. Recent studies indicate that MWCNT exposure can cause deleterious lung effects. Pulmonary fibrosis is one diseases associated with classical fiber-shaped materials (e.g., asbestos), recently MWCNTs. Materials Methods: Herein, presented work investigated early signs key human cell...
Abstract Engineered nanomaterials have unique and novel properties enabling wide-ranging new applications in nearly all fields of research. As these raised concerns about potential adverse effects for the environment human health, extensive efforts are underway to define reliable, cost- time-effective, as well mechanistic-based testing strategies replace current method animal testing, which is still most prevalent model used risk assessment chemicals. Current approaches follow this line. The...
The risks of occupational exposure during handling multi-walled carbon nanotubes (MWCNTs) have received limited attention to date, in particular for potentially susceptible individuals with highly prevalent chronic obstructive pulmonary disease (COPD). In this vitro study, we simulated acute inhalation MWCNTs employing an air–liquid interface cell (ALICE) system: primary human bronchial epithelial cells from COPD patients and healthy donors (controls), cultured at the (ALI) were exposed...
Aim: The distribution and impact of aerosol-delivered gold nanoparticles (AuNPs) functionalized with a mixture aminated-polyvinyl alcohol amino-PEG ([polyvinyl alcohol/PEG]-NH2) upon repeated administration onto 3D lung model were explored. Materials & methods: AuNPs aerosolized uptake epithelial translocation was assessed by inductively coupled plasma optical-emission spectroscopy, flow cytometry electron microscopy. In addition, cytotoxicity, apoptosis proinflammation evaluated. Results:...
The overt hazard of carbon nanotubes (CNTs) is often assessed using in vitro methods, but determining a dose-response relationship still challenge due to the analytical difficulty quantifying dose delivered cells. An approach accurately quantify CNT doses for submerged adherent cell culture systems UV-VIS-near-infrared (NIR) spectroscopy provided here. Two types multi-walled CNTs (MWCNTs), Mitsui-7 and Nanocyl, which are dispersed protein rich media, studied as tested materials. Post 48 h...
Graphene nanoplatelet (GNP) as a nanofiller improves the mechanical strength, electrical conductivity, and flame retardancy of polymers significantly. With an increasing number GNP-reinforced products, careful safety assessment is needed to avoid social economic setbacks. However, no study has addressed effects combustion-generated emissions from products in lung, most sensitive exposure route airborne particles. Therefore, we studied influence GNP on emitted particles polycyclic aromatic...
Graphene and its derivatives are attractive materials envisaged to enable a wealth of novel applications in many fields including energy, electronics, composite or health. A comprehensive understanding the potential adverse effects graphene-related (GRM) humans is prerequisite safe use these promising materials. Here, we exploited gene expression profiling identify transcriptional responses toxicity pathways induced by graphene oxide (GO) nanoplatelets (GNP) human macrophages. Primary...
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Hexagonal boron nitride (hBN) is an emerging two-dimensional material attracting considerable attention in the industrial sector given its innovative physicochemical properties. Potential risks are associated mainly with occupational exposure where inhalation and skin contact most relevant routes for workers. Here we aimed at characterizing effects induced by composites of thermoplastic polyurethane (TPU) hBN, using immortalized HaCaT keratinocytes BEAS-2B bronchial epithelial cells. The...
Abstract Nanomedicines are promising therapeutic compounds allowing the development of new treatment approaches. However, important factors affecting behavior nanoparticles in vivo cannot be simulated conventional static models. Dynamic cell cultures, where cells cultivated presence shear stress, have potential to bridge this gap by mimicking critical features physiological conditions. Iron-carbohydrate a dominant for iron deficiency unresponsive oral supplements. Compared data available...