A5057390896- Nanoparticle-Based Drug Delivery
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Reproductive System and Pregnancy
- Graphene and Nanomaterials Applications
- Nuclear Receptors and Signaling
- Coenzyme Q10 studies and effects
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- Bladder and Urothelial Cancer Treatments
- Diamond and Carbon-based Materials Research
- Advanced Drug Delivery Systems
- Medical research and treatments
- Estrogen and related hormone effects
- Muscle metabolism and nutrition
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mesoporous Materials and Catalysis
- Polymer Nanocomposite Synthesis and Irradiation
- Environmental Sustainability and Education
- Immune cells in cancer
- Catalytic Processes in Materials Science
- Cancer Immunotherapy and Biomarkers
- Corneal Surgery and Treatments
Karolinska Institutet
2020
Universidade Estadual de Campinas (UNICAMP)
2013-2015
Pontifícia Universidade Católica de Campinas
2015
Universidade Estadual Paulista (Unesp)
2015
Described here is an anticancer material based on colloidal mesoporous silica nanoparticles (MSNs) functionalized with doxorubicin (DOX), and incorporated into Pluronic F127 hydrogels for prolonged release, a potential therapeutic application prostate cancer treatment. The MSNs have spherical morphology, size of about 60 nm, surface area 970 cm2 g–1 average pore width 2.0 nm. A high stability the in physiological medium used vivo administration (NaCl 0.9% w/v) could be attained presence...
ABSTRACT In Duchenne muscle dystrophy (DMD) and in the mdx mouse model of DMD, a lack dystrophin leads to myonecrosis cardiorespiratory failure. Several lines evidence suggest detrimental role inflammatory process dystrophic process. Previously, we demonstrated that short‐term therapy with eicosapentaenoic acid (EPA), at early stages disease, ameliorated progression mouse. present study, evaluated effects long‐term omega‐3 later progression. Three‐month‐old mice received (300 mg/kg) or...
Estrogen receptor beta (ERβ), encoded by the Esr2 gene, is one of two nuclear receptors that mediate functions steroid hormone estradiol. The binding estradiol to results in enhanced transcription many genes have estrogen response elements promoter or enhancer regions. Several genetically modified mouse lines with mutations deletions exons gene been developed and from analysis these are not completely consistent, especially regarding ERβ's role fertility. To address controversies, we used...
We describe here a drug depot hydrogel system comprising sildenafil (Viagra®) incorporated in mesoporous silica nanoparticles (60 nm) and conjugated with thermosensitive poloxamer, which presents high efficiency against prostate cancer.
One of the major problems in cancer therapies is high occurrence side effects intrinsic anticancer drugs. Doxorrubicin a conventional molecule used to treat wide range cancer, such as breast, ovarian and prostate. However, its use associated with number like multidrug resistance cardiotoxicity. The association nanomaterials has been considered past decade overcome toxicity these In this context, mesoporous silica nanoparticles are great candidates be carriers once they very biocompatible....
Este trabalho apresenta relato e reflexões acerca da experiência de estágio supervisionado realizado em um espaço educação não formal na Universidade Estadual Campinas por alunos dos cursos Licenciatura Ciências Biológicas Matemática. Em grupo faixa etária 11 a 14 anos foram desenvolvidas atividades que visavam à exploração perspectiva social ambiental das ações relações consumo. Assim, percebeu-se mídia exercia importante papel nas decisões relativas ao consumo profusão modelo...
Because of high occurrence side effects conventional anticancer drugs, new therapies have been widely studied, such as the use non-usual molecules and association with nanomaterials.In this context, sildenafil is a molecule that has lately considered co-adjuvant in cancer therapy because it inhibits an enzyme potential role tumor progression, phosphodiesterase-5.Taking into account combination nanoparticles sildenafil, we produced systems based on mesoporous silica nanoparticles, Pluronic...