Carla Lança

ORCID: 0000-0001-9918-787X
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About
Contact & Profiles
Research Areas
  • Ophthalmology and Visual Impairment Studies
  • Corneal surgery and disorders
  • Retinal Diseases and Treatments
  • Glaucoma and retinal disorders
  • Retinal Imaging and Analysis
  • Obesity, Physical Activity, Diet
  • Retinopathy of Prematurity Studies
  • Visual perception and processing mechanisms
  • Ophthalmology and Visual Health Research
  • Birth, Development, and Health
  • Reading and Literacy Development
  • Ophthalmology and Eye Disorders
  • Health, Education, and Aging
  • Ergonomics and Musculoskeletal Disorders
  • Radiology practices and education
  • Digital Imaging in Medicine
  • Radiation Dose and Imaging
  • Tactile and Sensory Interactions
  • Impact of Light on Environment and Health
  • Ocular Surface and Contact Lens
  • AI in cancer detection
  • Mobile Health and mHealth Applications
  • Digital Radiography and Breast Imaging
  • Education and Technology Integration
  • Urban Green Space and Health

New York University
2024-2025

Universidade Nova de Lisboa
2017-2025

Instituto Politécnico de Lisboa
2013-2025

New York University Abu Dhabi
2025

Singapore Eye Research Institute
2019-2024

Escola Nacional de Saúde Pública
2013-2024

Singapore National Eye Center
2019-2024

University of Warmia and Mazury in Olsztyn
2022

Charité - Universitätsmedizin Berlin
2022

Hospital Posadas
2022

Purpose: We studied biometry changes before and after myopia onset in a cohort of Singaporean children. Methods: All data were taken from the Singapore Cohort Study Risk Factors for Myopia (SCORM). Participants underwent refraction measurements with follow-up 3 to 6 years. The longitudinal ocular (spherical equivalent refraction, axial length, lens power) compared between children who suffered during study (N = 303), emmetropic 490), myopic at baseline 509). Results: At onset, shift...

10.1167/iovs.18-26247 article EN cc-by-nc-nd Investigative Ophthalmology & Visual Science 2019-07-19

Our study aims to identify children at risk of developing high myopia for timely assessment and intervention, preventing progression complications in adulthood through the development a deep learning system (DLS). Using school-based cohort Singapore comprising 998 (aged 6-12 years old), we train perform primary validation DLS using 7456 baseline fundus images 1878 eyes; with external an independent test dataset 821 189 eyes together clinical data (age, gender, race, parental myopia,...

10.1038/s41746-023-00752-8 article EN cc-by npj Digital Medicine 2023-01-26
Jonathan P. Bradfield Rachel L. Kember Anna Ulrich Zhanna Balkhiyarova Akram Alyass and 95 more Izzuddin M. Aris Joshua A. Bell K. Alaine Broadaway Zhanghua Chen Jin Fang Chai Neil M Davies Dietmar Fernández‐Orth Mariona Bustamante Ruby Fore Amitavo Ganguli Anni Heiskala Jouke‐Jan Hottenga Carmen Íñiguez Sayuko Kobes Jaakko T. Leinonen Estelle Lowry Leo‐Pekka Lyytikäinen Anubha Mahajan Niina Pitkänen Theresia M. Schnurr Henri Theil David P. Strachan Elisabeth Thiering Suzanne Vogelezang Kaitlin H. Wade Carol A. Wang Andrew Wong Louise Aas Holm Alessandra Chesi Catherine S. Choong Miguel Cruz Paul Elliott Steve Franks Christine Frithioff‐Bøjsøe W. James Gauderman Joseph Glessner Vicente Gilsanz Kendra Griesman Robert L. Hanson Marika Kaakinen Heidi J. Kalkwarf Andrea Kelly Joseph M. Kindler Mika Kähönen Carla Lança Joan M. Lappe Sang Lee Shana E. McCormack Frank Mentch Jonathan A. Mitchell Nina Mononen Harri Niinikoski Emily Oken Katja Pahkala Xueling Sim Yik‐Ying Teo Leslie J. Baier C.E.M. van Beijsterveldt Linda S. Adair Dorret I. Boomsma Eco J. C. de Geus Mònica Guxens Johan G. Eriksson Janine F. Felix Frank D. Gilliland Penn Medicine BioBank Torben Hansen Rebecca Hardy Marie‐France Hivert Jens‐Christian Holm Vincent W. V. Jaddoe Marjo‐Riitta Järvelin Terho Lehtimäki David A. Mackey David Meyre Karen L. Mohlke Juha Mykkänen Sharon E. Oberfield Craig E. Pennell John R. B. Perry Olli T. Raitakari Fernando Rivadeneira Seang‐Mei Saw Sylvain Sebért John Shepherd Marie Standl Thorkild I. A. Sørensen Nicholas J. Timpson Maties Torrent Gonneke Willemsen Elina Hyppönen Chris Power Mark I. McCarthy Rachel M. Freathy Elisabeth Widén

Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating trajectories remain largely unknown. Here, we modeled longitudinal height Super-Imposition by Translation And Rotation (SITAR) curve analysis on ~ 56,000 trans-ancestry samples repeated measurements from age 5 years to adulthood. We performed six phenotypes representing magnitude, timing, and intensity of pubertal spurt. To investigate lifelong impact variants associated trajectories,...

10.1186/s13059-023-03136-z article EN cc-by Genome biology 2024-01-16

Lack of outdoor time is a known risk factor for myopia. Knowledge the light levels reaching eye and exposure settings, including sun-protective measures, essential programs We evaluated impact strategies (hat sunglasses) on maintaining high illuminance to prevent myopia.A child-sized mannequin head was developed measure with without equipment, across wide range environments in Singapore, outdoors (open park, under tree, street) indoors (under fluorescent illumination window, white LED-based...

10.1167/tvst.8.4.7 article EN cc-by-nc-nd Translational Vision Science & Technology 2019-07-18

To examine the association between near work, screen time including TV and outdoor with myopia in children from Sunflower Myopia Asian Eye Epidemiology Consortium (AEEC).We analysed AEEC cross-sectional data (12 241 children) on risk factors (near time) of six population-based studies (China, Hong Kong Singapore). Cycloplegic refraction axial length (AL) measurements were included. Risk determined using questionnaires. Data pooled each study, multivariable regression analysis was performed...

10.1111/aos.14942 article EN Acta Ophthalmologica 2021-06-17

Background/aims To evaluate the association of reported time outdoors and light exposure patterns with myopia among children aged 9 years from Growing Up in Singapore Towards Healthy Outcomes birth cohort. Methods We assessed (min/day), outdoor activities (n=483) a questionnaire, FitSight watch 7-day activity diary. Light levels, duration, timing frequency were assessed. Cycloplegic spherical equivalent (SE), (SE≤−0.5 D) axial length (AL) paired eyes analysed using generalised estimating...

10.1136/bjophthalmol-2021-318918 article EN British Journal of Ophthalmology 2021-04-15

Animal models have shown that the absence of high-frequency visual information can precipitate onset myopia, but this relationship remains unclear in humans. This study aims to explore association between spatial frequency content environment and myopia children.

10.1136/bjo-2024-325888 article EN British Journal of Ophthalmology 2024-08-08

Aims To determine the prevalence and predictors of myopic macular degeneration (MMD) in a consortium Asian studies. Methods Individual-level data from 19 885 participants four population-based studies, 1379 highly (defined as axial length (AL) >26.0 mm) three clinic-based/school-based studies Eye Epidemiology Consortium were pooled. MMD was graded fundus photographs following meta-analysis for pathologic myopia classification defined presence diffuse choroidal atrophy, patchy...

10.1136/bjophthalmol-2020-316648 article EN British Journal of Ophthalmology 2020-09-02

Abstract Purpose To compare 3‐year myopic progression between Finnish and Singaporean children. Methods Myopic was compared 9‐year‐old (mean age 9.7 ± 0.4 years, n = 92) 11‐year‐old 11.7 144) (Finnish RCT) children matched by refraction (SCORMMatched, 403) 7‐ to 8‐year‐old only (SCORM Young, 186). Spherical equivalent (SE) −0.50 −3.00 D. Refraction with cycloplegia controlled annually for 3 years. Information on parental myopia, mother’s education, time spent near‐work outdoor gathered...

10.1111/aos.14545 article EN cc-by-nc-nd Acta Ophthalmologica 2020-07-24

The development of tools to predict the risk myopia onset and progression has increased in past few years. Currently, several control therapies are available slow rate progression. Additionally, environmental counselling, such as increasing outdoor time, can be used delay myopia. However, assessment need for treatment or counselling is dependent on an evaluation develop Several have been developed, percentile growth curves artificial intelligence curve estimations refractive error axial...

10.1111/aos.16889 article EN Acta Ophthalmologica 2025-01-01

Aims To investigate whether industry-sponsored randomised control trials (RCT) on myopia have more favourable outcomes and differ in risk of bias, compared with studies having other sources sponsorship. Methods PubMed, Embase MEDLINE were searched until 6 October 2023. RCTs interventions included if they reported spherical equivalent (SE) and/or axial length (AL) changes. We pooled the mean differences 95% CIs SE AL changes using a random-effects model. calculated both ratio (RR) adjusted OR...

10.1136/bjo-2024-326347 article EN British Journal of Ophthalmology 2025-03-13
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