Abraham A. Palmer
A5031236440- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Neurotransmitter Receptor Influence on Behavior
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- Substance Abuse Treatment and Outcomes
- Alcohol Consumption and Health Effects
- Behavioral Health and Interventions
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Nutrition, Genetics, and Disease
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Decision-Making and Behavioral Economics
- Biochemical Analysis and Sensing Techniques
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Genetics and Plant Breeding
- Eating Disorders and Behaviors
- Neuropeptides and Animal Physiology
- Peroxisome Proliferator-Activated Receptors
- Attention Deficit Hyperactivity Disorder
- Muscle Physiology and Disorders
University of California, San Diego
2016-2025
Università di Camerino
2024-2025
Medical University of South Carolina
2024-2025
Jacksonville State University
2025
Wake Forest University
2025
The Ohio State University
2024
McMaster University
2023
University of Colorado Anschutz Medical Campus
2022
University of Tennessee Health Science Center
2022
Scripps (United States)
2022
Abstract The JAX Diversity Outbred population is a new mouse resource derived from partially inbred Collaborative Cross strains and maintained by randomized outcrossing. As such, it segregates the same allelic variants as but embeds these in distinct architecture which each animal has high degree of heterozygosity carries unique combination alleles. Phenotypic diversity striking often divergent phenotypes seen founder Cross. Allele frequencies recombination density early generations mice are...
Genetic mapping studies in the mouse and other model organisms are used to search for genes underlying complex phenotypes. Traditional genetic that employ single-generation crosses have poor resolution limit discovery loci polymorphic between two parental strains. Multiparent outbreeding populations address these shortcomings by increasing density of recombination events introducing allelic variants from multiple founder However, multiparent present new analytical challenges require...
Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology treatment psychopathology. Here, we combine transdiagnostic dimensional approaches genetic discovery for the first time, conducting a novel multivariate genome-wide association study eight psychiatric symptoms disorders broadly related mood disturbance psychosis. We identify two liabilities that distinguish between common forms...
Abstract Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency act prematurely and associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies (GWAS) eight impulsive personality traits from Barratt Impulsiveness Scale short UPPS-P Impulsive Personality ( N = 123,509–133,517 23andMe research participants European ancestry), measure Drug Experimentation 130,684). Because these GWAS...
The behavioral and diagnostic heterogeneity within the opioid use disorder (OUD) diagnosis is not readily captured in current animal models, limiting translational relevance of mechanistic research that conducted experimental animals. authors hypothesized a nonlinear clustering OUD-like traits would capture population yield subpopulations OUD vulnerable rats with distinct neurocircuit profiles. Over 900 male female heterogeneous stock rats, line capturing genetic present humans, were...
Separate breeding colonies of C57BL/6 (“B6”) mice maintained at the Jackson Laboratories (“J”) and NIH (“N”) have led to emergence two distinct substrains mice: C57BL/6J C57BL/6N. Molecular genetic studies indicate simple sequence-length polymorphisms, single-nucleotide copy-number variants among B6 that may contribute phenotypic differences. We examined differences in motor coordination, pain sensitivity, conditional fear strain three N strains: C57BL/6NCrl (Charles River), C57BL/6NTac...
Most single-gene diseases, including muscular dystrophy, display a nonuniform phenotype. Phenotypic variability arises, in part, due to the presence of genetic modifiers that enhance or suppress disease process. We employed an unbiased mapping approach search for genes modify dystrophy mice. In genome-wide scan, we identified single strong locus on chromosome 7 influenced two pathological features muscle membrane permeability and fibrosis. Within this genomic interval, insertion/deletion...
Genetic reference populations in model organisms are critical resources for systems genetic analysis of disease related phenotypes. The breeding history these inbred panels may influence detectable allelic and phenotypic diversity. existing panel common strains reflects historical selection biases, recombinant have low All such be subject to consequences inbreeding depression. Collaborative Cross (CC) is a mouse population with high diversity that being constructed using randomized design...