A5039501195- Gene expression and cancer classification
- Hemoglobinopathies and Related Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Erythrocyte Function and Pathophysiology
- Genetic Associations and Epidemiology
- Blood groups and transfusion
- Epigenetics and DNA Methylation
- Neonatal Health and Biochemistry
- Genetic and phenotypic traits in livestock
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Adipose Tissue and Metabolism
- Iron Metabolism and Disorders
- Molecular Biology Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Blood donation and transfusion practices
- Birth, Development, and Health
- HIV/AIDS Research and Interventions
- Neonatal and fetal brain pathology
- HIV Research and Treatment
- Erythropoietin and Anemia Treatment
- Metabolomics and Mass Spectrometry Studies
- Genetics, Bioinformatics, and Biomedical Research
- Diet and metabolism studies
RTI International
2015-2025
Clinical Research Atlanta
2025
Cleveland Clinic
2023
University of California, San Diego
2022
San Diego Supercomputer Center
2022
University of Utah
2013-2020
RELX Group (Netherlands)
2013-2015
Office of Public Health Genomics
2015
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2013-2015
Research Network (United States)
2015
Coexpression patterns of gene expression across many microarray data sets may reveal networks genes involved in linked processes. To identify factors cellulose biosynthesis, we used a regression method to analyze 408 publicly available Affymetrix Arabidopsis microarrays. Expression previously implicated synthesis, as well several uncharacterized genes, was highly coregulated with synthase (CESA) genes. Four candidate which were coexpressed CESA secondary cell wall investigated by mutant...
Annual plants grow vegetatively at early developmental stages and then transition to the reproductive stage, followed by senescence in same year. In contrast, after successive years of vegetative growth ages, woody perennial shoot meristems begin repeated transitions between sexual maturity. However, it is unknown how these occur without a conflict growth. We report that functionally diverged paralogs FLOWERING LOCUS T1 ( FT1 ) T2 FT2 ), products whole-genome duplication homologs Arabidopsis...
Abstract Molecular studies of squamous cell carcinoma the head and neck (HNSCC) have demonstrated multiple genetic abnormalities such as activation various oncogenes (Ras, Myc, epidermal growth factor receptor, cyclin D1), tumor suppressor gene inactivation (TP53 p16), loss heterozygosity at numerous chromosomal locations. Despite these observations, accurate reliable biomarkers that predict patients highest risk for local recurrence yet to be defined. In an effort identify expression...
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we large polymorphic deletion that encodes tandem repeats putative brain-related transcription factor binding sites in intron 2 DCDC2 . Alleles this compound repeat are significant disequilibrium multiple traits. RT-PCR data show localizes to regions brain where fluent occurs, and RNA interference studies down-regulation...
Intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia remain significant causes of morbidity mortality in preterm newborns.Our goal was to assess the familial genetic susceptibility intraventricular dysplasia.Mixed-effects logistic-regression latent variable probit model analysis were used contribution several covariates a multicenter retrospective study 450 twin pairs born at < or =32 weeks gestation. To determine contribution, concordance rates subset 252...
Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable result from loss of NF1 tumor suppressor gene function, causing hyperactive Ras signaling. Activated controls numerous downstream effectors, but specific pathways mediating the effects in are unknown. We performed cross-species transcriptome analyses mouse human MPNSTs identified global negative feedback genes that regulate Ras/Raf/MEK/ERK signaling both...
Genetic abnormalities have been associated with 6 to 13% of stillbirths, but the true prevalence may be higher. Unlike karyotype analysis, microarray analysis does not require live cells, and it detects small deletions duplications called copy-number variants. The Stillbirth Collaborative Research Network conducted a population-based study stillbirth in five geographic catchment areas. Standardized postmortem examinations analyses were performed. A single-nucleotide polymorphism array was...
Key Points Genetic and biological variability in blood donors may impact RBC predisposition to hemolysis during cold storage after transfusion. Male sex, Asian or African American racial background, older age (>45 years) are significant modifiers of hemolysis.
Abstract The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of (NIH) 2016 to improve children’s health United States. EWC harmonizes extant data and collects new using standardized protocol, ECHO-Wide Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but frequency timing vary across cohorts. As March 4, 2022,...
Ischemia/reperfusion (IR) injury in transplanted livers contributes to organ dysfunction and failure is characterized part by loss of NO bioavailability. Inhalation nontoxic at high concentrations (80 ppm) inhibits IR extrapulmonary tissues. In this prospective, blinded, placebo-controlled study, we evaluated the hypothesis that administration inhaled (iNO; 80 patients undergoing orthotopic liver transplantation hepatic injury, resulting improved function. Patients were randomized receive...
Patterns of coexpression can reveal networks functionally related genes and provide deeper understanding processes requiring multiple gene products. We performed an analysis for 1,330 from the AraCyc database metabolic pathways in Arabidopsis (Arabidopsis thaliana). found that associated with same pathway are, on average, more highly coexpressed than different pathways. Positively within tend to cluster close together structure, while negatively correlated typically occupy distant positions....
Global activation of the embryonic genome is most critical event in early mammalian development. After fertilization, a rich supply maternal proteins and RNAs support development whereas number zygotic genes are expressed stage-specific manner leading to (EGA). However, identities mechanism(s) EGA poorly defined bovine. Using Affymetrix bovine-specific DNA microarray as biggest available array at present, we analyzed gene expression two key stages bovine development, matured oocytes (MII)...
One third of patients with type 1 diabetes and microalbuminuria experience an early, progressive decline in renal function that leads to advanced stages chronic kidney disease ESRD. We hypothesized the urinary proteome may distinguish between stable early among microalbuminuria. followed normal for 10 12 yr classified them into case (n = 21) control subjects 40) function. Using liquid chromatography matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we identified...
Red blood cell storage in the bank promotes progressive accumulation of metabolic alterations that may ultimately impact erythrocyte capacity to cope with oxidant stressors. However, underpinnings RBCs resist stress and potential donor biology on this phenotype are not known. Within framework REDS-III RBC-Omics study, from 8,502 healthy donors were stored for 42 days tested their propensity hemolyze following stress. A subset extreme hemolyzers donated a second unit blood, which was 10, 23,...
BACKGROUND Biological and technical variability has been increasingly appreciated as a key factor impacting red blood cell (RBC) storability and, potentially, transfusion outcomes. Here, we performed metabolomics analyses to investigate the impact of factors other than storage duration on metabolic phenotypes stored RBC in multicenter study. STUDY DESIGN AND METHODS Within framework REDS‐III (Recipient Epidemiology Donor Evaluation Study‐III) RBC‐Omics study, 13,403 donors were enrolled from...