A5018533843- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Infant Development and Preterm Care
- Clinical Nutrition and Gastroenterology
- Neonatal and Maternal Infections
- Metabolism and Genetic Disorders
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- Sepsis Diagnosis and Treatment
- Animal Nutrition and Physiology
- Streptococcal Infections and Treatments
- Global Maternal and Child Health
- Congenital Heart Disease Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Pregnancy and preeclampsia studies
- Respiratory Support and Mechanisms
- Child Nutrition and Water Access
- Child and Adolescent Health
- Neonatal Health and Biochemistry
- Amino Acid Enzymes and Metabolism
Emory University
2016-2025
Emory and Henry College
2012-2025
Baylor College of Medicine
2015-2025
Research Network (United States)
2011-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2005-2025
Health and Human Development (2HD) Research Network
2004-2025
China Medical Board
2023-2025
Children's Healthcare of Atlanta
2015-2024
Children's Nutrition Research Center at Baylor College of Medicine
2015-2024
Agricultural Research Service
2014-2024
Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia term infants with encephalopathy uncertain. We conducted a randomized trial gestational age at least 36 weeks who were admitted to hospital or before six hours either severe acidosis perinatal complications resuscitation birth had moderate encephalopathy. Infants randomly assigned usual care (control group) whole-body cooling an esophageal temperature 33.5...
This report presents data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network on care morbidity mortality rates for very low birth weight infants, according to gestational age (GA). Perinatal/neonatal were collected 9575 infants extremely GA (22-28 weeks) (401-1500 g) who born at network centers between January 1, 2003, December 31, 2007. Rates survival discharge increased with increasing (6% 22 weeks 92% 28 weeks); 1060 died...
<h3>Importance</h3> Extremely preterm infants contribute disproportionately to neonatal morbidity and mortality. <h3>Objective</h3> To review 20-year trends in maternal/neonatal care, complications, mortality among extremely born at Neonatal Research Network centers. <h3>Design, Setting, Participants</h3> Prospective registry of 34 636 infants, 22 28 weeks' gestation, birth weight 401 1500 g, 26 network centers between 1993 2012. <h3>Exposures</h3> birth. <h3>Main Outcomes Measures</h3>...
Objective. Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants. To determine the current incidence late-onset sepsis, risk factors for disease, and impact on subsequent hospital course, we evaluated a cohort 6956 VLBW (401–1500 g) neonates admitted to clinical centers National Institute Child Health Human Development Neonatal Research Network over 2-year period (1998–2000). Methods. The maintains prospective registry all...
Neonatal infections are frequent complications of extremely low-birth-weight (ELBW) infants receiving intensive care. To determine if neonatal in ELBW associated with increased risks adverse neurodevelopmental and growth sequelae early childhood. Infants weighing 401 to 1000 g at birth (born 1993-2001) were enrolled a prospectively collected very registry academic medical centers participating the National Institute Child Health Human Development Research Network. Neurodevelopmental outcomes...
Objectives. To determine the mortality and morbidity for infants weighing 401 to 1500 g (very low birth weight [VLBW]) at by gestational age, weight, gender. Study Design. Perinatal data were collected prospectively on an inborn cohort from January 1995 through December 1996 14 participating centers of National Institute Child Health Human Development Neonatal Research Network compared with corresponding previous reports. Sociodemographic factors, perinatal events, neonatal course 120 days...
BACKGROUND: Guidelines for prevention of group B streptococcal (GBS) infection have successfully reduced early onset (EO) GBS disease. Study results suggest that Escherichia coli is an important EO pathogen. OBJECTIVE: To determine rates, pathogens, morbidity, and mortality in a national network neonatal centers. METHODS: Infants with were identified by prospective surveillance at Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Network Infection was defined...
Our objectives were to identify factors associated with the duration of first antibiotic course initiated in 3 postnatal days and assess associations between initial subsequent necrotizing enterocolitis or death extremely low birth weight infants sterile culture results.We conducted a retrospective cohort analysis admitted tertiary centers 1998-2001. We defined empirical treatment as continuous therapy started results. used descriptive statistics characterize center practice, bivariate...
Background. The interpretation of growth rates for very low birth weight infants is obscured by limited data, recent changes in perinatal care, and the uncertain effects multiple therapies. Objectives. To develop contemporary postnatal curves preterm to relate velocity weight, nutritional practices, fetal status (small- or appropriate-for-gestational-age), major neonatal morbidities (chronic lung disease, nosocomial infection late-onset infection, severe intraventricular hemorrhage,...
It is uncertain whether the rates and causes of early-onset sepsis (that occurring within 72 hours after birth) among very-low-birth-weight infants have changed in recent years, since antibiotics begun to be used more widely during labor delivery.
Objectives. Necrotizing enterocolitis (NEC) is a significant complication for the premature infant. However, subsequent neurodevelopmental and growth outcomes of extremely low birth weight (ELBW) infants with NEC have not been well described. We hypothesized that ELBW surgically managed (SurgNEC) are at greater risk poor than medically (MedNEC) compared without history (NoNEC). The objective this study was to compare growth, neurologic, cognitive among survivors SurgNEC MedNEC NoNEC 18 22...
BACKGROUND. Neonatal candidiasis is associated with substantial morbidity and mortality rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been reported. METHODS. Data were collected prospectively neonates born at &lt;1000 g National Institute of Child Health Human Development-sponsored Research Network sites between September 1, 1998, December 31, 2001. Uniform evaluations, including assessments mental motor development the Bayley Scales Infant Development...
Understanding the causes and timing of death in extremely premature infants may guide research efforts inform counseling families. We analyzed prospectively collected data on 6075 deaths among 22,248 live births, with gestational ages 22 0/7 to 28 6/7 weeks, born study hospitals within National Institute Child Health Human Development Neonatal Research Network. compared overall cause-specific in-hospital mortality across three periods from 2000 through 2011, adjustment for baseline...
Between-hospital variation in outcomes among extremely preterm infants is largely unexplained and may reflect differences hospital practices regarding the initiation of active lifesaving treatment as compared with comfort care after birth. We studied born between April 2006 March 2011 at 24 hospitals included Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. Data were collected for 4987 before 27 weeks gestation without congenital anomalies....
Objectives. In the era before widespread use of inhaled nitric oxide, to determine prevalence persistent pulmonary hypertension (PPHN) in a multicenter cohort, demographic descriptors population, treatments used, outcomes those treatments, and variation practice among centers. Study Design. A total 385 neonates who received ≥50% inspired oxygen and/or mechanical ventilation had documented evidence PPHN (2D echocardiogram or preductal postductal difference) were tracked from admission at 12...
Vitamin A supplementation may reduce the risk of chronic lung disease and sepsis in extremely-low-birth-weight infants. The results our pilot study suggested that a dose 5000 IU administered intramuscularly three times per week for four weeks was more effective than lower doses given past trials.
Early administration of high doses dexamethasone may reduce the risk chronic lung disease in premature infants but can cause complications. Whether moderate would be as effective safer is not known.
Sepsis in the first 3 days of life is a leading cause morbidity and mortality among infants. Group B Streptococcus (GBS), historically primary early-onset sepsis (EOS), has declined through widespread use intrapartum chemoprophylaxis. We estimated national burden invasive EOS cases deaths era GBS prevention.
Despite improvement during recent decades, extremely preterm infants continue to contribute disproportionately neonatal mortality and childhood morbidity. To review survival, in-hospital morbidities, care practices, neurodevelopmental functional outcomes at 22-26 months' corrected age for infants. Prospective registry born 19 US academic centers that are part of the Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. The study included 10 877...