A5069169403- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Sepsis Diagnosis and Treatment
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive tract infections research
- Antimicrobial Resistance in Staphylococcus
- Syphilis Diagnosis and Treatment
- Legionella and Acanthamoeba research
- Vaccine Coverage and Hesitancy
- Immunodeficiency and Autoimmune Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Microscopic Colitis
- Bacterial biofilms and quorum sensing
- Diabetic Foot Ulcer Assessment and Management
- Emergency and Acute Care Studies
- Vector-borne infectious diseases
- Bacterial Identification and Susceptibility Testing
- Maternal and Neonatal Healthcare
- Reproductive Health and Contraception
- Hepatitis B Virus Studies
- Nosocomial Infections in ICU
Centers for Disease Control and Prevention
2013-2024
National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention
2024
The Centers
2024
National Center for Immunization and Respiratory Diseases
2009-2021
Epidemic Intelligence Service
2020
Centers for Disease Control and Prevention
2016
Children's Healthcare of Atlanta
2011
Emory University
2011
Sepsis in the first 3 days of life is a leading cause morbidity and mortality among infants. Group B Streptococcus (GBS), historically primary early-onset sepsis (EOS), has declined through widespread use intrapartum chemoprophylaxis. We estimated national burden invasive EOS cases deaths era GBS prevention.
Group B Streptococcus (GBS) and Escherichia coli have historically dominated as causes of early-onset neonatal sepsis. Widespread use intrapartum prophylaxis for GBS disease led to concerns about the potential adverse impact on E incidence.Active, laboratory, population-based surveillance culture-positive (blood or cerebrospinal fluid) bacterial infections among infants 0 2 days age was conducted statewide in Minnesota Connecticut selected counties California Georgia during 2005 2014....
Invasive group A Streptococcus (GAS) infections are associated with significant morbidity and mortality rates. We report the epidemiology trends of invasive GAS over 8 years surveillance.From January 2005 through December 2012, we collected data from Centers for Disease Control Prevention's Active Bacterial Core surveillance, a population-based network 10 geographically diverse US sites (2012 population, 32.8 million). defined as isolation normally sterile site or wound in patient...
In January 2005, a quadrivalent (serogroups A, C , Y, and W-135) meningococcal conjugate vaccine was licensed for use in adolescents. This report describes the epidemiologic features of disease United States from 1998 through December 2007, before during implementation adolescent vaccination.Data were collected active surveillance invasive Neisseria meningitidis conducted Active Bacterial Core (ABCs) sites 1998-2007. Isolates cases serogrouped at ABCs site confirmed Centers Disease Control...
<h3>Importance</h3> Invasive disease owing to group B<i>Streptococcus</i>(GBS) remains an important cause of illness and death among infants younger than 90 days in the United States, despite declines early-onset (EOD; with onset at 0-6 life) that are attributed intrapartum antibiotic prophylaxis (IAP). Maternal vaccines prevent infant GBS currently under development. <h3>Objective</h3> To describe incidence rates, case characteristics, antimicrobial resistance, serotype distribution EOD...
Group B Streptococcus (GBS) is an important cause of invasive bacterial disease. Previous studies have shown a substantial and increasing burden GBS infections among nonpregnant adults, particularly older adults those with underlying medical conditions.
Antibiotic-nonsusceptible invasive pneumococcal disease (IPD) decreased substantially after the US introduction of pediatric 7-valent conjugate vaccine (PCV7) in 2000. However, rates antibiotic-nonsusceptible non-PCV7-type IPD increased during 2004-2009. In 2010, 13-valent (PCV13) replaced PCV7. We assessed impact PCV13 on rates.We defined as isolation from a normally sterile site resident 10 surveillance sites. isolates were those intermediate or resistant to ≥1 antibiotic classes according...
Following Haemophilus influenzae serotype b (Hib) conjugate vaccine introduction in the 1980s, Hib disease young children dramatically decreased, and epidemiology of invasive H. changed.
Since the establishment of sequence-based typing as gold standard for DNA-based Legionella pneumophila, laboratory at Centers Disease Control and Prevention (CDC) has conducted routine (SBT) analysis all incoming L. pneumophila serogroup 1 (Lp1) isolates to identify potential links between cases better understand genetic diversity clonal expansion among bacteria. Retrospective genotyping Lp1 from sporadic Legionnaires' disease (LD) outbreaks deposited into CDC reference collection since 1982...
The 13-valent pneumococcal vaccine (PCV13) was introduced for US children in 2010 and immunocompromised adults ≥19 years old series with the 23-valent polysaccharide (PPSV23) 2012. We evaluated PCV13 indirect effects on invasive disease (IPD) among without indications.Using Active Bacterial Core surveillance National Health Survey, using Interview we estimated compared IPD incidence 2013-2014 2007-2008, by age serotype group (PCV13, PPSV23-unique, or nonvaccine types [NVTs]), indications.IPD...
Rates of invasive group B Streptococcus (GBS) disease, obesity, and diabetes have increased in US adults. We hypothesized that obesity would be independently associated with an risk GBS disease.We identified adults disease within Active Bacterial Core surveillance during 2010-2012 used population estimates from the Behavioral Risk Factor Surveillance System to calculate incidence rates. estimated relative risks (RRs) using Poisson analysis offset denominators, categorized as class I/II (body...
Background Globally, over 400,000 neonatal deaths in 2015 were attributed to sepsis, however, the incidence and etiologies of these infections are largely unknown low-middle income countries. We aimed determine etiology community-acquired early-onset (<72 hours age) sepsis (EOS) using culture molecular diagnostics. Methods This was a prospective observational study, which we conducted surveillance for pathogens combination blood polymerase chain reaction (PCR)-based test. Blood performed on...
<h3>Importance</h3> In 2005, the US Advisory Committee on Immunization Practices recommended routine quadrivalent meningococcal conjugate (MenACWY) vaccine for all adolescents aged 11 to 12 years, and in 2010, a booster dose 16 years. Measuring association between MenACWY vaccination incidence of disease is critical evaluating adolescent program informing future policy. <h3>Objective</h3> To describe adolescents. <h3>Design, Setting, Participants</h3> this cohort study, analysis surveillance...
The incidence of meningococcal disease is currently at historic lows in the United States; however, remains highest among infants aged <1 year. With routine use Haemophilus influenzae type b and pneumococcal vaccines children States, Neisseria meningitidis an important cause bacterial meningitis young children.Data were collected from active, population- laboratory-based surveillance for N conducted through Active Bacterial Core during 2006 2012. Expanded data collection forms completed...
Invasive group A Streptococcus (iGAS) infections cause significant morbidity and mortality worldwide. We analyzed whether obesity diabetes were associated with iGAS worse outcomes among an adult US population.
BACKGROUND: Most countries use 3-dose pneumococcal conjugate vaccine (PCV) schedules; a 4-dose (3 primary and 1 booster) schedule is licensed for US infants. We evaluated the invasive disease (IPD) breakthrough infection incidence in children receiving 2 vs 3 PCV doses with without booster (2 + 1; 0 0). METHODS: used 2001–2016 Active Bacterial Core surveillance data to identify infections (vaccine-type IPD ≥1 7-valent [PCV7] or 13-valent [PCV13] dose) among aged &lt;5 years. estimated...
Background. Meningococcal disease incidence in the United States is at an all-time low. In a previous study of Georgia high school students, meningococcal carriage prevalence was 7%. The purpose this to measure impact conjugate vaccine on serogroup Y and define dynamics students. Methods. This prospective cohort 8 schools, 4 each Maryland Georgia, during year. Students participating schools received quadrivalent that uses diphtheria toxoid as protein carrier (MCV4-DT). state, 2 were randomly...
Introduction Etiology studies of severe acute respiratory infections (SARI) in adults are limited. We studied potential etiologies SARI among six countries using multi-pathogen diagnostics. Methods enrolled both with (acute illness onset fever and cough requiring hospitalization) asymptomatic (adults hospitalized non-infectious illnesses, non-household members accompanying patients, from outpatient departments, community members) each country. Demographics, clinical data, nasopharyngeal...
Background. Group A Streptococcus (GAS) is an important bacterial cause of life-threatening illness among the elderly. Public health officials investigated a protracted GAS outbreak in skilled nursing facility Georgia housing patients requiring 24-hour or rehabilitation, to prevent additional cases. Methods. We defined case as resident with onset after January 2009 isolated from usually sterile (invasive) nonsterile site (noninvasive). Cases were "recurrent" if >1 month elapsed between...
BackgroundChlamydia pneumoniae illness is poorly characterized, particularly as a sole causative pathogen. We investigated C. outbreak at federal correctional facility.
Background. Before the introduction of 7-valent pneumococcal conjugate vaccine (PCV7), invasive disease (IPD) rates among blacks were twice in whites. We measured effects trends PCV7-type and non-PCV7-type IPD on racial disparities overall estimated proportion caused by serotypes included 13-valent (PCV13). Methods. analyzed data from Active Bacterial Core surveillance system, which performs active, laboratory- population-based for 29.2 million people United States, period 1998–2009. For...