A5058364000- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Infective Endocarditis Diagnosis and Management
- COVID-19 epidemiological studies
- Bacterial Infections and Vaccines
- Child and Adolescent Health
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Diabetes and associated disorders
- Radioactivity and Radon Measurements
- Health disparities and outcomes
- Influenza Virus Research Studies
- Maternal and Neonatal Healthcare
- Heavy metals in environment
- Frailty in Older Adults
- Reproductive tract infections research
- Geriatric Care and Nursing Homes
- COVID-19 and Mental Health
- Healthcare and Environmental Waste Management
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
Jain University
2025
Centers for Disease Control and Prevention
2016-2024
National Center for Immunization and Respiratory Diseases
2018-2022
United States Department of Health and Human Services
2020
Epidemic Intelligence Service
2016-2018
Administration for Children and Families
2016
Health and Human Services Agency
2016
National Center for Health Statistics
2016
<h3>Importance</h3> Invasive disease owing to group B<i>Streptococcus</i>(GBS) remains an important cause of illness and death among infants younger than 90 days in the United States, despite declines early-onset (EOD; with onset at 0-6 life) that are attributed intrapartum antibiotic prophylaxis (IAP). Maternal vaccines prevent infant GBS currently under development. <h3>Objective</h3> To describe incidence rates, case characteristics, antimicrobial resistance, serotype distribution EOD...
Nursing home and long-term care facility residents live in congregate settings are often elderly frail, putting them at high risk for infection with SARS-CoV-2, the virus that causes COVID-19, severe COVID-19-associated outcomes; therefore, this population was prioritized early vaccination United States (1). Following rapid distribution administration of mRNA COVID-19 vaccines (Pfizer-BioNTech Moderna) under an Emergency Use Authorization by Food Drug Administration (2), observational...
This report describes an analysis of two Connecticut skilled nursing facilities that found partial vaccination, >14 days after the first dose through 7 second dose, with Pfizer-BioNTech COVID-19 vaccine 63% effective against SARS-CoV-2 infection.
Two near-identical clinical Streptococcus pyogenes isolates of emm subtype emm43.4 with a pbp2x missense mutation (T553K) were detected. Minimum inhibitory concentrations (MICs) for ampicillin and amoxicillin 8-fold higher, the MIC cefotaxime was 3-fold higher than near-isogenic control isolates, consistent first step in developing β-lactam resistance.
Nursing home residents have experienced disproportionally high levels of COVID-19-associated morbidity and mortality were prioritized for early COVID-19 vaccination (1). Following reported declines in vaccine-induced immunity after primary series vaccination, defined as receipt 2 doses an mRNA vaccine (BNT162b2 [Pfizer-BioNTech] or mRNA-1273 [Moderna]) 1 dose Ad26.COV2 (Johnson & Johnson [Janssen]) (2), CDC recommended that all persons aged ≥12 years receive a booster dose.* Moderately to...
Abstract Background Descriptions of changes in invasive bacterial disease (IBD) epidemiology during the coronavirus 2019 (COVID-19) pandemic United States are limited. Methods We investigated incidence IBD due to Streptococcus pneumoniae, Haemophilus influenzae, group A (GAS), and B (GBS). defined COVID-19 period as 1 March 31 December 2020. compared observed incidences expected incidences, consistent with January 2014 February 2020 trends. conducted secondary analysis a health care database...
Abstract Background Treatment of severe group A Streptococcus (GAS) infections requires timely and appropriate antibiotic therapy. We describe the epidemiology antimicrobial-resistant invasive GAS (iGAS) in United States (US). Methods analyzed population-based iGAS surveillance data at 10 US sites from 2006 through 2017. Cases were defined as infection with isolated normally sterile or wounds patients necrotizing fasciitis streptococcal toxic shock syndrome. isolates emm typed. Antimicrobial...
Background Streptococcus pyogenes is a major cause of severe, invasive infections in humans. The bacterial pathogen harbors wide array virulence factors and exhibits high genomic diversity. Rapid changes circulating strains community are common. Understanding the current prevalence dynamics S. lineages could inform vaccine development disease control strategies. Methods We used whole-genome sequencing (WGS) to characterize all isolates obtained through Center for Disease Control Prevention's...
Abstract We analyzed 9630 invasive GAS surveillance isolates in the USA. From 2015–2017 to 2018–2019, significant increases erythromycin-nonsusceptibility (18% vs 25%) and clindamycin-nonsusceptibility (17% 24%) occurred, driven by rapid expansions of genomic subclones. Prevention control clustered infections appear key containing antimicrobial resistance.
Abstract Background Group A streptococci (GAS), although usually responsible for mild infections, can sometimes spread into normally sterile sites and cause invasive GAS disease (iGAS). Because both the risk of iGAS occurrence outbreaks are elevated within certain communities, such as those comprising people who inject drugs (PWID) experiencing homelessness (PEH), understanding transmission dynamics is major relevance to public health. Methods We used a cluster detection tool scan genomes...
During March 4-August 11, 2016, 25 outbreak-associated cases of meningococcal disease, including two deaths (8% case-fatality ratio), were reported in Southern California. Twenty-four the caused by serogroup C Neisseria meningitidis (NmC) and one N. with an undetermined (Figure). On June 24, response to this increase NmC cases, primarily among men who have sex (MSM) Los Angeles County, city Long Beach, Orange California Department Public Health (CDPH) issued a press release health advisory,...
Abstract A healthcare-associated group Streptococcus outbreak involving six patients, four healthcare workers, and one household contact occurred in the labor delivery unit of an academic medical center. Isolates were highly related by whole genome sequencing. Infection prevention measures, worker screening, chemoprophylaxis those colonized halted further transmission.
Abstract Background The genomic features and transmission link of circulating Group A Streptococcus (GAS) strains causing different disease types, such as pharyngitis invasive disease, are not well understood. Methods We used whole-genome sequencing to characterize GAS isolates recovered from persons with in the Denver metropolitan area June 2016 April 2017. Results were cultured 236 417 infections. Whole-genome identified 34 emm types. Compared isolates, more likely carry erm family genes...
ObjectiveTo evaluate if facility-level vaccination after an initial clinic was independently associated with COVID-19 incidence adjusted for other factors in January 2021 among nursing home residents.DesignEcological analysis of data from the CDC's National Healthcare Safety Network (NHSN) and Pharmacy Partnership Long-Term Care Program.Setting ParticipantsCMS-certified homes participating both NHSN Program.MethodsA multivariable, random intercepts, negative binomial model applied to...
Abstract Background Pneumococcal conjugate vaccine (PCV13) was recommended in series with PPSV23 for all US adults ≥65 years late 2014. We evaluated effectiveness of PCV13 against invasive pneumococcal disease (IPD) among Medicare beneficiaries old to assess this new policy. Methods linked records IPD cases (pneumococcus isolated from sterile sites) persons identified through Active Bacterial Core surveillance those beneficiaries. Isolates were serotyped and classified as (with or without...
In 2014, an acute respiratory illness outbreak affected unaccompanied children from Central America entering the United States; 9% of 774 surveyed were colonized with Streptococcus pneumoniae serotype 5. our 2015 follow-up survey 475 children, 5 was not detected, and interim recommendation to administer 13-valent pneumococcal conjugate vaccine all discontinued.
Routine surveillance for streptococcal toxic shock syndrome (STSS), a severe manifestation of invasive group A Streptococcus (GAS) infections, likely underestimates its true incidence. The objective our study was to evaluate routine identification STSS in national system GAS infections.Active Bacterial Core (ABCs) conducts active population-based disease selected US counties 10 states. We categorized cases with diagnosis made by physician as STSS-physician and that met the Council State...