A5101696312- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Respiratory Support and Mechanisms
- Infectious Aortic and Vascular Conditions
- Streptococcal Infections and Treatments
- Pharmacological Effects of Natural Compounds
- Antimicrobial Resistance in Staphylococcus
- Neonatal Respiratory Health Research
- Alzheimer's disease research and treatments
- Neonatal and Maternal Infections
- Computational Drug Discovery Methods
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Ovarian function and disorders
- Pain Mechanisms and Treatments
- Tracheal and airway disorders
- Vasculitis and related conditions
- Ion Channels and Receptors
- Macrophage Migration Inhibitory Factor
- Gastric Cancer Management and Outcomes
- Natural product bioactivities and synthesis
- Nanoplatforms for cancer theranostics
- Food Allergy and Anaphylaxis Research
- Female Genital Mutilation/Cutting Issues
- Inflammatory Myopathies and Dermatomyositis
China Medical University
2025
First Hospital of China Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2024
Second Hospital of Shanxi Medical University
2024
Shanxi Medical University
2014-2024
Centers for Disease Control and Prevention
2020-2023
Institute of Hematology & Blood Diseases Hospital
2023
Peking Union Medical College Hospital
2012-2022
University of South China
2022
Changsha Central Hospital
2022
Abdominal aortic aneurysm (AAA) is the full thickness dilation of abdominal aorta. However, few effective medical therapies are available. Thus, elucidating molecular mechanism AAA pathogenesis and exploring potential target for vital importance.Three expression datasets (GSE7084, GSE47472 GSE57691) were downloaded from Gene Expression Omnibus (GEO). These merged then normalized using "sva" R package. Differential expressed gene (DEG) analysis weighted co-expression network (WGCNA)...
Abstract Aggregation‐caused fluorescence quenching with insufficient production of reactive oxygen species (ROS) has limited the application photosensitizers (PSs) in fluorescence‐imaging‐guided photodynamic therapy (PDT). Aggregation‐induced emission PSs (AIE‐PSs) exhibit enhanced intensity and a high efficiency ROS generation aggregation state, which provides an opportunity to solve above problems. Herein, series AIE‐PSs are successfully designed synthesized by adjusting D–A through...
From 2015-2018 to 2019‒2021, hypertoxigenic M1UK lineage among invasive group A Streptococcus increased in the United States (1.7%, 21/1,230 11%, 65/603; p<0.001). was observed 9 of 10 states, concentrated Georgia (n = 41), Tennessee 13), and New York 13). Genomic cluster analysis indicated recent expansions.
Intestinal microecology plays an important role in the development and progression of hematological malignancies. However, characteristics gut microbiota diffuse large B cell lymphoma (DLBCL) have not been reported. The composition fecal samples from 25 untreated DLBCL patients 26 healthy volunteers was examined by 16S rRNA gene sequencing. On α-diversity analysis, there no significant difference species diversity abundance between two groups. a observed on β-diversity analysis. intestinal...
Abstract Osteoarthritis (OA) is a degenerative joint disease characterised by inflammation and cartilage degeneration. Ellagic acid (EA) might have therapeutic potential in OA, but its molecular mechanisms of action remain unclear. In this study, we aimed to identify the docking protein EA M1 macrophage‐related pro‐inflammation OA. Bioinformatics analysis was performed ellagic acid's targets among OA‐related dysregulated genes. THP‐1 cells were induced into M0 polarised macrophages for vitro...
Ulcerative colitis (UC) is a chronic condition in which the overreacting immune system may play an important role. It has been confirmed that interleukin (IL) 9 (IL-9) participates pathogenesis of UC but molecular mechanism not fully illustrated. Here, we show levels peripheral blood cytokines IL-9, IL-8, IL-10, IL-6, IL-1β, IL-12, and tumor necrosis factor (TNF) were higher patients with than normal control, serum local IL-9 positively correlated disease activity grade. Moreover,...
The root of Astragalus membranaceus var. mongholicus is one the most popular herbal medicines worldwide. In order to increase yield underground roots A. mongholicus, its flowers (AMF) have often been removed in their flowering stage, which produces as waste being discarded. To explore phytochemicals and potential value for utilization, antioxidant activities extracts from AMF were evaluated by a free radical scavenging assay reducing power assay. total phenols flavonoids, well individual...
Neuropathic pain (NP) represents a debilitating and refractory condition. However, the understanding of NP current treatment approaches available for its management are limited. Therefore, there is significant need to address dearth effective therapeutic interventions. This study aims investigate regulation transient receptor potential vanilloid 1 (TRPV1) cyclin-dependent kinase 5 (CDK5) expression levels by miR-142-5p as common upstream molecule, delve into mature process from perspective...
Inheritance of the apolipoprotein E genotype ε4 (APOE4) is a powerful risk factor for most cases late-onset Alzheimer's disease (AD). However, effects ApoE4 on long-term synaptic plasticity and its underlying mechanism have not clearly
A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. Most the tested compounds exhibited high AChE inhibition low toxicity, among which 1, 2, 10 most potent (IC50 = 71.52 ± 22.43, 8.28 1.45, 5.830 1.78 nm, respectively).
Abstract Background The genomic features and transmission link of circulating Group A Streptococcus (GAS) strains causing different disease types, such as pharyngitis invasive disease, are not well understood. Methods We used whole-genome sequencing to characterize GAS isolates recovered from persons with in the Denver metropolitan area June 2016 April 2017. Results were cultured 236 417 infections. Whole-genome identified 34 emm types. Compared isolates, more likely carry erm family genes...
Background Eltrombopag (EPAG), an oral thrombopoietin receptor agonist (TPO-RA), has been proven to improve the hematologic response without increasing toxic effects as a first-line therapy combined with standard immunosuppressive treatment (IST) in adults severe aplastic anemia (SAA). Nevertheless, clinical evidence on efficacy of EPAG children acquired is limited and controversial. Methods We performed single-center, retrospective study analyze outcomes fifteen patients aged ≤18 years...
Idiopathic inflammatory myopathies (IIMs) are autoimmune diseases influenced by genetic background and environmental factors. Recently, FAM167A-BLK gene has been identified as a potential susceptibility locus for dermatomyositis (DM) in patients of European Japanese populations. Our aim here was to investigate the association between polymorphisms IIMs risk Chinese Han. The single nucleotide (SNPs) rs2736340, rs7812879, rs13277113, rs2618479, rs2254546 rs2248932 were analyzed polymyositis...
Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unclear pathogenesis. A recent genome-wide association study (GWAS) has revealed that the FCGR2A/FCGR3A, EEFSEC, RPS9/LILRB3, RIPPLY2 and MLX genes confer susceptibility to TA. We investigated linkage between presumptive TA-related (FCGR2A/FCGR3A, MLX) TA in Han Chinese population.We performed large case-control multi-center 412 patients 597 ethnically matched healthy controls. Five single nucleotide polymorphisms (SNPs) were...
Ten new resorcinol derivatives named hansfordiols A - J (1 10) were isolated from the fermentation broth of sponge-derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT-IR spectroscopy, and NMR techniques used to elucidate structures these compounds, absolute configurations established by modified Mosher's method their specific optical rotation. The compounds 8 10 featured with various chlorination at aromatic rings. Their antioxidant activities on...