A5100722581- Urologic and reproductive health conditions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Prostate Cancer Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Acupuncture Treatment Research Studies
- Neuropeptides and Animal Physiology
- Testicular diseases and treatments
- Prostate Cancer Treatment and Research
- Hearing Loss and Rehabilitation
- Cardiovascular Health and Risk Factors
- Nutrition, Genetics, and Disease
- Pregnancy-related medical research
- Gut microbiota and health
- Hearing, Cochlea, Tinnitus, Genetics
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Cytokine Signaling Pathways and Interactions
- Abdominal Surgery and Complications
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Reproductive tract infections research
- Hernia repair and management
Fujian University of Traditional Chinese Medicine
2017-2025
Fuyang Normal University
2024-2025
South China University of Technology
2023-2025
Guangzhou Medical University
2023-2024
Southwest Medical University
2024
Affiliated Hospital of Southwest Medical University
2024
Chengdu Fifth People's Hospital
2023-2024
Chengdu University of Traditional Chinese Medicine
2023-2024
Geisinger Health System
2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2011-2024
IMPORTANCE Noncommunicable chronic diseases have become the leading causes of mortality and disease burden worldwide.OBJECTIVE To investigate prevalence diabetes glycemic control in Chinese adult population.DESIGN, SETTING, AND PARTICIPANTS Using a complex, multistage, probability sampling design, we conducted cross-sectional survey nationally representative sample 98 658 adults 2010.MAIN OUTCOMES MEASURES Plasma glucose hemoglobin A 1c levels were measured after at least 10-hour overnight...
BackgroundVision loss is an important public health issue in China, but a detailed understanding of national and regional trends its prevalence causes, which could inform policy, has not been available. This study aimed to assess the prevalence, distribution vision impairment blindness China 1990 2019.MethodsData from Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019 were used estimate moderate severe compare with other Group 20 (G20) countries. We GBD methodology...
Abstract Antipsychotic drugs regulate gene transcription in striatal neurons by blocking dopamine D 2 ‐like receptors. Little is known about the underlying changes chromatin structure, including covalent modifications at histone N‐terminal tails that are epigenetic regulators of expression. We show treatment with antagonists rapidly induces phosphorylation H3 serine 10 and acetylation H3‐lysine 14 bulk from striatum nuclei neurons. find that, vivo , antagonist‐induced phospho‐acetylation...
Abstract Glaucoma is not only an eye disease but also associated with degeneration of brain structures. We now investigated the pattern visual and non-visual structural changes in 25 primary open angle glaucoma (POAG) patients age-gender-matched normal controls using T1-weighted imaging. MRI images were subjected to volume-based analysis (VBA) surface-based (SBA) whole as well ROI-based lateral geniculate nucleus (LGN), cortex (V1/2), amygdala hippocampus. While VBA showed no significant...
Purpose To compare standard diffusion-weighted (DW) imaging and diffusion kurtosis (DK) for prostate cancer (PC) detection characterization in a large patient cohort, with attention to the potential added value of DK imaging. Materials Methods This retrospective institutional review board-approved study received waiver informed consent. Two hundred eighty-five patients PC underwent 3.0-T phased-array coil magnetic resonance (MR) imaging, including sequence (b values 0, 500, 1000, 1500, 2000...
Abstract Background In China, few studies have examined the relationship between combination of body mass index and waist circumference risk stroke. Moreover, may also be different in genders. Thus, we investigated association stroke Chinese. Methods This prospective cohort study included 36 632 participants aged 18 to 90 years. Participants were recruited from 60 surveillance sites (25 urban 35 rural sites) across China 2010 Chronic Disease Risk Factor Surveillance, followed up 2016-2017....
Psoriasis is a chronic, recurrent, immune-mediated inflammatory skin disease characterized by erythematous scaly lesions. Obesity currently major global health concern, increasing the risk of diseases such as cardiovascular and diabetes. Since correlation between psoriasis obesity, well hypertension, diabetes, diseases, has been clinically evidenced, it certain clinical significance to explore mechanisms underlying comorbidity with these conditions.
Atypical intraductal cribriform proliferations of the prostate (AIP) are loose luminal cells that exhibit greater architectural complexity and/or nuclear atypia than high-grade prostatic intraepithelial neoplasia (HGPIN), but lack diagnostic criteria for carcinoma (IDC). The significance AIP has not been formally established. We compared clinical, morphologic, and immunohistochemical characteristics with classic IDC in 310 radical prostatectomy specimens were received over an 18-month...
Current studies in most Western countries have largely focused on body mass index (BMI) as an important risk factor for impaired glucose tolerance (IGT) and fasting (IFG), which different pathophysiological bases. In people with obesity, the prevalence of IGT is higher IFG lower. The Asian population than that white population, obesity rate China still increasing. However, few cohort explore relationship between BMI incidence China. We aimed to Chinese adults analyze differences them.
Vaccinia virus replication is inhibited by etoposide and mitoxantrone even though poxviruses do not encode the type II topoisomerases that are specific targets of these drugs. Furthermore, one can isolate drug-resistant carrying mutations in viral DNA ligase yet known to exhibit sensitivity A yeast two-hybrid screen was used search for proteins binding vaccinia ligase, nine identified comprised a portion (residue 901 end) human topoisomerase IIbeta. One prevent interaction introducing...
Ulcerative colitis (UC) is a chronic condition in which the overreacting immune system may play an important role. It has been confirmed that interleukin (IL) 9 (IL-9) participates pathogenesis of UC but molecular mechanism not fully illustrated. Here, we show levels peripheral blood cytokines IL-9, IL-8, IL-10, IL-6, IL-1β, IL-12, and tumor necrosis factor (TNF) were higher patients with than normal control, serum local IL-9 positively correlated disease activity grade. Moreover,...
Developing noble-metal-based catalysts with ultralow loading to achieve excellent performance for selective hydrogenation of alkynes under mild reaction conditions is highly desirable but still faces huge challenges. To this end, a SO3H-anchored covalent organic framework (COF-SO3H) as the support was deliberately designed, and then ultralow-content Pd (0.38 wt %) loaded by wet-chemistry immersion dispersion method. The resulting Pd0.38/COF-SO3H composite exhibits outstanding phenylacetylene...
To explore the effect of electro-acupuncture (EA) treatment on pattern separation and investigate neural circuit mechanism involved in five familial mutations (5 × FAD) mice.Five mice were treated with EA at Baihui (DU20) Shenting (DU24) acupoints for 30 min each, lasting 4 weeks. Cognitive-behavioral tests performed to evaluate effects cognitive functions. 1H-MRS, Nissl staining, immunohistochemistry, immunofluorescence examine cholinergic system alteration. Thioflavin S staining 6E10...
Background/Objectives: Patients with glaucoma often exhibit cognitive dysfunction. Identifying imaging markers of glaucoma-related dysfunction can guide early clinical interventions. Method: This study included 44 primary angle-closure patients (PACG) dysfunction, and 46 healthy controls (HCs). Participants underwent 3D high-resolution T1 structural BOLD fMRI scanning. Seven hippocampus subregions were selected as seed regions to explore changes in functional connectivity (FC) between the...
Psoriasis is a chronic inflammatory disorder for which phosphodiesterase-4 (PDE4) inhibitors have emerged as promising therapeutic agents due to an ability regulate signaling pathways. In this study 1200 methanolic extracts from Chinese medicinal plants were screened and Eclipta prostrata (L.) Linn. ( E. ) was shown potent PDE4 inhibitory activity. Bioassay-guided fractionation further demonstrated that the ethyl acetate (EA) fraction exhibited highest activity, leading isolation of...
With industrial development, endocrine-disrupting chemicals have continued to accumulate in the environment, attracting growing attention due their potential effects on biological health. The reproductive toxicity of diethylstilbestrol (DES), a synthetic estrogen widely present is documented; however, studies its immune system remain limited. In this study, adult male golden hamsters were subcutaneously administered varying doses DES (0, 0.01, 0.1, and 1.0 mg/kg) for seven consecutive days...
There is an increasing frequency of requests for cochlear implantation (CI) in deaf children and more detailed image information necessary selecting appropriate candidates. Cochlear nerve deficiency (CND) a contraindication to CI. Magnetic resonance imaging (MRI) has been used evaluate the integrity nerve. The abnormalities canal (CNC) internal auditory (IAC) have reported be associated with CND.To correlate CNC manifestation, size, IAC diameter on high-resolution CT (HRCT) CND diagnosed by...