A5100782523- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Microbial Natural Products and Biosynthesis
- Evaluation and Optimization Models
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Ovarian cancer diagnosis and treatment
- Ear Surgery and Otitis Media
- Evaluation Methods in Various Fields
- Autophagy in Disease and Therapy
- Marine Sponges and Natural Products
- Immune cells in cancer
- interferon and immune responses
- IL-33, ST2, and ILC Pathways
- Nuclear Receptors and Signaling
- Apelin-related biomedical research
- Tea Polyphenols and Effects
- Nasal Surgery and Airway Studies
- Immunotoxicology and immune responses
- Berberine and alkaloids research
- Endometriosis Research and Treatment
- Lipid metabolism and disorders
Yangzhou University
2022-2025
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
South China University of Technology
2022-2024
Guangdong Academy of Medical Sciences
2024
Jinan University
2015-2023
Gaochun People's Hospital
2018-2023
Sichuan University
2018-2022
First Affiliated Hospital of Jinan University
2022
West China Hospital of Sichuan University
2018-2022
Regulatory T (Treg) cells are critical in shaping an immunosuppressive microenvironment to favor tumor progression and resistance therapies. However, the heterogeneity function of Treg esophageal squamous cell carcinoma (ESCC) remain underexplored. We identified CD177 as a tumor-infiltrating marker ESCC. Interestingly, expression levels PD-1 were mutually exclusive cells.
The precancerous disease of breast cancer is an inevitable stage in the tumorigenesis and development neoplasms. Quercetin (Que) has shown great potential treatment by inhibiting cell proliferation regulating T function. γδ cells are a class nontraditional that have long attracted attention due to their immunotherapy. In this study, we revealed immunomodulatory function Que through regulation JAK/STAT1 signaling pathway, which was followed synergistic killing cells.In experimental design,...
Abstract Kaempferol has been suggested to be an effective anticancer agent in several malignant tumors. However, its function and mechanisms breast precancerous lesions remain largely elusive. Here, we showed that kaempferol induced excessive mitochondrial fission damage with activated factor (MFF)‐mediated dynamin‐related protein (DRP) 1 translocation. As a result, the PTEN‐induced putative kinase (PINK1)/Parkin signaling pathway was activated, accompanied by mitophagy reduced mass cells....
A peroxidase mimic was firstly fabricated using a covalent assembly strategy, which can be used for highly sensitive glucose detection.
Interferon-α (IFN-α) is an adjuvant to chemotherapy and radiotherapy for hepatocellular carcinoma (HCC), but some HCC patients do not respond treatment with IFN-α.We performed loss-of-function gain-of-function experiments examine the role of ISG15 in IFN-α sensitivity LH86, HLCZ01, SMMC7721, Huh7 cell lines tumor samples.The overexpression reduced apoptosis LH86 cells presence IFN-α, whereas shRNA-mediated knock down expression increased both cells. We identified a putative miR-370 target...
BACKGROUND Osteoarthritis (OA) is a joint disease characterized by articular cartilage degeneration and inflammation. We have previously clarified that xanthan gum (XG) preparation exerts ameliorating effect on rabbit OA model regulating matrix metalloproteinase (MMP)-1 MMP-3, which are critical proteins in the Wnt3a/ß-catenin pathway. Thus, it reasonable to predict pathway involved treatment of with XG. MATERIAL AND METHODS The XG animals were observed hematoxylin eosin staining (HE),...
Primary biliary cholangitis (PBC) is a cholestatic liver disease primarily featured by autoimmune-mediated damage of intrahepatic small- and medium-sized bile ducts. Elevated serum proinflammatory cytokines, anti-mitochondrial antibodies (AMAs), inflammation, fibrosis are also hallmarks PBC disease. However, whether the elevated cytokines play role in autoimmune remains unknown. Herein, we utilized p40-/-IL-2Rα -/- mouse model to investigate roles IL-18, IL-21, IFN-γ onset progression PBC....
Abstract In late 2020, we detected 32 highly pathogenic avian influenza A(H5N8) viruses in migratory ducks Shanghai, China. Phylogenetic analysis of 5 representative isolates identified 2 sublineages clade 2.3.4.4b. Each sublineage formed separate clusters with from East Asia and Europe.
Ten new resorcinol derivatives named hansfordiols A - J (1 10) were isolated from the fermentation broth of sponge-derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT-IR spectroscopy, and NMR techniques used to elucidate structures these compounds, absolute configurations established by modified Mosher's method their specific optical rotation. The compounds 8 10 featured with various chlorination at aromatic rings. Their antioxidant activities on...
Cervical cancer (CC) is one of the main causes death among gynecological malignancies. Patients with CC lymph node metastasis (LNM) have poor prognoses. We investigated risk factors and prognosis LNM in patients using data from SEER database.We collected information cervical registered database 2010 to 2015. The dataset was divided into a training set validation at 7:3 ratio. LASSO regression analysis used evaluate for CC. Using results, we established nomogram prediction model. C-index, ROC...
Summary In this study, we investigated the biological activities of a novel berberine‐metformin hybrid compound ( BMH 473) as an anti‐diabetic agent. 473 exhibited significant anti‐hyperglycaemic and anti‐hyperlipidaemic effects on T2 DM rats. white adipose tissue, reduced perirenal epididymal tissue mass modulated lesions in by inhibiting protein expressions PPAR ‐Ɣ, C/ EBP ‐α SREBP ‐1c well mRNA lipogenic genes. Moreover, downregulated levels pro‐inflammatory cytokines through suppression...
Purpose: The prognosis of patients with intermediate-stage hepatocellular carcinoma (HCC) treated by conventional TACE (cTACE) is greatly heterogeneous. This study aimed to develop a new survival prediction model help select who would benefit better from cTACE treatment. Methods: We collected data 848 treatment-naïve BCLC B HCC received as first-line therapy. prognostic model's variables were derived univariate and multivariate Cox regression analyses. concordance index (C-statistic)...