Martin Keszler
A5049339467- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Neonatal and fetal brain pathology
- Infant Nutrition and Health
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Combustion and Detonation Processes
- Birth, Development, and Health
- Child and Adolescent Health
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Pediatric Pain Management Techniques
- Neonatal Health and Biochemistry
- Nuclear Engineering Thermal-Hydraulics
- Plasma and Flow Control in Aerodynamics
- Assisted Reproductive Technology and Twin Pregnancy
- Family and Patient Care in Intensive Care Units
- Transplantation: Methods and Outcomes
Brown University
2016-2025
Guangzhou Medical University
2025
Guangzhou Women and Children Medical Center
2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2021-2025
Research Network (United States)
2017-2025
Women & Infants Hospital of Rhode Island
2016-2025
Health and Human Development (2HD) Research Network
2023-2025
Clinical Trial Investigators
2024
Providence College
2011-2022
Pediatrics and Genetics
2009-2021
Current diagnostic criteria for bronchopulmonary dysplasia rely heavily on the level and duration of oxygen therapy, do not reflect contemporary neonatal care, adequately predict childhood morbidity.
Inhaled nitric oxide improves gas exchange in neonates, but the efficacy of low-dose inhaled reducing need for extracorporeal membrane oxygenation has not been established.
Despite improvement during recent decades, extremely preterm infants continue to contribute disproportionately neonatal mortality and childhood morbidity. To review survival, in-hospital morbidities, care practices, neurodevelopmental functional outcomes at 22-26 months' corrected age for infants. Prospective registry born 19 US academic centers that are part of the Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. The study included 10 877...
<h3>Importance</h3> Preterm infants must establish regular respirations at delivery. Sustained inflations may lung volume faster than short inflations. <h3>Objective</h3> To determine whether a ventilation strategy including sustained inflations, compared with standard intermittent positive pressure ventilation, reduces bronchopulmonary dysplasia (BPD) or death 36 weeks' postmenstrual age without harm in extremely preterm infants. <h3>Design, Setting, and Participants</h3> Unmasked,...
Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment the second postnatal week can improve survival without bronchopulmonary and adverse neurodevelopmental effects unknown. We conducted trial involving infants who had gestational age of less than 30 weeks been intubated for at least 7 days 14 28 days. Infants were randomly assigned receive either (4 mg...
Importance Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared formula. For receiving no or minimal maternal milk, it is unknown whether donor human conveys similar advantages vs Objective To determine if nutrient-fortified, pasteurized improves at 22 to 26 months’ corrected age infant formula among who received milk. Design, Setting, and Participants Double-blind, randomized clinical trial...
Importance Hypothermia begun less than 6 hours after birth reduces death or disability in infants with encephalopathy due to hypoxia-ischemia at 36 more weeks’ gestation. Trials of hypothermia for younger gestation are lacking. Objective To assess the probability that decreases 33 35 moderate severe hypoxic-ischemic encephalopathy. Design, Setting, and Participants This randomized clinical trial was conducted between July 2015 December 2022 birth. Bayesian intention-to-treat analyses were...
Objective. Infants with meconium aspiration syndrome (MAS) have marked surfactant dysfunction. Airways and alveoli of affected neonates contain meconium, inflammatory cells, mediators, edema fluid, protein, other debris. The objective this study was to compare treatment bronchoalveolar lavage using dilute Surfaxin standard therapy in a population newborn infants MAS. Methods. Inclusion criteria were 1) gestational age ≥35 weeks, 2) enrollment within 72 hours birth, 3) diagnosis MAS, 4) need...
Persistent pulmonary hypertension of the newborn (PPHN) is often secondary to parenchymal lung disease (such as meconium aspiration syndrome) or hypoplasia (with congenital diaphragmatic hernia) but can also be idiopathic. PPHN characterized by elevated vascular resistance, resulting in right-to-left shunting blood and hypoxemia. The diagnosis based on clinical evidence labile hypoxemia associated with differential cyanosis confirmed echocardiography. Lung volume recruitment optimal use...
Importance Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are adverse neurologic outcomes low-risk infants. Whether this association exists contemporary practice is uncertain because most randomized clinical trials administered earlier and higher doses than currently recommended. Objective To evaluate whether the pretreatment death or grade 2 3 BPD 36 weeks’...
Inguinal hernia repair in preterm infants is common and associated with considerable morbidity. Whether the inguinal should be repaired prior to or after discharge from neonatal intensive care unit controversial. To evaluate safety of early vs late surgical for an hernia. A multicenter randomized clinical trial including diagnosed during initial hospitalization was conducted between September 2013 April 2021 at 39 US hospitals. Follow-up completed on January 3, 2023. In strategy, underwent...
Objective. To test the hypothesis that high-frequency jet ventilation (HFJV) will reduce incidence and/or severity of bronchopulmonary dysplasia (BPD) and acute airleak in premature infants who, despite surfactant administration, require mechanical for respiratory distress syndrome. Design. Multicenter, randomized, controlled clinical trial HFJV conventional (CV). Patients were to remain on assigned therapy 14 days or until extubation, whichever came first. Crossover from CV was allowed if...
Objective. To compare the transfusion practices between two neonatal intensive care units (NICUs) to assess impact of local practice styles on timing, number, and total volume packed red cell transfusions in very low birth weight infants. derive multivariate models describe identify potential areas for improvement future. Methodology. We reviewed phlebotomy losses rates NICUs (A B) 270 consecutive admissions &lt;1500 g. stratified illness severity by Score Neonatal Acute Physiology...
Abstract Excessive tidal volume (V T ) can lead to lung injury, hypocarbia, and neurologic damage. Volume guarantee (VG) uses exhaled V as the control variable reduce risk of volutrauma more closely PaCO 2 . Our objective was test hypothesis that VG combined with assist/control (A/C) will maintain within target range consistently than alone during first 72 hr life in ventilated preterm infants. Eligible infants were randomly assigned A/C + or alone. Data recorded directly from pressure...
<h3>Objective</h3> To determine periextubation practices in extremely preterm infants (<28 weeks gestation). <h3>Design</h3> A survey consisting of 13 questions related to weaning from mechanical ventilation, assessment extubation readiness and postextubation respiratory support was developed sent clinical directors level III NICUs Australia, Canada, Ireland, New Zealand USA. descriptive analysis the results performed. <h3>Results</h3> 112/162 (69%) units responded; 36% reported having a...