A5082432417- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Pulmonary Hypertension Research and Treatments
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Prenatal Substance Exposure Effects
- Infant Nutrition and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Congenital Heart Disease Studies
- Breastfeeding Practices and Influences
- Gut microbiota and health
- Cardiac Arrest and Resuscitation
- Retinopathy of Prematurity Studies
- Neuropeptides and Animal Physiology
- Pediatric health and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Congenital Anomalies and Fetal Surgery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Assisted Reproductive Technology and Twin Pregnancy
- Respiratory viral infections research
- Cardiovascular Conditions and Treatments
- Non-Invasive Vital Sign Monitoring
University of Alabama at Birmingham
2018-2025
Yale University
2024-2025
Health and Human Development (2HD) Research Network
2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2025
Research Network (United States)
2025
Pediatrics and Genetics
2022
University of Warwick
1996
Importance Hypothermia begun less than 6 hours after birth reduces death or disability in infants with encephalopathy due to hypoxia-ischemia at 36 more weeks’ gestation. Trials of hypothermia for younger gestation are lacking. Objective To assess the probability that decreases 33 35 moderate severe hypoxic-ischemic encephalopathy. Design, Setting, and Participants This randomized clinical trial was conducted between July 2015 December 2022 birth. Bayesian intention-to-treat analyses were...
Background: Extremely preterm infants with evolving bronchopulmonary dysplasia (BPD) are at risk for development of BPD-associated pulmonary hypertension (BPD-PH). The presence and duration a patent ductus arteriosus (PDA) shunt may be modifiable factor BPD-PH development. Methods: Retrospective case-control study among 22w 0d to 28w 6d who remained on respiratory support postnatal day 28 the University Alabama Birmingham from 2017-2020. Infants were diagnosed (cases) by echocardiography...
Rationale: Bedside biomarkers that allow early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) are critically important, given the higher risk death in these infants. Objectives: We hypothesized BPD-PH have patterns intermittent hypoxemia (IH) differ from BPD without PH. Methods: conducted a matched case-control study extremely preterm 22 weeks 0 days to 28 6 born between 2018 and 2020 at University Alabama Birmingham. status was...
To test the hypothesis that socioeconomic deprivation is associated with an increased risk of admission clinically suspected bronchiolitis.Case-control study.Children under 1 year living in Sheffield 1989-90.307 children resident admitted to hospitals bronchiolitis between October 1989 and 28 February 1990.Children were ascertained from laboratory records nasopharyngeal aspirates cultured for respiratory syncytial virus. Case notes examined determine whether these had required medical...
To test the primary hypothesis that extremely preterm children antenatally exposed to both magnesium sulfate and antenatal corticosteroids have a lower rate of severe neurodevelopmental impairment or death compared with those alone.This was prospective observational study born at 22 0/7-26 6/7 weeks gestation from 2011 2014 Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network hospitals (N=3,093). The outcome 18-26 months corrected age follow-up...
Importance When preterm delivery is imminent, it remains unclear whether the timing from administration of antenatal betamethasone to birth may reduce mortality and morbidity among extremely infants. Objective To evaluate association duration exposure first dose with outcomes Design, Setting, Participants This cohort study enrolled infants born at 22 0/7 27 6/7 weeks’ gestation January 2016 February 2021 National Institute Child Health Human Development Neonatal Research Network centers....
Hospitalization of moderately preterm infants may be prolonged while waiting for apnea prematurity to resolve after discontinuing caffeine. To evaluate whether extending caffeine treatment reduces the duration hospitalization. From February 2019 December 2022, this randomized clinical trial in 29 US hospitals enrolled born at 33 weeks' gestation who 35 postmenstrual age were receiving with plans discontinue it plus full feeds (≥120 mL/kg/d). Follow-up was completed on March 20, 2023. Infants...
OBJECTIVES Our objective with this quality improvement initiative was to reduce rates of severe intracranial hemorrhage (ICH) or death in the first week after birth among extremely preterm infants. METHODS The conducted from April 2014 September 2020 at University Alabama Birmingham’s NICU. All actively treated inborn infants without congenital anomalies 22 + 0/7 27 6/7 weeks’ gestation a weight ≥400 g were included. primary outcome ICH 7 days birth. Balancing measures included acute kidney...
Importance Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health Human Development Neonatal Research Network (NICHD NRN) Hydrocortisone Trial, hydrocortisone neither reduced rates BPD or death nor increased impairment (NDI) death. Objective To determine whether estimated grades 2 to 3 is associated with effect on composite outcomes (1) (2) moderate severe NDI...
The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity prematurity. While microbiota significantly influences neonatal health, relationship between intestinal microbiome, particularly micro-eukaryotic members such as fungi and yeast, injury severity in newborns remains unknown. Here, we show fungal modulates hyperoxia-induced low birth weight premature...
Introduction: We aimed to characterize features that can accurately identify preterm infants at risk of delay in oral feeding attainment. Methods: A prospective observational study born between 250/7 326/7 weeks’ gestation. Early independent feed attainment (EPO) was defined as within 35 days initiation and late (LPO) or after following initiation. Candidate characteristics comparison included interventions reasons for discontinuation. Results: Of the 257 included, 162 achieved EPO. Over...
Achievement of independent oral feedings remains the most common barrier to discharge in preterm infants. Early feeding initiation may be associated with a lower postmenstrual age (PMA) at and discharge. In infants born between 25 32 weeks' gestation, our aim was decrease PMA by 1 week June 2019 2020.Following formation multidisciplinary team, following plan-do-study-act cycles were targeted: (1) <33 PMA, (2) cue-based feeding, (3) practitioner-driven who had not yet achieved 36 PMA. Outcome...
Abstract Background MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate pathways of miR 219-5p important with Bronchopulmonary Dysplasia (BPD). Methods Here we report a prospective cohort study extremely neonates wherein diagnosed severe BPD expressed increased airway miR-219-5p and decreased platelet derived growth factor receptor alpha (PDGFR-α), target mir-219-5p key regulator...
Characterisation of oxygen saturation (SpO
The effects of muscarinic receptor antagonists on responses to electrical stimulation the chorda-lingual nerve were determined in pentobarbitone-anesthetized sheep and correlated morphology tissue specimens. Stimulation at 2 Hz continuously, or bursts 1 s 20 every 10 s, for min induced similar submandibular fluid (19 +/- 3 vs. 21 microl x min(-1) g gland(-1)), whereas vasodilatation was greater during (-52 4 -43 5%; P < 0.01). Continuous 8 substantially (66 9 gland(-1) -77 3%). While...
BACKGROUND AND OBJECTIVES: The challenge of identifying preterm infants with bronchopulmonary dysplasia (BPD) that need tracheostomy placement may delay goals care (GOC) discussions. By a low probability ventilation liberation, timely GOC discussions reduce the time to tracheostomy. Our SMART aim was postmenstrual age (PMA) by 20% in BPD and prolonged invasive ventilatory requirement October 2020. METHODS: group conducted quality improvement initiative at University Alabama Birmingham....