A5040294264- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Infant Nutrition and Health
- Prenatal Substance Exposure Effects
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Neonatal and Maternal Infections
- Maternal Mental Health During Pregnancy and Postpartum
- Child Nutrition and Water Access
- Gestational Diabetes Research and Management
- Respiratory Support and Mechanisms
- Neonatal Health and Biochemistry
- Cardiac Arrest and Resuscitation
- Child Nutrition and Feeding Issues
- Retinopathy of Prematurity Studies
- Breastfeeding Practices and Influences
- Anesthesia and Neurotoxicity Research
- Parkinson's Disease Mechanisms and Treatments
- Congenital Anomalies and Fetal Surgery
- Preterm Birth and Chorioamnionitis
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Bayesian Inference
RTI International
2016-2025
Nagaland University
2022-2025
Research Network (United States)
2007-2025
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2010-2025
Health and Human Development (2HD) Research Network
2010-2025
National Heart Lung and Blood Institute
2024
Emory University
2012-2024
Women & Infants Hospital of Rhode Island
2007-2023
Brown University
2007-2023
Cancer Research And Biostatistics
2014-2022
This report presents data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network on care morbidity mortality rates for very low birth weight infants, according to gestational age (GA). Perinatal/neonatal were collected 9575 infants extremely GA (22-28 weeks) (401-1500 g) who born at network centers between January 1, 2003, December 31, 2007. Rates survival discharge increased with increasing (6% 22 weeks 92% 28 weeks); 1060 died...
<h3>Importance</h3> Extremely preterm infants contribute disproportionately to neonatal morbidity and mortality. <h3>Objective</h3> To review 20-year trends in maternal/neonatal care, complications, mortality among extremely born at Neonatal Research Network centers. <h3>Design, Setting, Participants</h3> Prospective registry of 34 636 infants, 22 28 weeks' gestation, birth weight 401 1500 g, 26 network centers between 1993 2012. <h3>Exposures</h3> birth. <h3>Main Outcomes Measures</h3>...
BACKGROUND: Guidelines for prevention of group B streptococcal (GBS) infection have successfully reduced early onset (EO) GBS disease. Study results suggest that Escherichia coli is an important EO pathogen. OBJECTIVE: To determine rates, pathogens, morbidity, and mortality in a national network neonatal centers. METHODS: Infants with were identified by prospective surveillance at Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Network Infection was defined...
There are limited data to inform the choice between early treatment with continuous positive airway pressure (CPAP) and surfactant as initial support for extremely-low-birth-weight infants.
We previously reported early results of a randomized trial whole-body hypothermia for neonatal hypoxic–ischemic encephalopathy showing significant reduction in the rate death or moderate severe disability at 18 to 22 months age. Long-term outcomes are now available.
Understanding the causes and timing of death in extremely premature infants may guide research efforts inform counseling families. We analyzed prospectively collected data on 6075 deaths among 22,248 live births, with gestational ages 22 0/7 to 28 6/7 weeks, born study hospitals within National Institute Child Health Human Development Neonatal Research Network. compared overall cause-specific in-hospital mortality across three periods from 2000 through 2011, adjustment for baseline...
Between-hospital variation in outcomes among extremely preterm infants is largely unexplained and may reflect differences hospital practices regarding the initiation of active lifesaving treatment as compared with comfort care after birth. We studied born between April 2006 March 2011 at 24 hospitals included Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. Data were collected for 4987 before 27 weeks gestation without congenital anomalies....
Data reported during the past 5 years indicate that rates of survival have increased among infants born at borderline viability, but less is known about how these relate to early childhood neurodevelopmental outcomes. We compared and outcomes 22 24 weeks gestation, as assessed 18 months corrected age, across three consecutive birth-year epochs (2000-2003 [epoch 1], 2004-2007 2], 2008-2011 3]). The were 11 centers participated in National Institute Child Health Human Development Neonatal...
Despite improvement during recent decades, extremely preterm infants continue to contribute disproportionately neonatal mortality and childhood morbidity. To review survival, in-hospital morbidities, care practices, neurodevelopmental functional outcomes at 22-26 months' corrected age for infants. Prospective registry born 19 US academic centers that are part of the Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. The study included 10 877...
Benefits of identifying risk factors for bronchopulmonary dysplasia in extremely premature infants include providing prognostic information, likely to benefit from preventive strategies, and stratifying clinical trial enrollment.To identify dysplasia, the competing outcome death, by postnatal day; which improve prediction; develop a Web-based estimator using readily available information predict or death.We assessed 23-30 weeks' gestation born 17 centers Eunice Kennedy Shriver National...
Invasive candidiasis is a leading cause of infection-related morbidity and mortality in extremely low birth weight (<1000-g) infants. We quantified risk factors that predict infection premature infants at high compared clinical judgment with prediction model invasive candidiasis. The study involved prospective observational cohort infants≤1000 g 19 centers the Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network. At each sepsis evaluation,...
Current guidelines, initially published in 1995, recommend antenatal corticosteroids for mothers with preterm labor from 24 to 34 weeks' gestational age, but not before weeks due lack of data. However, many infants born gestation are provided intensive care.To determine if use is associated improvement major outcomes at 22 and 23 gestation.Cohort study data collected prospectively on inborn a birth weight between 401 g 1000 (N = 10,541) 25 January 1, 1993, December 31, 2009, academic...
<h3>Importance</h3> Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy 36 weeks' later gestation. To our knowledge, hypothermia trials have not been performed in presenting hours. <h3>Objective</h3> estimate the probability that to 24 risk of 18 months among encephalopathy. <h3>Design, Setting, and Participants</h3> A randomized clinical trial was conducted between April 2008 June 2016 gestation moderate severe...
Early-onset sepsis (EOS) remains a potentially fatal newborn condition. Ongoing surveillance is critical to optimize prevention and treatment strategies. To describe the current incidence, microbiology, morbidity, mortality of EOS among cohort term preterm infants. This prospective study included infants born at gestational age (GA) least 22 weeks birth weight greater than 400 g from 18 centers Eunice Kennedy Shriver National Institute Child Health Human Development Neonatal Research Network...
<h3>Importance</h3> Hypothermia at 33.5°C for 72 hours neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% 55%; longer cooling and deeper are neuroprotective in animal models. <h3>Objective</h3> To determine if duration (120 hours), (32.0°C), both superior neonates who full-term with moderate severe encephalopathy. <h3>Design, Setting, Participants</h3> A randomized, 2 × factorial design clinical trial performed 18 US centers the Eunice Kennedy Shriver National...
Chorioamnionitis is strongly linked to preterm birth and neonatal infection. The association between histological clinical chorioamnionitis cognitive, behavioral, neurodevelopmental outcomes among extremely neonates less clear. We evaluated the impact of on 18- 22-month in a contemporary cohort neonates. To compare 3 groups low-gestational-age infants with increasing exposure perinatal inflammation: no chorioamnionitis, alone, or plus chorioamnionitis. Longitudinal observational study at 16...
Extremely preterm infants are at risk for neurodevelopmental impairment (NDI). Early cranial ultrasound (CUS) is usual practice, but near-term brain MRI has been reported to better predict outcomes. We prospectively evaluated white matter abnormality (WMA) and cerebellar lesions, serial CUS adverse findings as predictors of outcomes 18 22 months' corrected age. late CUS, were read by masked central readers, in a large cohort (n = 480) <28 weeks' gestation surviving near term the Neonatal...
Hypothermia for 72 hours at 33.5°C neonatal hypoxic-ischemic encephalopathy reduces death or disability, but rates continue to be high. To determine if cooling 120 a temperature of 32.0°C disability age 18 months in infants with encephalopathy. Randomized 2 × factorial clinical trial neonates (≥36 weeks' gestation) US centers the Eunice Kennedy Shriver National Institute Child Health and Human Development Neonatal Research Network between October 2010 January 2016. A total 364 were randomly...
OBJECTIVES:Evaluate the spectrum of neurodevelopmental outcome in a contemporary cohort extremely preterm infants. We hypothesize that rate severe impairment (NDI) decreases over time.
Limited data suggest that higher hemoglobin thresholds for red-cell transfusions may reduce the risk of cognitive delay among extremely-low-birth-weight infants with anemia. We performed an open, multicenter trial in which a birth weight 1000 g or less and gestational age between 22 weeks 0 days 28 6 were randomly assigned within 48 hours after delivery to receive at lower until 36 postmenstrual discharge, whichever occurred first. The primary outcome was composite death neurodevelopmental...
Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development. Whether hydrocortisone treatment the second postnatal week can improve survival without bronchopulmonary and adverse neurodevelopmental effects unknown. We conducted trial involving infants who had gestational age of less than 30 weeks been intubated for at least 7 days 14 28 days. Infants were randomly assigned receive either (4 mg...