A5029057757- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Clinical Nutrition and Gastroenterology
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Development and Preterm Care
- Birth, Development, and Health
- Breastfeeding Practices and Influences
- Immune Response and Inflammation
- Fatty Acid Research and Health
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Child Nutrition and Water Access
- Pregnancy and preeclampsia studies
- Viral gastroenteritis research and epidemiology
- Infant Health and Development
- Nitric Oxide and Endothelin Effects
- Neonatal Health and Biochemistry
- Intestinal Malrotation and Obstruction Disorders
- Child Nutrition and Feeding Issues
- Neonatal and Maternal Infections
- Respiratory Support and Mechanisms
- Hemoglobinopathies and Related Disorders
- Thermal Regulation in Medicine
- Inflammatory mediators and NSAID effects
- Iron Metabolism and Disorders
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2021-2025
Research Network (United States)
2021-2025
Jacobi Medical Center
2025
Albert Einstein College of Medicine
2025
NorthShore University HealthSystem
2015-2024
University of Mannheim
2024
Heidelberg University
2024
University of Chicago
2013-2023
Columbia University Irving Medical Center
2023
Evanston Hospital
1997-2018
Abstract Bacteria are thought to contribute the pathogenesis of necrotizing enterocolitis (NEC), but it is unknown whether their interaction with epithelium can participate in initiation mucosal injury or they act only following translocation across a damaged intestinal barrier. Our aims were determine bacteria and epithelial TLR4 play roles well-established neonatal rat model novel murine NEC. Neonatal rats, C57BL/6J, C3HeB/FeJ (TLR4 wild type), C3H/HeJ mutant) mice delivered by Cesarean...
Necrotizing enterocolitis (NEC) is a common gastrointestinal disorder affecting premature infants. To investigate critically the importance of purported risk factors NEC (formula feeding, asphyxia, bacteria, and prematurity), we developed neonatal rat model that closely mimics human disease. Full-term newborn rats were stressed with formula and/or exogenous bacterial colonization subsequently evaluated grossly histologically for development intestinal injury. We found most animals treated...
We investigated the contributions of commensal bacteria to brain structural maturation by magnetic resonance imaging and behavioral tests in four 12 weeks old C57BL/6J specific pathogen free (SPF) germ (GF) mice. SPF mice had increased volumes fractional anisotropy major gray white matter areas higher levels myelination total brain, grey structures at either or age, demonstrating better organization. In open field test, mobility were less anxious than GF weeks. Morris water maze,...
Premature infants lack a normal intestinal microbial community and also at risk of perinatal hypoxic-ischemic (HI) brain injury, which is considered to be one the major factors for motor, sensory, cognitive deficits.We hypothesized that neonatal gut microbiota composition modulated immune reaction severity H-I injury.Neonatal C57BL/6J mouse pups were exposed protocol consisting permanent left carotid artery ligation, followed by 8% hypoxia 60 min.Microbial manipulation groups included 1)...
In prospective studies, tumor necrosis factor (TNF alpha) was detected in cerebrospinal fluid (CSF) of 33 38 children with bacterial meningitis (BM) but none 15 viral meningitis/encephalitis (P less than .001). BM CSF TNF alpha (less 35 to greater 25,500 pg/ml) correlated density .01), protein .001), endotoxin (LPS) gram-negative disease and consecutive febrile hospital days .001); initial 1000 pg/ml associated seizures .05). Only 5 (13%) had detectable plasma activity on admission. A higher...
Extremely premature (birth weight < 1250 g) infants are at high risk for acquiring late-onset sepsis and necrotizing enterocolitis, which associated with significant mortality morbidity. Own mother's milk contains protective (immune trophic) biofactors provide antimicrobial, anti-inflammatory, antioxidant, immunomodulatory functions, enhance intestinal microbiota, promote maturation. Many of these most highly concentrated in the expressed by mothers extremely infants. However, since do not...