A5075874197- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Food composition and properties
- Cell Adhesion Molecules Research
- Enzyme Production and Characterization
- Microbial Metabolites in Food Biotechnology
- Probiotics and Fermented Foods
- Proteins in Food Systems
- Infant Nutrition and Health
- Fatty Acid Research and Health
- Food Allergy and Anaphylaxis Research
- Trace Elements in Health
- Protein Hydrolysis and Bioactive Peptides
- Phytase and its Applications
- Polysaccharides Composition and Applications
- Heavy Metal Exposure and Toxicity
- Asthma and respiratory diseases
- Drug Transport and Resistance Mechanisms
- Allergic Rhinitis and Sensitization
- Ginseng Biological Effects and Applications
- Nutrition, Health and Food Behavior
- Pharmacological Effects of Natural Compounds
- Cholesterol and Lipid Metabolism
- Enzyme Catalysis and Immobilization
Changchun University
2012-2024
Liaocheng People's Hospital
2022-2024
Government of Jilin Province
2018-2024
Shanghai Children's Hospital
2024
Shanghai Jiao Tong University
2024
Changchun Institute of Technology
2024
Jiangnan University
2010-2023
Wuxi Fourth People's Hospital
2023
Jilin Agricultural University
2018-2023
Harbin University of Commerce
2023
Melittin, a naturally occurring antimicrobial peptide, demonstrates broad-spectrum activity, effectively suppressing and eliminating both Gram-positive Gram-negative bacteria, including specific drug-resistant strains. In this study, molecular simulation software was employed to investigate modify the structure of melittin with aim synthesizing modified peptide exhibiting enhanced antibacterial potency assessing its bacteriostatic properties. The primary research objectives were as follows:...
Intake of n-3 polyunsaturated fatty acids (PUFA) is helpful for cardiometabolic health. It improves lipid metabolism, and increasing PUFA often considered beneficial. However, the role n-6/n-3 in regulation metabolism has been much debated. Therefore, this study was performed on effect different proportions diet quality life patients with hyperlipidemia, aiming to explore appropriate provide theoretical basis development application nutritional blended oil future.These 75 participants were...
Transmembrane-4-L-six-family-1 (TM4SF1) was originally described as a cancer cell protein. Here, we show that it is highly expressed in the vascular endothelium of human cancers and banded pattern filopodia cultured endothelial cells (EC). TM4SF1 knockdown prevented formation, inhibited mobility, blocked cytokinesis, rendered EC senescent. Integrin-alpha5 integrin-beta1 subunits gave similar staining interacted constitutively with TM4SF1, whereas integrin often associated angiogenesis...
A GtfB enzyme 4,6-α-glucanotransferase from Streptococcus thermophilus lacking 761 N-terminal amino acids was heterologously expressed in Escherichia coli. Purified S. showed transglycosylation activities toward starch, resulting branch points of (α1→6)-glycosidic linkages plus linear chains (α1→4)-glycosidic linkages. After wheat starch modified at a rate 0.1 g/mL by 1-4 U/g pH 6.0 and 40 °C for 1 h, the weight-averaged molecular weight decreased 1.70 × 107 g/mol to 1.21 106 3.41 g/mol,...
To evaluate the effect of young apple polyphenols (YAP) on starch digestion and gut microbiota, complexes native wheat (NWS) with YAP, their main components chlorogenic acid (CA) phlorizin (P) were fabricated gelatinized.
To convert ginsenosides Rb1, Rb2, Rb3, and Rc into Rd by a single enzyme, putative β-glycosidase (Pxbgl) from the xylan-degrading bacterium Petroclostridium xylanilyticum was identified used. The kcat/Km value of Pxbgl for Rb3 18.18 ± 0.07 mM–1/s, which significantly higher than those other ginsenosides. converted almost all to with productivity 5884 μM/h, 346-fold that only β-xylosidase Thermoascus aurantiacus. Panax ginseng root notoginseng leaf 146 995 respectively. Mutants N293 K I447L...
The activation of LFA-1 (lymphocyte function-associated antigen) is a critical event for T cell co-stimulation. mechanism involves both affinity and avidity regulation, but the role each in remains unclear. We have identified antibodies that recognize block different states mouse I-domain. Monoclonal antibody 2D7 preferentially binds to low conformation, this specific binding abolished when locked high conformation. In contrast, M17/4 can bind forms LFA-1. Although are blocking antibodies,...
Salmonella is important as both a cause of clinical disease in swine and source food-borne transmission to humans. Lactobacillus Bacillus are often used antibiotic substitutes prevent infection. In this study, we evaluated the effects select mixture johnsonii L531, licheniformis BL1721 subtilis BS1715 (LBB-mix) prevention Salmonellaenterica serovar Infantis infection pig model. LBB-mix was orally administered newly weaned piglets for seven days before S. challenge. pretreatment ameliorated...
Resistant starch type 5 (RS5), a starch-lipid complex, exhibited potential health benefits in blood glucose and insulin control due to the low digestibility. The effects of crystalline structure chain length fatty acid on structure, vitro digestibility, fermentation ability RS5 were investigated by compounding (maize, rice, wheat, potato, cassava, lotus, ginkgo) different debranched starches with 12-18C (lauric, myristic, palmitic, stearic acids), respectively. complex showed V-type formed...