A5100640264- Gut microbiota and health
- Probiotics and Fermented Foods
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Chemical synthesis and alkaloids
- Analytical Chemistry and Chromatography
- Lung Cancer Treatments and Mutations
- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Clostridium difficile and Clostridium perfringens research
- Cancer Genomics and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Gastrointestinal motility and disorders
- Medicinal Plants and Bioactive Compounds
- Inflammatory Bowel Disease
- Digestive system and related health
- Chromatography in Natural Products
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Plant and Biological Electrophysiology Studies
- Mass Spectrometry Techniques and Applications
Chinese Academy of Agricultural Sciences
2017-2025
Institute of Quality Standards and Testing Technology for Agro Products
2025
Guiyang Medical University
2023-2025
Chinese Academy of Sciences
2013-2024
Beijing University of Agriculture
2022-2024
Chengdu Institute of Biology
2013-2024
Hangzhou Cancer Hospital
2016-2024
Heilongjiang International University
2024
Zhejiang University
2021-2024
Northwest A&F University
2020-2024
Dysbiosis in the intestinal microbiota of persons with inflammatory bowel disease (IBD) has been described, but there are still varied reports on changes abundance Bifidobacterium and Lactobacillus organisms patients IBD. The aim this investigation was to compare compositions mucosa-associated fecal bacteria IBD healthy controls (HCs). Fecal biopsy samples from 21 HCs, 15 Crohn's (CD) patients, 34 29 ulcerative colitis (UC) respectively, were analyzed by quantitative real-time PCR targeting...
The physiological role of microRNAs (miRNAs) in osteoblast differentiation remains elusive. Exosomal miRNAs isolated from human bone marrow-derived mesenchymal stem cells (BMSCs) culture were profiled using miRNA arrays containing probes for 894 matured miRNAs. Seventy-nine (∼8.84%) could be detected exosomes BMSC supernatants when normalized to endogenous control genes RNU44. Among them, nine exosomal up regulated and 4 under significantly (Relative fold>2, p<0.05) compared with the values...
The intestinal microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD), and geographical genetic backgrounds impact composition microbiota. However, there is a lack evidence regarding overall changes characteristics fecal-associated (FAM) mucosa-associated (MAM) Chinese patients with IBD. We recruited 26 Crohn's (CD), 46 ulcerative colitis (UC), 21 healthy individuals; we collected matched fresh fecal mucosal samples from same subjects. microbial...
Muscarinic acetylcholine receptors (M(1)-M(5)) regulate many key functions of the central and peripheral nervous system. Primarily because lack receptor subtype-selective ligands, precise physiological roles individual muscarinic subtypes remain to be elucidated. Interestingly, M(4) subtype is expressed abundantly in striatum various other forebrain regions. To study its potential role regulation locomotor activity functions, we used gene-targeting technology create mice that functional...
Abstract Objective Matrix metalloproteinases (MMPs) have long been considered excellent targets for osteoarthritis (OA) treatment. However, clinical utility of broad‐spectrum MMP inhibitors developed this purpose has restricted by dose‐limiting musculoskeletal side effects observed in humans. This study was undertaken to identify a new class potent and selective MMP‐13 that would provide histologic efficacy without toxicity. Methods Selectivity assays were using catalytic domains human MMPs....
Gut microbes play significant roles in colitis development. The current study was aimed to uncover the preventive effects of lycopene (LYC), a functional carotenoid component, on and accompanied behavior disorders. demonstrated that LYC treatment (50 mg/kg body weight/day) for 40 days prevented dextran sulfate sodium (DSS)-induced gut barrier damages inflammatory responses male mice. improved DSS-induced depression anxiety-like behavioral disorders by suppressing neuroinflammation synaptic...
Lycoris aurea (L' Hér.) Herb, a perennial grass species, produces unique variety of pharmacologically active Amaryllidaceae alkaloids. However, the key enzymes and their expression pattern involved in biosynthesis alkaloids (especially for galanthamine) are far from being fully understood. Quantitative real-time polymerase chain reaction (qRT-PCR), commonly used method quantifying gene expression, requires stable reference genes to normalize its data. In this study, choose appropriate under...
Sesamol, a liposoluble lignan extract, has already been proved to possess potent anti-inflammatory properties, and it could also regulate gut dysfunction. The purpose of the present research is explore protective effect sesamol on colitis mice. In current research, treatment (100 mg/kg bodyweight/day) for 6 weeks inhibited dextran sulphate sodium (DSS)-induced bodyweight loss Transmission electron microscopy hematoxylin eosin staining results showed that DSS-induced histopathological changes...
Heat stress (HS) can be detrimental to the gut health of swine. Many negative outcomes induced by HS are increasingly recognized as including modulation intestinal microbiota. In turn, microbiota is a unique ecosystem playing critical role in mediating host response. Therefore, we aimed characterize pigs' exposure short-term HS, explore possible link between and HS-related changes, serum cytokines, oxidation status, epithelial barrier function. Our findings showed that led morphological...
Post-weaning diarrhea in piglets reduces growth performance and increases mortality, thereby causing serious economic losses. The intestinal epithelial cells microbiota reciprocally regulate each other order to maintain homeostasis control inflammation. However, a relative paucity of research has been focused on the host-derived regulatory network that controls mucin O-glycans changes gut during infancy. At development stage just after birth, ontogeny epithelium, immune system, appear...
Gut microbiota is associated with hyperuricemia progression and can be regulated by Lactobacillus plantarum. However, the role of plantarum in still unknown. Thus, we constructed mouse model using potassium oxonate hypoxanthine treatment to explore effects LLY-606 supplementation on development hyperuricemia. The results showed that significantly reduced level serum uric acid through inhibiting secretion regulating transport. We also found inhibited inflammatory response activation...
Leucine restriction (LR) improves insulin resistance and promotes white adipose tissue browning. However, the effect of LR on obesity-associated cognitive impairment remains unclear. The present study found that an 8-week dramatically improved high-fat diet (HFD)-induced decline by preventing synaptic dysfunction, increasing expressions neurotrophic factors, inhibiting neuroinflammation in memory-related brain regions. Moreover, notably reshaped structure gut microbiota, which was manifested...
The gut microbiota is central to health and disorders such as inflammatory bowel disease. Differences in related geography ethnicity may hold the key recent changes incidence of microbiota-related disorders. Gut mucosal was analyzed 190 samples from 87 Caucasian Chinese subjects, Australia Hong Kong, comprising 22 patients with Crohn's disease, 30 ulcerative colitis, 29 healthy controls, 6 relatives Bacterial 16S rRNA microarray 454 pyrosequencing were performed. diverse health, regardless...
A major challenge in osteosarcoma (OS) is the selection of most effective chemotherapeutic agents for individual patients, while administration ineffective chemotherapy increases mortality and decreases quality life patients. This emphasizes need to evaluate every patient's probability responding each agent. We developed a profiling strategy serum exosomal microRNAs mRNAs OS patients with differential responses. Twelve miRNAs were up regulated 18 under significantly patient poor response...
// Ji-Feng Xu 1, * , Xiao-Hong Pan 2, Shui-Jun Zhang 1 Chen Zhao Bin-Song Qiu Hai-Feng Gu Jian-Fei Hong Li Cao Yu Bing Xia Qin Bi Ya-Ping Wang 2 Department of Orthopedics and Joint Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310014, PR China Cardiology, Second Affiliated College Medicine, University, 310009, These authors have contributed equally to this work Correspondence to: Xu, e-mail: xu_jifeng@hotmail.com Wang, wangypzju@163.com Keywords: osteosarcoma, CD47,...
Lycoris aurea, a medicinal species of the Amaryllidaceae family, is used in practice traditional Chinese medicine because its broad pharmacological activities alkaloids. Despite officinal and economic importance species, secondary mechanism for this relatively deficient. In study, we attempted to characterize transcriptome profiling L. aurea seedlings with methyl jasmonate (MeJA) treatment uncover molecular mechanisms regulating plant metabolite pathway. By using short reads sequencing...
Salmonella enterica serovar Infantis (S. Infantis) is a common source of foodborne gastroenteritis worldwide. Here, Lactobacillus rhamnosus GG (LGG) was administrated to weaned piglets for 1 week before S. challenge. caused decreased ileal mucosal microbiota diversity, dramatic amylovorus bloom, and abundance Arsenicicoccus, Janibacter, Kocuria, Nocardioides, Devosia, Paracoccus, Psychrobacter, Weissella. The beneficial effect LGG correlated with the moderate expansion L. amylovorus, agilis,...
The aim of the present study was to gain insight into molecular mechanism gefitinib resistance in non-small cell lung cancer (NSCLC), and demonstrate whether long noncoding RNA (lncRNA) expression signatures differ between gefitinib-sensitive PC9 gefitinib-resistant (PC9-R) lines. PC9-R cells were treated with and, after 48 h, proliferation apoptosis analyzed using a Cell Counting Kit-8 (CCK-8) assay flow cytometry. Microarray profiling lncRNAs undertaken both cells, profiles verified by...
An investigation of the fruiting bodies edible mushroom Ganoderma lucidum produced 13 steroids, containing one new lanostane-type triterpene compound, named ganoderterpene A (1). Nuclear magnetic resonance and high-resolution electrospray ionization mass spectrometry data were used to deduce these structures. All isolates evaluated for their ability suppress NO generation in BV-2 microglial cells treated with lipopolysaccharide (LPS) exhibited moderate strong inhibition effects, IC50 values...