A5100424816- Animal Nutrition and Physiology
- RNA modifications and cancer
- Gut microbiota and health
- MicroRNA in disease regulation
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
- Animal Behavior and Welfare Studies
- Cardiomyopathy and Myosin Studies
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Advanced biosensing and bioanalysis techniques
- Cellular Mechanics and Interactions
- Inflammatory Bowel Disease
- Food Quality and Safety Studies
- Oral microbiology and periodontitis research
- Immune Response and Inflammation
- Pasture and Agricultural Systems
- NF-κB Signaling Pathways
- Anesthesia and Neurotoxicity Research
- Enzyme function and inhibition
- Turfgrass Adaptation and Management
- Cavitation Phenomena in Pumps
- Signaling Pathways in Disease
- Ion Channels and Receptors
Minzu University of China
2024-2025
Zhongnan Hospital of Wuhan University
2013-2025
Wuhan University
2013-2025
State Ethnic Affairs Commission
2025
Wenzhou Medical University
2025
Shaanxi University of Chinese Medicine
2020-2024
Huazhong Agricultural University
2022-2024
Sichuan Agricultural University
2022-2024
Tsinghua University
2024
Marine Design & Research Institute of China
2024
The intestinal microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD), and geographical genetic backgrounds impact composition microbiota. However, there is a lack evidence regarding overall changes characteristics fecal-associated (FAM) mucosa-associated (MAM) Chinese patients with IBD. We recruited 26 Crohn's (CD), 46 ulcerative colitis (UC), 21 healthy individuals; we collected matched fresh fecal mucosal samples from same subjects. microbial...
Gastric cancer (GC) ranks the fifth most common cancer, and chemotherapy is one of treatments for GC. However, chemoresistance limits effectiveness leads to treatment failure. This study aims investigate biological effect miR-567 on gastric tumourigenesis reveal possible mechanism. We measured expression in 37 paired normal stomach tumour specimens, as well GC cell lines by Real-time PCR. The functional effects were validated using vitro vivo assays. Dual-luciferase report assays Chromatin...
Abstract The rapid rise of antibiotic resistance and slow discovery new antibiotics have threatened global health. While novel phage lysins emerged as potential antibacterial agents, experimental screening methods for pose significant challenges due to the enormous workload. Here, first unified software package, namely DeepLysin, is developed employ artificial intelligence mining vast genome reservoirs (“dark matter”) lysins. Putative are computationally screened from uncharacterized...
LIM kinase 1 (LIMK1) is a key regulator of the cytoskeletal organisation involved in cell proliferation and migration. Even though LIMK1 frequently dysregulated epithelial cancers, role mechanisms colorectal cancer (CRC) remains unclear. Immunohistochemical analysis was performed to examine expression clinical significance CRC samples. Loss- gain-of-function assay investigate effects aberrant on cellular biological behaviour cells vitro vivo. Immunoblotting immunoprecipitation used screen...
Abnormal activation of calcium channels has been shown to play crucial roles in tumor occurrence and development. However, the role inhibitors targeting progression immune regulation remains unclear, their clinical applications are still limited. We show that nifedipine (NIFE), a channel blocker, inhibits influx impair nuclear factor activated T cell 2 (NFAT2) dephosphorylation, activation, translocation, thus preventing transcriptional downstream signaling molecules suppress colorectal...
This study explored the impact of integrating fermented feed into starter diet lambs, focusing on growth, health, serum antioxidants, immune markers, rumen fermentation, and microbial communities. Thirty-six ten-day-old female Tail Han lambs were randomly divided three experimental groups, which separately fed with alfalfa hay (LA group), tail vegetable (LB supplemented 0.1% inoculants (LC group) during period. assessed influence various parameters, including growth performance, fiber...
Overexpression of LIM and SH3 protein 1 (LASP1) is required for colorectal cancer (CRC) development progression. Here, C‐Jun activation domain‐binding protein‐1 (Jab1), also known as COP9 signalosome subunit 5 (COPS5), was verified a new LASP1‐interacting through yeast two‐hybrid assay. The role COPS5 in LASP1‐mediated CRC progression remains unknown. GST pull‐down assay indicated that the domain LASP1 could directly bind to MPN COPS5. In vitro gain‐ loss‐of‐function analyses revealed...
Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) aberrantly overexpressed clinical CRC tissues undergoing chemotherapy. We studied if PTK6 contributed to chemoresistance human and mice.We obtained tissue samples from measured expression by immunohistochemistry. Gain- loss-of-function assays were performed study biological functions PTK6. constructed FLAG-tagged wild type (WT), kinase-dead,...
Candida utilis (CUM) possesses various biological effects, including anti-inflammatory, intestinal microbiota regulatory, and immunomodulatory activities. However, there has been little exploration regarding the effects of CUM on ulcerative colitis (UC). Therefore, this study aimed to investigate beneficial alleviating dextran sulfate sodium (DSS)-induced UC in mice explore potential underlying mechanisms. Here, effect was analyzed using a DSS-induced mouse model (n = 9), results which...
This study analyzes the global burden of breast cancer (BC) over past 30 years, identifies key risk factors, and projects future incidence mortality through 2050. Data were sourced from 2021 Global Burden Disease (GBD) database. The estimated annual percentage change (EAPC) was used to assess trends, country development measured using Socio-Demographic Index (SDI). Projections conducted Bayesian age-period-cohort autoregressive integrated moving average models. In 2021, approximately 2.12...
The pathogenesis of ulcerative colitis (UC) involves genetic, immunological, and environmental factors as well gut microbiota dysbiosis. As a natural antioxidant with various pharmacological activities widely present in Oleaceae plants, oleuropein (OLE) exhibits anti-inflammatory, anti-tumor, antiviral, hypoglycemic, cardioprotective effects. It has been validated that OLE extracted from olive oil can ameliorate UC. However, it remains unclear if how modulates the alleviation Therefore, this...
The utilization of surface plasmon resonance (SPR) sensors for real-time label-free molecular interaction analysis is already being employed in the fields vitro diagnostics and biomedicine. However, widespread application SPR technology hindered by its limited detection throughput high cost. To address this issue, study introduces a novel multifunctional MetaSPR high-throughput microplate biosensor featuring 3D nanocups array structure, aiming to achieve screening with reduced cost enhanced...
Abstract Accurate affinity assessments play an important role in drug discovery, screening, and efficacy evaluation. Label‐free biosensors are recognized as a dependable standard technology for addressing this challenge. This study constructs free electron density gradient‐enhanced meta‐surface plasmon resonance (FED‐MSPR) biosensor through finite‐difference time‐domain simulation model, the demonstrates superior detection performance accurately determining kinetic rate constants. By...
Pancreatic cancer (PC), as the leading cause of death worldwide, is one deadliest tumors with a very low 5-year survival rate. Therefore, it urgent to seek new biomarkers PC for more accurate and reliable treatments. To identify differentially expressed miRNAs (DEM) in tissues, we performed systematic microarray qRT-PCR analyses. We found miR-196b was top dysregulated DEM tissues compared corresponding adjacent positively correlated poor differentiation, tumor size, lymphatic invasion TNM...
Carbonic anhydrase (CA)-based biological CO2 capture is emerging as a prominent carbon and storage (CCS) technology. We developed tagged CA–Ferritin chimera, resulting in high-purity, high-activity, micrometer-sized CA aggregate, SazF, with yield of 576.6 mg/L (protein/medium). SazF has an optimum temperature 50 °C demonstrates thermal stability between 40 60 °C. It operates efficiently Tris–HCl buffer (pH = 8–9), making it compatible ship exhaust conditions. For enhanced reusability, was...
Abstract Background Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake milk production, which can lead to higher mortality rates newborn piglets. The probiotic Lactobacillus rhamnosus GG (LGG) is known improve resistance. However, whether supplementing LGG sensitivity sows enhance lactation performance, particularly the early survival of offspring remains unclear. Hence, we explored effects mechanisms during on sow sensitivity, survival. In...
An enantiomeric pair of rare cyperane-type sesquiterpenoids, (+)- and (−)-gracilistones C (1a, 1b), together with a novel norsesquiterpenoid, gracilistone D (2), bearing bicyclic lactone system were isolated from the root bark Acanthopanax gracilistylus using LC-MS-IT-TOF analyses. The structures absolute configurations 1a, 1b, 2 elucidated by 1D 2D NMR spectroscopy, X-ray diffraction, ECD spectroscopic methods. Intermediate 1b suggests possible biosynthesis process involving compound 2....
To research the effect of volute geometry on radial force characteristics centrifugal pump during starting process, choosing a with head 87m as object. The pumping chamber is redesigned into single-volute and double-volute similar external characteristics, circulation pipeline system established. RNG k-ε turbulence model employed to calculate unsteady process two kinds pumps. variation trends received by impeller start-up are obtained. internal flow field evolution pumps compared analyzed....