A5048478782- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Sleep and related disorders
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Statistical Methods and Inference
- Maternal Mental Health During Pregnancy and Postpartum
- Meta-analysis and systematic reviews
- Optimal Experimental Design Methods
- Neonatal Respiratory Health Research
- Advanced Statistical Methods and Models
- Infant Development and Preterm Care
- Chronic Disease Management Strategies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Restless Legs Syndrome Research
- Cancer therapeutics and mechanisms
- Obstructive Sleep Apnea Research
- Scientific Computing and Data Management
- Adolescent and Pediatric Healthcare
- Treatment of Major Depression
- Advanced Causal Inference Techniques
- Reproductive Health and Technologies
- Cancer Treatment and Pharmacology
- Therapeutic Uses of Natural Elements
- Fibromyalgia and Chronic Fatigue Syndrome Research
RTI International
2021-2024
Research Network (United States)
2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
University of North Carolina at Chapel Hill
2016-2020
Importance Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are adverse neurologic outcomes low-risk infants. Whether this association exists contemporary practice is uncertain because most randomized clinical trials administered earlier and higher doses than currently recommended. Objective To evaluate whether the pretreatment death or grade 2 3 BPD 36 weeks’...
Anthracyclines are a class of antitumor compounds that successful and widely used but suffer from cardiotoxicity acquired tumor resistance. Formaldehyde interacts with anthracyclines to enhance efficacy, bypass resistance mechanisms, improve the therapeutic profile, change mechanism action topoisomerase II poison DNA cross-linker. Contrary current dogma, we show both efficient cross-linking potent synergy in combination formaldehyde correlate anthracycline's ability form cyclic conjugates as...
Introduction: Urolithiasis causes a significant impact on health-related quality of life (HRQOL). Patients with kidney stones have high levels stress and anxiety. Symptom resolution often requires treatment. Travel distance is barrier to care but little known about its effects HRQOL. We hypothesize that increased treatment site associated decreased HRQOL.
 Methods: history were enrolled at 11 tertiary centers as part the QOL Stone Consortium North America. HRQOL data obtained using...
The sequential parallel comparison design (SPCD), with sequence groups P:P, P:T, and T:T, together the exclusion of second-period information from placebo responders in first period, can serve usefully for studies highly favorable response, example, psychiatric clinical trials. This paper presents a methodology first-period treatment difference overall population nonresponders as well other available sources that could be potential interest. Without any assumptions, hypothesis testing method...
Journal Article Accepted manuscript Insomnia in Pregnancy and Obstetric Outcomes Get access Rachel Friedlander, Friedlander Department of Obstetrics Gynecology, Northwestern University Feinberg School Medicine, Chicago IL, USA Corresponding: MD, 250 E. Superior Street, #5-2145, Chicago, IL 60611, [email protected] https://orcid.org/0000-0002-7143-8689 Search for other works by this author on: Oxford Academic Google Scholar Xiaoning Huang, Huang https://orcid.org/0000-0001-5813-5993 Phyllis...
Importance Short sleep duration during pregnancy and the perimenopausal period has been associated with adverse cardiometabolic outcomes. However, it remains unclear how changes after delivery whether such are health of birthing people. Objective To investigate persistently short is incident hypertension metabolic syndrome. Design, Setting, Participants This secondary analysis Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be Heart Health Study (NuMoM2b-HHS), an ongoing...
SUMMARY In monitoring clinical trials, the question of futility, or whether data thus far suggest that results at final analysis are unlikely to be statistically successful, is regularly interest over course a study. However, opposite viewpoint study sufficiently demonstrating proof concept (POC) and should continue valuable consideration ultimately addressed with high POC power so promising not prematurely terminated. Conditional often used assess this article interconnects ideas assessing...
Introduction: Racial disparities in risk of adverse pregnancy outcomes (APOs) and cardiovascular health (CVH) after delivery are well-established. Therefore, we sought to quantify the extent which APOs explained racial differences CVH. Methods: We included non-Hispanic (NH) Black NH White individuals from prospective, longitudinal nuMoM2b-HHS cohort. Race ethnicity, represent social constructs, were self-reported. (hypertensive disorders [HDP], small for gestational age [SGA], preterm birth...