A5024524978- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Genetic Associations and Epidemiology
- Cardiovascular Health and Disease Prevention
- Hepatitis C virus research
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Genomic variations and chromosomal abnormalities
- Hepatitis B Virus Studies
- Lipid metabolism and disorders
- Genetics and Neurodevelopmental Disorders
- Cerebrovascular and Carotid Artery Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Angiogenesis and VEGF in Cancer
- Genetic factors in colorectal cancer
- Genetic Mapping and Diversity in Plants and Animals
- Colorectal Cancer Surgical Treatments
- Retinopathy of Prematurity Studies
- Lipoproteins and Cardiovascular Health
- Thyroid Disorders and Treatments
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
China Medical University Hospital
2016-2024
China Medical University
2016-2024
Kaohsiung Medical University
2009-2021
Kaohsiung Medical University Chung-Ho Memorial Hospital
2007-2016
Human Genome Sciences (United States)
2013
Medical Genetics Center
2011
Center for Environmental Health
2011
New York Genome Center
2002-2010
Columbia University
2001-2010
Clinical Research Management
2008
Genome-wide association studies have linked single nucleotide polymorphisms (SNPs) near the interleukin-28B gene to hepatitis C virus genotype 1 (HCV-1) response peginterferon/ribavirin treatment. We aimed explore impact on treatment outcomes of Asian HCV-2 patients. determined rs8105790, rs8099917, rs4803219, and rs10853728 be candidate SNPs in 482 patients treated with standard care. Because first three were very strong linkage disequilibrium one another (r2 = 0.94-0.96), rs8099917...
<b><i>Background/Aims:</i></b> MicroRNA miR-21, miR-221 and miR-145 have been implicated in the cardiovascular system. We aimed to compare serum levels of three microRNAs (miRNAs) different severities cerebrovascular diseases evaluate feasibility using these miRNAs as biomarkers for stroke. <b><i>Methods:</i></b> enrolled 167 subjects with ischemic stroke, 66 atherosclerosis any carotid plaque score 157 healthy controls. These types represent...
A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for cancer using mathematical models early somatic genetic deletions tumor tissues followed targeted linkage analysis. Comparative genomic hybridization was used study 61 tumors from 37 families with no identified mutations. Branching and phylogenetic tree predicted that loss 13q one earliest events hereditary cancers. In...
Lectin-like oxidized LDL receptor-1 (LOX-1) is a surface scavenger receptor for low-density lipoprotein (oxLDL). Several transcription factors have been reported to regulate LOX-1 expression. MicroRNAs are small noncoding RNAs that control gene expression, but there no reports of expression being regulated by microRNAs. Because the microRNA let-7g has predicted bind mRNA, we investigated whether can Our experiments first demonstrated oxLDL reduce We later confirmed binding site on...
Kawasaki disease (KD) is characterized by systemic vasculitis with unknown etiology. Previous studies from Japan indicated that a gene polymorphism of ITPKC (rs28493229) responsible for susceptibility to KD. We collected DNA samples 1,531 Taiwanese subjects (341 KD patients and 1,190 controls) genotyping ITPKC. In this study, no significant association was noted the between controls patients, although CC genotype overrepresented. further combined our data previously published case/control in...
Colorectal cancer (CRC) is associated with high recurrence and mortality. Because deregulation of microRNAs CRC development recurrence, the expression levels can be a simple reliable biomarker to detect postoperative early relapse, thereby helping physicians treat high-risk patients more efficiently. We used microRNA arrays observed that microRNA-93 had substantially different in (recurrence within 12 months after surgery) non-early relapse patients. The replication study, which included 35...
Amyloid beta-peptide (Aβ), the main component of senile plaques in Alzheimer's disease (AD) brains, is generated from sequential cleavage amyloid precursor protein (APP) by β- and γ-secretase. Hyperglycemia diabetes may compromise barrier integrity endothelial cells (ECs). However, roles APP response to high glucose (HG) remain be delineated. The aims this study were test whether HG increase Aβ secretion, thereby leading heightened paracellular permeability ECs.We determined effects on...
purpose. To investigate the impact of a positive family history high myopia on level and onset its ocular components. methods. A cross-sectional study was conducted. The participants (aged 17 to 45 years) were categorized into four groups: normal, mild, moderate, myopia. age first glasses for used as quantified. Parental effect corneal curvature (CC), anterior chamber depth (ACD), axial length (AXL) analyzed. results. included 185 normal subjects, 170 140 392 myopes. Family strongly...
Colorectal cancer (CRC) is one of the leading malignant cancers with a rapid increase in incidence and mortality. The recurrences CRC after curative resection are sometimes unavoidable often take place within first year surgery. MicroRNAs may serve as biomarkers to predict early recurrence CRC, but identifying them from over 1,400 known human microRNAs challenging costly. An alternative approach analyze existing expression data messenger RNAs (mRNAs) because generally speaking levels their...
Aim: The present study aimed to investigate the regulation and involvement of miR-221 in differentiation human adipose tissue-derived mesenchymal stem cells (hASCs). relationships between pro-inflammatory markers adipokines were also explored. Methods: Eight tissues obtained from four obese (mean body mass index (BMI) =31.7 kg/m2) lean BMI= 21.5 women. hASCs induced differentiate, related gene expression measured hASC-differentiated adipocytes using real-time reverse transcriptase polymerase...
5-Fluorouracil (5-FU)-based chemotherapy is widely used for the treatment of colorectal cancer (CRC). While optimal doses 5-FU are generally established based on a patient's estimated body surface area, plasma concentrations vary among patients. In addition, hyperglycemia in patients with CRC has been reported as risk factor poor prognosis. The aim present study was to investigate whether affects antiproliferative effect human colon cells (SW480, SW620, LoVo, and HCT116). Growth inhibition...