A5032045636- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Microfluidic and Bio-sensing Technologies
- Cancer-related Molecular Pathways
- Heart Rate Variability and Autonomic Control
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Cardiovascular Syncope and Autonomic Disorders
- Alzheimer's disease research and treatments
- Protease and Inhibitor Mechanisms
- Cardiovascular and Diving-Related Complications
- Neurosurgical Procedures and Complications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Retinal Imaging and Analysis
Kaohsiung Medical University
2015-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015-2024
Tungs' Taichung MetroHarbor Hospital
2010-2016
Chung Shan Medical University
2010-2016
National Yang Ming Chiao Tung University
2002-2016
Taipei Medical University
2014-2016
First Hospital of Jilin University
2016
Jilin University
2016
Taipei Veterans General Hospital
2002-2014
China Medical University
2010-2014
Background and Purpose— The safety efficacy of alteplase for ischemic stroke has not been examined in Chinese patients. We assessed the acute daily clinical practice Taiwan. Methods— A prospective, multicenter, observational study was conducted Taiwan from December 2004 to July 2008. Eligible patients (241) receiving were recruited divided into 2 groups: standard dose (0.90±0.02 mg/kg, n=125) lower (0.72±0.07 n=116). Primary outcome measures safety: symptomatic intracerebral hemorrhage death...
Amyloid beta-peptide (Aβ), the main component of senile plaques in Alzheimer's disease (AD) brains, is generated from sequential cleavage amyloid precursor protein (APP) by β- and γ-secretase. Hyperglycemia diabetes may compromise barrier integrity endothelial cells (ECs). However, roles APP response to high glucose (HG) remain be delineated. The aims this study were test whether HG increase Aβ secretion, thereby leading heightened paracellular permeability ECs.We determined effects on...
This study is the first to investigate anticancer effects of α-mangostin in human glioblastoma cells. α-Mangostin decreases cell viability by inducing autophagic death but not apoptosis. Pretreatment cells with autophagy inhibitors 3-methyladenine (3-MA) and bafilomycin or knockdown beclin-1, resulted suppression α-mangostin-mediated death. We also found that liver kinase B1 (LKB1)/AMP-activated protein (AMPK) signaling a critical mediator α-mangostin-induced inhibition growth. Activation...
The relationship between the dose of recombinant tissue-type plasminogen activator (r-tPA) and its safety/efficacy for ischemic stroke has not been well evaluated in East Asian population. We assessed different doses r-tPA acute Chinese patients.A total 1004 eligible patients were classified according to received managing stroke: 0.9 mg/kg (n=422), 0.8 (n=202), 0.7 (n=199), 0.6 (n=181). safety outcome was symptomatic intracerebral hemorrhage death within 3 months. efficacy good functional...
The mechanism of transient global amnesia (TGA) is not clear. Attempting to support the hypothesis that retrograde venous hypertension causing cerebral ischemia plays a role in pathogenesis TGA, authors used cranial three-dimensional time-of-flight (TOF) MR angiography (MRA) detect possible intracranial flow TGA patients.The frequency abnormal signals on TOF MRA was compared 10 patients with 50 age- and gender-matched normal individuals. In signals, other examinations (cerebral digital...
The triglyceride-glucose (TyG) index has recently been proposed as a reliable marker of insulin resistance. There is insufficient evidence to verify that the TyG correlated with functional outcomes and hemorrhagic transformation in patients stroke treated intravenous thrombolysis (IVT).We designed multicenter cohort study, which enrolled acute ischemic IVT between December 2004 2016. was divided into tertiles calculated on continuous scale. Unfavorable were defined by modified Rankin Scale...
Early diagnosis and treatment of central nervous system (CNS) tuberculosis (TB) are very important because its high morbidity mortality characteristics. However, the clinical symptoms, laboratory neuroimaging findings CNS TB nonspecific, no matter whether they common form, tuberculous meningitis (TBM), or rare intracranial tuberculomas. We report a case TBM with miliary pattern tuberculomas, although initial was masked by an atypical neuropsychiatric presentation, cerebrospinal fluid (CSF)...
Abnormal extracranial venous drainage modality has been considered an etiology of transient global amnesia (TGA). Evidence suggests that the transmission intrathoracic/intraabdominal pressure during a Valsalva maneuver (VM) is mainly through vertebral system, and patency internal jugular vein (IJV) essential for releasing. We hypothesize obstruction IJV contributing factor in TGA pathogenesis. A magnetic resonance (MR) imaging protocol was used 45 patients age- sex-matched controls to assess...
A vertebral artery (VA) terminating in a posterior inferior cerebellar (PICA) is often considered to be normal variation associated with VA hypoplasia. We aimed investigate the clinical significance of this cerebrovascular variant. total 80 patients clinically evident events circulation were examined by duplex sonography and magnetic resonance angiography (MRA). Eighty healthy subjects who had MRA check-up recruited as controls. PICA termination (PICA-VA) was identified not communicating...
Prolonged hospital stay and readmission are prevalent problems for stroke patients in Taiwan after the acute stage, partly due to unmet need of post-acute care. In March 2014, Taiwan's National Health Insurance Administration launched a nationwide Post-Acute Care-CerebroVascular Disease (PAC-CVD) program. The Stroke Society, coordinating 11 allied disciplines, took responsibility preparation implementation As June 2016, 6839 consecutive were enrolled. On discharge from PAC program,...
<i>Background:</i> The frequency of jugular venous reflux (JVR) is higher in patients with transient monocular blindness (TMB). We hypothesize that JVR influences ocular outflow, and resulting disturbances cerebral circulation might be a cause TMB. To substantiate this hypothesis, we aimed to demonstrate that: (1) TMB have vasculature changes their retinal venules, (2) could influence as revealed by dilated venules. <i>Methods:</i> This study has 2 parts. case-control...
<i>Background:</i> Previous limited observations have suggested that atherosclerosis may affect the distensibility of carotid sinus and then impair baroreflex sensitivity (BRS). No studies been done to compare BRS heart rate variability (HRV) in patients with stenosis normal controls. <i>Methods:</i> A convenience-consecutive sample 118 transient ischemic attack or minor stroke 3 months 1 year before (mean 6 months) who met study criteria were referred neurovascular...
Baroreflex sensitivity (BRS) and heart rate variability (HRV) are potential therapeutic targets. The present study was conducted to assess changes in BRS HRV after monotherapy with losartan versus that of atenolol uncomplicated essential hypertension. Thirty subjects hypertension were randomized receive 50 mg 100 (n = 15) or (N daily for 6 months. Instantaneous systolic blood pressure (SBP) assessed using servo-controlled infrared finger plethysmography before treatment at the end 3 months...
Although a lower level of non-high-density lipoprotein cholesterol (HDL-C) was reported to be inversely associated with spontaneous intracranial hemorrhage (ICH), no enough evidence has verified whether lipid profiles modify hemorrhagic transformation and functional outcomes in patients acute ischemic treated thrombolysis.This multicenter cohort study included 2373 stroke intravenous thrombolysis between December 2004 2016. Of these, 1845 were categorized into either the hyperlipidemia or...
Background: Previous neuroimaging and ultrasound studies suggested that compression stenosis of the internal jugular vein (IJV) in patients with transient global amnesia (TGA) may impair IJV drainage, while a patent releases intracranial pressure caused by Valsalva maneuver (VM). Methods: Seventy-nine TGA complete examination data during admission were recruited prospectively to evaluate which included time-averaged mean velocity, cross-sectional lumen area at vein's middle (J2) distal (J3)...
In previous studies of transverse sinus (TS) hypoplasia, discrepancies between TS diameter measured by magnetic resonance venography (MRV) and contrast T1-weighted (contrast T1) were observed. To investigate these discrepancies, considering that hypoplasia is associated with neurological disorders, we performed a post hoc analysis prospectively collected data from 3 case–control on transient global amnesia (TGA), monocular blindness (TMB), panic disorders while retaining the original...
Pneumonia is the leading cause of death in patients with Parkinson's disease (PD). However, few studies have been performed to explore risk factors for pneumonia development PD.We conducted a nationwide population-based cohort study PD identify these developing pneumonia. Participants newly diagnosed between 2000 and 2009 were enrolled from 2000-2010 National Health Insurance Research Database Taiwan. We compared an incidence hospitalization vs those without, Cox proportional hazard models...